Search results (47 entries covering 31 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	CDK8	CDK	CMGC	5hvy	A	B	n-{(3s)-1-[2-(methylamino)pyrimidin-4-yl]pyrrolidin-3-yl}-n'-{4-[(morpholin-4-yl)methyl]-3-(trifluoromethyl)phenyl}urea	Human	Show
	CDK8	CDK	CMGC	6qtj	A		~{n},~{n}-dimethyl-2-[4-[4-(2,6-naphthyridin-4-yl)phenyl]pyrazol-1-yl]ethanamide	Human	Show
	CDK8	CDK	CMGC	4f7j	A	A	1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(2-hydroxyethyl)urea	Human	Show
	CDK8	CDK	CMGC	5hnb	A	B	[6-hydroxy-3-(3-methylbenzyl)-1h-indazol-5-yl][(3s)-3-hydroxypyrrolidin-1-yl]methanone	Human	Show
	CDK8	CDK	CMGC	5fgk	A	B	8-[3-(3-azanyl-2~{h}-indazol-6-yl)-5-chloranyl-pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one	Human	Show
	CDK8	CDK	CMGC	5xqx	A		n-methyl-4-pyridin-4-yl-1h-pyrrole-2-carboxamide	Human	Show
	CDK8	CDK	CMGC	4f70	A		1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[2-(morpholin-4-yl)ethyl]urea	Human	Show
	CDK8	CDK	CMGC	6t41	A		~{n}-[(4-chlorophenyl)methyl]quinazolin-4-amine	Human	Show
	CDK8	CDK	CMGC	5idp	A	B	(3-amino-1h-indazol-5-yl)[(2s)-2-(4-fluorophenyl)piperidin-1-yl]methanone	Human	Show
	CDK8	CDK	CMGC	6tpa	A		1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-(5-oxidanylidene-6-pyridin-4-yl-pyrido[2,3-b][1,5]benzoxazepin-9-yl)urea	Human	Show
	CDK8	CDK	CMGC	5xs2	A	B	3-chloranyl-4-pyridin-4-yl-1h-pyrrole-2-carboxamide	Human	Show
	CDK8	CDK	CMGC	4crl	A		cortistatin a	Human	Show
	CDK8	CDK	CMGC	4g6l	A		-	Human	Show
	CDK8	CDK	CMGC	5idp	A	A	(3-amino-1h-indazol-5-yl)[(2s)-2-(4-fluorophenyl)piperidin-1-yl]methanone	Human	Show
	CDK8	CDK	CMGC	5fgk	A	A	8-[3-(3-azanyl-2~{h}-indazol-6-yl)-5-chloranyl-pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one	Human	Show
	CDK8	CDK	CMGC	6r3s	A	B	6-[5-chloranyl-4-[(1~{s})-1-oxidanylethyl]pyridin-3-yl]-3,4-dihydro-2~{h}-1,8-naphthyridine-1-carboxamide	Human	Show
	CDK8	CDK	CMGC	6y0a	A	B	6-[5-chloranyl-4-[(1~{s})-1-oxidanylethyl]pyridin-3-yl]-3,4-dihydro-2~{h}-1,8-naphthyridine-1-carboxamide	Human	Show
	CDK8	CDK	CMGC	5hvy	A	A	n-{(3s)-1-[2-(methylamino)pyrimidin-4-yl]pyrrolidin-3-yl}-n'-{4-[(morpholin-4-yl)methyl]-3-(trifluoromethyl)phenyl}urea	Human	Show
	CDK8	CDK	CMGC	5hbj	A	A	8-[2-azanyl-3-chloranyl-5-(1-methylindazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one	Human	Show
	CDK8	CDK	CMGC	3rgf	A	A	4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide	Human	Show
	CDK8	CDK	CMGC	4f6u	A	A	1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(morpholin-4-yl)propyl]urea	Human	Show
	CDK8	CDK	CMGC	4f7j	A	B	1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(2-hydroxyethyl)urea	Human	Show
	CDK8	CDK	CMGC	4f7s	A	B	n-(2-phenylethyl)quinazolin-4-amine	Human	Show
	CDK8	CDK	CMGC	5bnj	A		8-{3-chloro-5-[4-(1-methyl-1h-pyrazol-4-yl)phenyl]pyridin-4-yl}-2,8-diazaspiro[4.5]decan-1-one	Human	Show
