Search results (50 entries covering 29 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	NEK2	NEK	Other	4afe	A		4-(2-amino-5-{4-[(dimethylamino)methyl]thiophen-2-yl}pyridin-3-yl)-2-{[(1r,2z)-4,4,4-trifluoro-1-methylbut-2-en-1-yl]oxy}benzamide	Human	Show
	NEK2	NEK	Other	5m55	A	A	6-[(~{z})-2-(diethylamino)ethenyl]-~{n}-phenyl-7~{h}-purin-2-amine	Human	Show
	NEK2	NEK	Other	2xkd	A	A	4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]benzoic acid	Human	Show
	NEK2	NEK	Other	2xnm	A	B	5-{6-[(1-methylpiperidin-4-yl)oxy]-1h-benzimidazol-1-yl}-3-{(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide	Human	Show
	NEK2	NEK	Other	2w5b	A	B	phosphothiophosphoric acid-adenylate ester	Human	Show
	NEK2	NEK	Other	6sgh	A	B	2-[4-[(6-ethenyl-9~{h}-purin-2-yl)amino]phenyl]ethanamide	Human	Show
	NEK2	NEK	Other	2jav	A	B	5-[(z)-(5-chloro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-n-(diethylamino)ethyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide	Human	Show
	NEK2	NEK	Other	6sgh	A	A	2-[4-[(6-ethenyl-9~{h}-purin-2-yl)amino]phenyl]ethanamide	Human	Show
	NEK2	NEK	Other	2xk4	A	C	4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-ethoxybenzoic acid	Human	Show
	NEK2	NEK	Other	2xk7	A	B	(3r,4r)-1-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-3-ethylpiperidine-4-carboxylic acid	Human	Show
	NEK2	NEK	Other	2xk4	A	A	4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-ethoxybenzoic acid	Human	Show
	NEK2	NEK	Other	2xnn	A	A	5-(1h-benzimidazol-1-yl)-3-{(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide	Human	Show
	NEK2	NEK	Other	6sk9	A	A	3-[[6-(cyclohexylmethoxy)-7~{h}-purin-2-yl]amino]-~{n}-[3-(dimethylamino)propyl]benzenesulfonamide	Human	Show
	NEK2	NEK	Other	2w5h	A	A	-	Human	Show
	NEK2	NEK	Other	2xk7	A	A	(3r,4r)-1-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-3-ethylpiperidine-4-carboxylic acid	Human	Show
	NEK2	NEK	Other	2xk3	A	A	4-[3-amino-6-(3-ethylthiophen-2-yl)pyrazin-2-yl]cyclohexane-1-carboxylic acid	Human	Show
	NEK2	NEK	Other	2w5a	A	A	adenosine-5'-diphosphate	Human	Show
	NEK2	NEK	Other	2xkc	A	B	4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-methylbenzoic acid	Human	Show
	NEK2	NEK	Other	2xke	A		1-[3-amino-6-(3-methoxyphenyl)pyrazin-2-yl]piperidine-4-carboxylic acid	Human	Show
	NEK2	NEK	Other	2xkc	A	A	4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-methylbenzoic acid	Human	Show
	NEK2	NEK	Other	2xk8	A		4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-methoxybenzoic acid	Human	Show
	NEK2	NEK	Other	2jav	A	A	5-[(z)-(5-chloro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-n-(diethylamino)ethyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide	Human	Show
	NEK2	NEK	Other	2xno	A	A	5-{6-[(1-methylpiperidin-4-yl)oxy]-1h-benzimidazol-1-yl}-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxamide	Human	Show
	NEK2	NEK	Other	4a4x	A		4-(2-amino-5-{4-[(dimethylamino)methyl]thiophen-2-yl}pyridin-3-yl)-2-{(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy}benzamide	Human	Show
