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Updated: 01-Nov-2025

Browse kinase entries (page 251 of 282)

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#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganism DetailsFile
ROCK1DMPKAGC5wnfDA1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamideHumanShow
ROCK1DMPKAGC5wnfDB1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamideHumanShow
ROCK1DMPKAGC5wngA(2r)-n-(3-cyanophenyl)-2-(3-{[(6s)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamideHumanShow
ROCK1DMPKAGC5wngB(2r)-n-(3-cyanophenyl)-2-(3-{[(6s)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamideHumanShow
ROCK1DMPKAGC5wngC(2r)-n-(3-cyanophenyl)-2-(3-{[(6s)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamideHumanShow
ROCK1DMPKAGC5wngD(2r)-n-(3-cyanophenyl)-2-(3-{[(6s)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamideHumanShow
ROCK1DMPKAGC5wnhA(2r)-n-(3-cyanophenyl)-2-{3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}pyrrolidine-1-carboxamideHumanShow
ROCK1DMPKAGC5wnhB(2r)-n-(3-cyanophenyl)-2-{3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}pyrrolidine-1-carboxamideHumanShow
ROCK1DMPKAGC5wnhC(2r)-n-(3-cyanophenyl)-2-{3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}pyrrolidine-1-carboxamideHumanShow
ROCK1DMPKAGC5wnhD(2r)-n-(3-cyanophenyl)-2-{3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}pyrrolidine-1-carboxamideHumanShow
ROCK1DMPKAGC6e9wAn-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamideHumanShow
ROCK1DMPKAGC6e9wBn-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamideHumanShow
ROCK1DMPKAGC7jouAn-[(1s)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1h-pyrazol-4-yl)benzamideHumanShow
ROCK1DMPKAGC7s25AA2-[3-(methoxymethyl)phenyl]-n-[4-(1h-pyrazol-4-yl)phenyl]acetamideHumanShow
ROCK1DMPKAGC7s25AB2-[3-(methoxymethyl)phenyl]-n-[4-(1h-pyrazol-4-yl)phenyl]acetamideHumanShow
ROCK1DMPKAGC7s26A2-[methyl(phenyl)amino]-1-[4-(1h-pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydropyridin-1(2h)-yl]ethan-1-oneHumanShow
ROCK1DMPKAGC8zh5A-HumanShow
ROCK2DMPKAGC4l6qA6-[4-(aminomethyl)-2-fluorophenoxy]-2,1-benzoxaborol-1(3h)-olHumanShow
ROCK2DMPKAGC4l6qB6-[4-(aminomethyl)-2-fluorophenoxy]-2,1-benzoxaborol-1(3h)-olHumanShow
ROCK2DMPKAGC4wotAmethyl 3-[({2'-(aminomethyl)-5'-[(3-fluoropyridin-4-yl)carbamoyl]biphenyl-3-yl}carbonyl)amino]-4-fluorobenzoateHumanShow
ROCK2DMPKAGC4wotBmethyl 3-[({2'-(aminomethyl)-5'-[(3-fluoropyridin-4-yl)carbamoyl]biphenyl-3-yl}carbonyl)amino]-4-fluorobenzoateHumanShow
ROCK2DMPKAGC4wotCmethyl 3-[({2'-(aminomethyl)-5'-[(3-fluoropyridin-4-yl)carbamoyl]biphenyl-3-yl}carbonyl)amino]-4-fluorobenzoateHumanShow
ROCK2DMPKAGC4wotDmethyl 3-[({2'-(aminomethyl)-5'-[(3-fluoropyridin-4-yl)carbamoyl]biphenyl-3-yl}carbonyl)amino]-4-fluorobenzoateHumanShow
ROCK2DMPKAGC5u7qA-HumanShow
ROCK2DMPKAGC5u7qB-HumanShow
ROCK2DMPKAGC5u7qC-HumanShow
ROCK2DMPKAGC5u7qD-HumanShow
ROCK2DMPKAGC5u7rA(1s,4s)-4-(4-fluorophenyl)-4-hydroxy-6'-(5-methyl-1h-pyrazol-4-yl)-1'h-spiro[cyclohexane-1,2'-thieno[3,2-d]pyrimidin]-4'(3'h)-oneHumanShow
ROCK2DMPKAGC5u7rB(1s,4s)-4-(4-fluorophenyl)-4-hydroxy-6'-(5-methyl-1h-pyrazol-4-yl)-1'h-spiro[cyclohexane-1,2'-thieno[3,2-d]pyrimidin]-4'(3'h)-oneHumanShow
ROCK2DMPKAGC5u7rC(1s,4s)-4-(4-fluorophenyl)-4-hydroxy-6'-(5-methyl-1h-pyrazol-4-yl)-1'h-spiro[cyclohexane-1,2'-thieno[3,2-d]pyrimidin]-4'(3'h)-oneHumanShow
ROCK2DMPKAGC5u7rD(1s,4s)-4-(4-fluorophenyl)-4-hydroxy-6'-(5-methyl-1h-pyrazol-4-yl)-1'h-spiro[cyclohexane-1,2'-thieno[3,2-d]pyrimidin]-4'(3'h)-oneHumanShow
ROCK2DMPKAGC6ed6An-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamideHumanShow
ROCK2DMPKAGC6ed6Bn-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamideHumanShow
ROCK2DMPKAGC6p5mAA6-(5-methyl-1h-pyrazol-4-yl)-2-[(pyrrolidin-1-yl)methyl]thieno[3,2-d]pyrimidin-4(3h)-oneHumanShow
ROCK2DMPKAGC6p5mAB6-(5-methyl-1h-pyrazol-4-yl)-2-[(pyrrolidin-1-yl)methyl]thieno[3,2-d]pyrimidin-4(3h)-oneHumanShow
ROCK2DMPKAGC6p5mBA6-(5-methyl-1h-pyrazol-4-yl)-2-[(pyrrolidin-1-yl)methyl]thieno[3,2-d]pyrimidin-4(3h)-oneHumanShow
ROCK2DMPKAGC6p5mBB6-(5-methyl-1h-pyrazol-4-yl)-2-[(pyrrolidin-1-yl)methyl]thieno[3,2-d]pyrimidin-4(3h)-oneHumanShow
ROCK2DMPKAGC6p5mCA-HumanShow
ROCK2DMPKAGC6p5mCB-HumanShow
ROCK2DMPKAGC6p5mDA-HumanShow
ROCK2DMPKAGC6p5mDB-HumanShow
ROCK2DMPKAGC6p5pA2-[(2s)-1-azabicyclo[2.2.2]octan-2-yl]-6-(5-methyl-1h-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-oneHumanShow
ROCK2DMPKAGC6p5pB2-[(2s)-1-azabicyclo[2.2.2]octan-2-yl]-6-(5-methyl-1h-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-oneHumanShow
ROCK2DMPKAGC6p5pC2-[(2s)-1-azabicyclo[2.2.2]octan-2-yl]-6-(5-methyl-1h-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-oneHumanShow
ROCK2DMPKAGC6p5pD2-[(2s)-1-azabicyclo[2.2.2]octan-2-yl]-6-(5-methyl-1h-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-oneHumanShow
ROCK2DMPKAGC7jntAAn-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamideHumanShow
ROCK2DMPKAGC7jntABn-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamideHumanShow
ROCK2DMPKAGC7jntBAn-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamideHumanShow
ROCK2DMPKAGC7jntBBn-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamideHumanShow
ROCK2DMPKAGC7jntCAn-[(3-methoxyphenyl)methyl]-5h-[1]benzopyrano[3,4-c]pyridine-8-carboxamideHumanShow
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