PDB-code
Browse kinase entries (page 109 of 282)
First 105 106 107 PreviousLast113 112 111 Next| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | File |
|---|---|---|---|---|---|---|---|---|---|---|
 | EGFR | EGFR | TK | 7zyn | A | A | n-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | Human | Show |  |
| EGFR | EGFR | TK | 7zyn | A | B | n-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | Human | Show | |
| EGFR | EGFR | TK | 7zyp | A | propan-2-yl 2-[[4-(4-azanylpiperidin-1-yl)-2-methoxy-phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate | Human | Show | | |
| EGFR | EGFR | TK | 7zyq | A | A | phenyl 2-[[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxy-phenyl]amino]-4-(1h-indol-3-yl)pyrimidine-5-carboxylate | Human | Show | |
| EGFR | EGFR | TK | 7zyq | A | B | phenyl 2-[[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxy-phenyl]amino]-4-(1h-indol-3-yl)pyrimidine-5-carboxylate | Human | Show | |
| EGFR | EGFR | TK | 8a27 | A | A | (2r)-2-(6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxidanylidene-7-(trifluoromethyl)-1h-isoindol-2-yl]-n-(1,3-thiazol-2-yl)ethanamide | Human | Show | |
| EGFR | EGFR | TK | 8a27 | A | B | (2r)-2-(6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxidanylidene-7-(trifluoromethyl)-1h-isoindol-2-yl]-n-(1,3-thiazol-2-yl)ethanamide | Human | Show | |
| EGFR | EGFR | TK | 8a2a | A | A | (2r)-2-(6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxidanylidene-7-(trifluoromethyl)-1h-isoindol-2-yl]-n-(1,3-thiazol-2-yl)ethanamide | Human | Show | |
| EGFR | EGFR | TK | 8a2a | A | B | (2r)-2-(6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxidanylidene-7-(trifluoromethyl)-1h-isoindol-2-yl]-n-(1,3-thiazol-2-yl)ethanamide | Human | Show | |
| EGFR | EGFR | TK | 8a2b | A | A | (2r)-2-(6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxidanylidene-7-(trifluoromethyl)-1h-isoindol-2-yl]-n-(1,3-thiazol-2-yl)ethanamide | Human | Show | |
| EGFR | EGFR | TK | 8a2b | A | B | (2r)-2-(6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxidanylidene-7-(trifluoromethyl)-1h-isoindol-2-yl]-n-(1,3-thiazol-2-yl)ethanamide | Human | Show | |
| EGFR | EGFR | TK | 8a2d | A | A | (2r)-2-[4-[bis(fluoranyl)methyl]-6-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-7-methyl-indazol-2-yl]-2-spiro[6,7-dihydropyrrolo[1,2-c]imidazole-5,1'-cyclopropane]-1-yl-n-(1,3-thiazol-2-yl)ethanamide | Human | Show | |
| EGFR | EGFR | TK | 8a2d | A | B | (2r)-2-[4-[bis(fluoranyl)methyl]-6-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-7-methyl-indazol-2-yl]-2-spiro[6,7-dihydropyrrolo[1,2-c]imidazole-5,1'-cyclopropane]-1-yl-n-(1,3-thiazol-2-yl)ethanamide | Human | Show | |
| EGFR | EGFR | TK | 8d73 | A | A | (3s,4r)-3-fluoro-1-(4-{[4-(methylamino)-1-(propan-2-yl)pyrido[3,4-d]pyridazin-7-yl]amino}pyrimidin-2-yl)piperidin-4-ol | Human | Show | |
| EGFR | EGFR | TK | 8d73 | A | B | (3s,4r)-3-fluoro-1-(4-{[4-(methylamino)-1-(propan-2-yl)pyrido[3,4-d]pyridazin-7-yl]amino}pyrimidin-2-yl)piperidin-4-ol | Human | Show | |
| EGFR | EGFR | TK | 8d76 | A | A | (3s,4r)-3-fluoro-1-(4-{[8-{3-[(methanesulfonyl)methyl]azetidin-1-yl}-5-(propan-2-yl)-2,7-naphthyridin-3-yl]amino}pyrimidin-2-yl)-3-methylpiperidin-4-ol | Human | Show | |
| EGFR | EGFR | TK | 8d76 | A | B | (3s,4r)-3-fluoro-1-(4-{[8-{3-[(methanesulfonyl)methyl]azetidin-1-yl}-5-(propan-2-yl)-2,7-naphthyridin-3-yl]amino}pyrimidin-2-yl)-3-methylpiperidin-4-ol | Human | Show | |
| EGFR | EGFR | TK | 8dsw | A | phosphoaminophosphonic acid-adenylate ester | Human | Show | | |
| EGFR | EGFR | TK | 8eme | A | - | Human | Show | | |