	CDK8	CDK	CMGC	4f7n	A		1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(5-hydroxypentyl)urea	Human	Show
	CDK8	CDK	CMGC	5hnb	A	A	[6-hydroxy-3-(3-methylbenzyl)-1h-indazol-5-yl][(3s)-3-hydroxypyrrolidin-1-yl]methanone	Human	Show
	CDK8	CDK	CMGC	6qtg	A		2-[4-(4-isoquinolin-4-ylphenyl)pyrazol-1-yl]-~{n},~{n}-dimethyl-ethanamide	Human	Show
	CDK8	CDK	CMGC	5i5z	A		n-methyl-8-(1-methyl-2,2-dioxo-2,3-dihydro-1h-2lambda~6~,1-benzothiazol-5-yl)-1,6-naphthyridine-2-carboxamide	Human	Show
	CDK8	CDK	CMGC	5idn	A	A	[(2s)-2-(4-chlorophenyl)pyrrolidin-1-yl](3-methyl-1h-pyrazolo[3,4-b]pyridin-5-yl)methanone	Human	Show
	CDK8	CDK	CMGC	4f7s	A	A	n-(2-phenylethyl)quinazolin-4-amine	Human	Show
	CDK8	CDK	CMGC	5hbh	A		5-[5-chloranyl-4-[1-(2-methoxyethyl)-1,8-diazaspiro[4.5]decan-8-yl]pyridin-3-yl]-1-methyl-3~{h}-2,1-benzothiazole 2,2-dioxide	Human	Show
	CDK8	CDK	CMGC	5icp	A	B	[(2s)-2-(4-chlorophenyl)pyrrolidin-1-yl](5-methylimidazo[5,1-b][1,3,4]thiadiazol-2-yl)methanone	Human	Show
	CDK8	CDK	CMGC	6y0a	A	A	6-[5-chloranyl-4-[(1~{s})-1-oxidanylethyl]pyridin-3-yl]-3,4-dihydro-2~{h}-1,8-naphthyridine-1-carboxamide	Human	Show
	CDK8	CDK	CMGC	5hbe	A	A	8-[3-chloranyl-5-[1-methyl-2,2-bis(oxidanylidene)-3~{h}-2,1-benzothiazol-5-yl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one	Human	Show
	CDK8	CDK	CMGC	4f6s	A		1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]urea	Human	Show
	CDK8	CDK	CMGC	3rgf	A	B	4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide	Human	Show
	CDK8	CDK	CMGC	4f7l	A		tert-butyl [3-({[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]carbamoyl}amino)propyl]carbamate	Human	Show
	CDK8	CDK	CMGC	4f6u	A	B	1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(morpholin-4-yl)propyl]urea	Human	Show
	CDK8	CDK	CMGC	5cei	A	B	4-(4-iodophenoxy)-n-methylthieno[2,3-c]pyridine-2-carboxamide	Human	Show
	CDK8	CDK	CMGC	5icp	A	A	[(2s)-2-(4-chlorophenyl)pyrrolidin-1-yl](5-methylimidazo[5,1-b][1,3,4]thiadiazol-2-yl)methanone	Human	Show
	CDK8	CDK	CMGC	5xs2	A	A	3-chloranyl-4-pyridin-4-yl-1h-pyrrole-2-carboxamide	Human	Show
	CDK8	CDK	CMGC	5idn	A	B	[(2s)-2-(4-chlorophenyl)pyrrolidin-1-yl](3-methyl-1h-pyrazolo[3,4-b]pyridin-5-yl)methanone	Human	Show
	CDK8	CDK	CMGC	5hbj	A	B	8-[2-azanyl-3-chloranyl-5-(1-methylindazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one	Human	Show
	CDK8	CDK	CMGC	6r3s	A	A	6-[5-chloranyl-4-[(1~{s})-1-oxidanylethyl]pyridin-3-yl]-3,4-dihydro-2~{h}-1,8-naphthyridine-1-carboxamide	Human	Show
	CDK8	CDK	CMGC	4f6w	A		n-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-4-[2-({[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]carbamoyl}amino)ethyl]piperazine-1-carboxamide	Human	Show
	CDK8	CDK	CMGC	5cei	A	A	4-(4-iodophenoxy)-n-methylthieno[2,3-c]pyridine-2-carboxamide	Human	Show
	CDK8	CDK	CMGC	5hbe	A	B	8-[3-chloranyl-5-[1-methyl-2,2-bis(oxidanylidene)-3~{h}-2,1-benzothiazol-5-yl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam