PDB-code
Browse kinase entries (page 144 of 282)
First 140 141 142 PreviousLast148 147 146 Next| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | File |
|---|---|---|---|---|---|---|---|---|---|---|
 | IRAK4 | IRAK | TKL | 6rfi | A | A | methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate | Human | Show |  |
| IRAK4 | IRAK | TKL | 6rfi | A | B | methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate | Human | Show | |
| IRAK4 | IRAK | TKL | 6rfi | B | A | methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate | Human | Show | |
| IRAK4 | IRAK | TKL | 6rfi | B | B | methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate | Human | Show | |
| IRAK4 | IRAK | TKL | 6rfj | A | methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate | Human | Show | | |
| IRAK4 | IRAK | TKL | 6rfj | B | methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate | Human | Show | | |
| IRAK4 | IRAK | TKL | 6thw | A | 7-fluoranyl-4-(1-methylcyclopropyl)oxy-~{n}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | Show | | |
| IRAK4 | IRAK | TKL | 6thw | B | 7-fluoranyl-4-(1-methylcyclopropyl)oxy-~{n}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | Show | | |
| IRAK4 | IRAK | TKL | 6thx | A | 2-[4-[(1-methylcyclopropyl)amino]-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-6-yl]ethanenitrile | Human | Show | | |
| IRAK4 | IRAK | TKL | 6thx | B | 2-[4-[(1-methylcyclopropyl)amino]-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-6-yl]ethanenitrile | Human | Show | | |
| IRAK4 | IRAK | TKL | 6thz | A | 7-fluoranyl-~{n}-[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]-4-(1-methylcyclopropyl)oxy-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | Show | | |
| IRAK4 | IRAK | TKL | 6thz | B | 7-fluoranyl-~{n}-[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]-4-(1-methylcyclopropyl)oxy-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | Show | | |
| IRAK4 | IRAK | TKL | 6ti8 | A | A | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 6ti8 | A | B | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 6ti8 | B | A | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 6ti8 | B | B | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 6ti8 | C | A | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 6ti8 | C | B | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 6ti8 | D | A | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 6ti8 | D | B | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 6tia | A | 4-(1-methylcyclopropyl)oxy-~{n}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(1-methylpyrazol-4-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | Show | | |
| IRAK4 | IRAK | TKL | 6tia | B | 4-(1-methylcyclopropyl)oxy-~{n}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(1-methylpyrazol-4-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | Show | | |
| IRAK4 | IRAK | TKL | 6uya | A | A | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 6uya | A | B | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 6uya | B | A | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 6uya | B | B | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 6uya | C | A | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 6uya | C | B | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 6uya | D | A | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 6uya | D | B | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 6vql | A | 6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide | Human | Show | | |
| IRAK4 | IRAK | TKL | 6vql | B | 6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide | Human | Show | | |
| IRAK4 | IRAK | TKL | 6vql | C | 6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide | Human | Show | | |
| IRAK4 | IRAK | TKL | 6vql | D | 6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide | Human | Show | | |
| IRAK4 | IRAK | TKL | 7c2v | A | A | 2-(2-methylpyridin-4-yl)-n-[2-morpholin-4-yl-5-[(3r)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 7c2v | A | B | 2-(2-methylpyridin-4-yl)-n-[2-morpholin-4-yl-5-[(3r)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 7c2v | C | A | 2-(2-methylpyridin-4-yl)-n-[2-morpholin-4-yl-5-[(3r)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 7c2v | C | B | 2-(2-methylpyridin-4-yl)-n-[2-morpholin-4-yl-5-[(3r)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 7c2w | A | A | - | Human | Show | |
| IRAK4 | IRAK | TKL | 7c2w | B | A | - | Human | Show | |
| IRAK4 | IRAK | TKL | 7c2w | C | A | - | Human | Show | |
| IRAK4 | IRAK | TKL | 7c2w | D | A | - | Human | Show | |
| IRAK4 | IRAK | TKL | 7qg1 | A | methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]-5-oxidanylidene-pyrido[4,3-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate | Human | Show | | |
| IRAK4 | IRAK | TKL | 7qg2 | A | A | 6-methyl-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one | Human | Show | |
| IRAK4 | IRAK | TKL | 7qg2 | A | B | 6-methyl-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one | Human | Show | |
| IRAK4 | IRAK | TKL | 7qg3 | A | 6-[(2~{s})-2-fluoranylpropyl]-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one | Human | Show | | |
| IRAK4 | IRAK | TKL | 7qg5 | A | A | 4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-pyrimidin-5-yl-pyrido[4,3-d]pyrimidin-5-one | Human | Show | |
| IRAK4 | IRAK | TKL | 7qg5 | A | B | 4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-pyrimidin-5-yl-pyrido[4,3-d]pyrimidin-5-one | Human | Show | |
| IRAK4 | IRAK | TKL | 8atb | A | A | ~{n}-[6-ethoxy-2-[2-(4-methylpiperazin-1-yl)-2-oxidanylidene-ethyl]indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | Show | |
| IRAK4 | IRAK | TKL | 8atb | A | B | ~{n}-[6-ethoxy-2-[2-(4-methylpiperazin-1-yl)-2-oxidanylidene-ethyl]indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | Show | |