| EGFR | EGFR | TK | 8eme | B | n-{7-methyl-1-[(3s)-1-(prop-2-enoyl)azepan-3-yl]-1h-benzimidazol-2-yl}-5-(prop-2-enamido)thiophene-3-carboxamide | Human | Show | | |
| EGFR | EGFR | TK | 8f1h | A | n-[(5p,8s,10r)-4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]prop-2-enamide | Human | Show | | |
| EGFR | EGFR | TK | 8f1w | A | 1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one | Human | Show | | |
| EGFR | EGFR | TK | 8f1x | A | A | propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate | Human | Show | |
| EGFR | EGFR | TK | 8f1x | A | B | propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate | Human | Show | |
| EGFR | EGFR | TK | 8f1y | A | 1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one | Human | Show | | |
| EGFR | EGFR | TK | 8f1z | A | (2p)-3-(3-chloro-2-methoxyanilino)-2-[3-(2-methoxy-2-methylpropoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one | Human | Show | | |
| EGFR | EGFR | TK | 8fv3 | A | A | phosphoaminophosphonic acid-adenylate ester | Human | Show | |
| EGFR | EGFR | TK | 8fv3 | A | B | phosphoaminophosphonic acid-adenylate ester | Human | Show | |
| EGFR | EGFR | TK | 8fv4 | A | A | phosphoaminophosphonic acid-adenylate ester | Human | Show | |
| EGFR | EGFR | TK | 8fv4 | A | B | phosphoaminophosphonic acid-adenylate ester | Human | Show | |
| EGFR | EGFR | TK | 8g63 | A | ralimetinib | Human | Show | | |
| EGFR | EGFR | TK | 8gb4 | A | A | 2-[(r)-(1h-benzimidazol-2-yl)(3-fluorophenyl)methyl]-6-[4-(1-methylpiperidin-4-yl)phenyl]-2,3-dihydro-1h-isoindol-1-one | Human | Show | |
| EGFR | EGFR | TK | 8gb4 | A | B | 2-[(r)-(1h-benzimidazol-2-yl)(3-fluorophenyl)methyl]-6-[4-(1-methylpiperidin-4-yl)phenyl]-2,3-dihydro-1h-isoindol-1-one | Human | Show | |
| EGFR | EGFR | TK | 8gk5 | A | ~{n}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide | Human | Show | | |
| EGFR | EGFR | TK | 8h7x | A | 5-chloro-n~4~-[2-(dimethylphosphoryl)phenyl]-n~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine | Human | Show | | |
| EGFR | EGFR | TK | 8hv1 | A | 3-(3-bromophenyl)-1,4-dihydro-1,2,4-triazole-5-thione | Human | Show | | |
| EGFR | EGFR | TK | 8hv2 | A | A | ~{n}-pyridin-2-ylprop-2-enamide | Human | Show | |
| EGFR | EGFR | TK | 8hv2 | A | B | ~{n}-pyridin-2-ylprop-2-enamide | Human | Show | |
| EGFR | EGFR | TK | 8hv3 | A | ~{n}-pyridin-2-ylprop-2-enamide | Human | Show | | |
| EGFR | EGFR | TK | 8hv4 | A | ~{n}-pyridin-2-ylprop-2-enamide | Human | Show | | |
| EGFR | EGFR | TK | 8hv5 | A | A | ~{n}-(1-methylbenzimidazol-4-yl)prop-2-enamide | Human | Show | |
| EGFR | EGFR | TK | 8hv5 | A | B | ~{n}-(1-methylbenzimidazol-4-yl)prop-2-enamide | Human | Show | |
| EGFR | EGFR | TK | 8hv6 | A | A | ~{n}-quinolin-7-ylprop-2-enamide | Human | Show | |
| EGFR | EGFR | TK | 8hv6 | A | B | ~{n}-quinolin-7-ylprop-2-enamide | Human | Show | |
| EGFR | EGFR | TK | 8hv7 | A | ~{n}-[7-(dimethylamino)-2-methyl-pyrazolo[1,5-a]pyrimidin-5-yl]prop-2-enamide | Human | Show | | |
| EGFR | EGFR | TK | 8hv8 | A | ~{n}-pyrazolo[1,5-a]pyridin-2-ylprop-2-enamide | Human | Show | | |
| EGFR | EGFR | TK | 8hv9 | A | A | ~{n}-(4-phenylpyridin-2-yl)prop-2-enamide | Human | Show | |
| EGFR | EGFR | TK | 8hv9 | A | B | ~{n}-(4-phenylpyridin-2-yl)prop-2-enamide | Human | Show | |
| EGFR | EGFR | TK | 8hva | A | ~{n}-[6-(1-methylindol-3-yl)pyrimidin-4-yl]prop-2-enamide | Human | Show | | |
| EGFR | EGFR | TK | 8hy7 | A | ~{n}-[3-[[6-fluoranyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]quinazolin-4-yl]amino]phenyl]prop-2-enamide | Human | Show | |