	NEK2	NEK	Other	6sgd	A	A	4-[(6-ethenyl-7~{h}-purin-2-yl)amino]benzenesulfonamide	Human	Show
	NEK2	NEK	Other	2w5h	A	B	-	Human	Show
	NEK2	NEK	Other	2xnn	A	B	5-(1h-benzimidazol-1-yl)-3-{(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide	Human	Show
	NEK2	NEK	Other	2xk3	A	B	4-[3-amino-6-(3-ethylthiophen-2-yl)pyrazin-2-yl]cyclohexane-1-carboxylic acid	Human	Show
	NEK2	NEK	Other	5m55	A	B	6-[(~{z})-2-(diethylamino)ethenyl]-~{n}-phenyl-7~{h}-purin-2-amine	Human	Show
	NEK2	NEK	Other	5m57	A		o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	Show
	NEK2	NEK	Other	2w5b	A	A	phosphothiophosphoric acid-adenylate ester	Human	Show
	NEK2	NEK	Other	6sgd	A	B	4-[(6-ethenyl-7~{h}-purin-2-yl)amino]benzenesulfonamide	Human	Show
	NEK2	NEK	Other	2xnp	A	B	4-{5-[(1-methylpiperidin-4-yl)oxy]-1h-benzimidazol-1-yl}-2-{(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy}benzamide	Human	Show
	NEK2	NEK	Other	2xkf	A	B	1-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]piperidine-4-carboxylic acid	Human	Show
	NEK2	NEK	Other	2xkf	A	A	1-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]piperidine-4-carboxylic acid	Human	Show
	NEK2	NEK	Other	5m53	A	A	3-[[6-(cyclohexylmethoxy)-7~{h}-purin-2-yl]amino]-~{n},~{n}-dimethyl-benzamide	Human	Show
	NEK2	NEK	Other	2xk4	A	B	4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-ethoxybenzoic acid	Human	Show
	NEK2	NEK	Other	2w5a	A	B	adenosine-5'-diphosphate	Human	Show
	NEK2	NEK	Other	6sgk	A		2-phenylazanyl-9~{h}-purine-6-carbonitrile	Human	Show
	NEK2	NEK	Other	2wqo	A		4-[2-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]benzoic acid	Human	Show
	NEK2	NEK	Other	6sgi	A	A	4-[(6-ethyl-7~{h}-purin-2-yl)amino]benzenesulfonamide	Human	Show
	NEK2	NEK	Other	6sk9	A	B	3-[[6-(cyclohexylmethoxy)-7~{h}-purin-2-yl]amino]-~{n}-[3-(dimethylamino)propyl]benzenesulfonamide	Human	Show
	NEK2	NEK	Other	5m51	A		3-[[6-(cyclohexylmethoxy)-9~{h}-purin-2-yl]amino]benzamide	Human	Show
	NEK2	NEK	Other	2xno	A	B	5-{6-[(1-methylpiperidin-4-yl)oxy]-1h-benzimidazol-1-yl}-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxamide	Human	Show
	NEK2	NEK	Other	5m53	A	B	3-[[6-(cyclohexylmethoxy)-7~{h}-purin-2-yl]amino]-~{n},~{n}-dimethyl-benzamide	Human	Show
	NEK2	NEK	Other	6sgi	A	B	4-[(6-ethyl-7~{h}-purin-2-yl)amino]benzenesulfonamide	Human	Show
	NEK2	NEK	Other	2xnp	A	A	4-{5-[(1-methylpiperidin-4-yl)oxy]-1h-benzimidazol-1-yl}-2-{(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy}benzamide	Human	Show
	NEK2	NEK	Other	2xkd	A	B	4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]benzoic acid	Human	Show
	NEK2	NEK	Other	2xnm	A	A	5-{6-[(1-methylpiperidin-4-yl)oxy]-1h-benzimidazol-1-yl}-3-{(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide	Human	Show
	NEK2	NEK	Other	2xk6	A		cis-4-[3-amino-6-(3-cyclopropylthiophen-2-yl)pyrazin-2-yl]cyclohexanecarboxylic acid	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam