Search results (83 entries covering 75 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	TTK	TTK	Other	5nad	A		bay 1217389	Human	Show
	TTK	TTK	Other	6tnd	A	B	bay 1217389	Human	Show
	TTK	TTK	Other	3h9f	A	B	9-cyclopentyl-2-(4-(4-hydroxypiperidin-1-yl)-2-methoxyphenylamino)-5-methyl-8,9-dihydro-5h-pyrimido[4,5-b][1,4]diazepin-6(7h)-one	Human	Show
	TTK	TTK	Other	5ei8	A		~{n}-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]-8-(1-methylpyrazol-4-yl)pyrido[3,4-d]pyrimidin-2-amine	Human	Show
	TTK	TTK	Other	6b4w	A		4-{[4-(cyclopentyloxy)-5-(2-methyl-1,3-benzoxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-3-methoxy-n-methylbenzamide	Human	Show
	TTK	TTK	Other	5n7v	A		~{n}6-cyclohexyl-~{n}2-(2-methyl-4-morpholin-4-yl-phenyl)-7~{h}-purine-2,6-diamine	Human	Show
	TTK	TTK	Other	4bi1	A		thieno[3,2-c][2,6]naphthyridine	Human	Show
	TTK	TTK	Other	5ljj	A		n~6~-cyclohexyl-n~2~-(4-morpholin-4-ylphenyl)-9h-purine-2,6-diamine	Human	Show
	TTK	TTK	Other	3h9f	A	A	9-cyclopentyl-2-(4-(4-hydroxypiperidin-1-yl)-2-methoxyphenylamino)-5-methyl-8,9-dihydro-5h-pyrimido[4,5-b][1,4]diazepin-6(7h)-one	Human	Show
	TTK	TTK	Other	5ehy	A		4-(furan-3-yl)-3-phenyl-2~{h}-pyrazolo[4,3-c]pyridine	Human	Show
	TTK	TTK	Other	7chn	A		4-(cyclohexylamino)-2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-7h-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	Human	Show
	TTK	TTK	Other	3wzk	A		n-cyclopropyl-4-{8-[(thiophen-2-ylmethyl)amino]imidazo[1,2-a]pyrazin-3-yl}benzamide	Human	Show
	TTK	TTK	Other	3hmo	A		staurosporine	Human	Show
	TTK	TTK	Other	7cil	A	B	4-(cyclohexylamino)-2-[(1-methylpyrazol-4-yl)amino]-7h-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	Human	Show
	TTK	TTK	Other	5ap3	A		9-cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8h-purin-8-one	Human	Show
	TTK	TTK	Other	7cil	A	A	4-(cyclohexylamino)-2-[(1-methylpyrazol-4-yl)amino]-7h-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	Human	Show
	TTK	TTK	Other	4o6l	A		n-[(1r)-1-(2-chlorophenyl)propyl]-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-1h-indazole-5-carboxamide	Human	Show
	TTK	TTK	Other	7clh	A		2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-4-(methylamino)-7h-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	Human	Show
	TTK	TTK	Other	2zmd	A		2,6-dihydroanthra/1,9-cd/pyrazol-6-one	Human	Show
	TTK	TTK	Other	5n93	A		4-[[4-azanyl-6-(~{tert}-butylamino)-5-cyano-pyridin-2-yl]amino]benzamide	Human	Show
	TTK	TTK	Other	5n84	A		~{n}-cyclopropyl-4-[8-(2-methylpropylamino)imidazo[1,2-a]pyrazin-3-yl]benzamide	Human	Show
	TTK	TTK	Other	5na0	A		~{n}-[3,5-diethyl-1-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]pyrazol-4-yl]-2-[[2-methoxy-4-[4-(2-methoxyethanoyl)piperazin-1-yl]phenyl]amino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide	Human	Show
	TTK	TTK	Other	5ap6	A	A	isopropyl 6-((4-(1,2-dimethyl-1h-imidazol-5-yl)phenyl)amino)-2-(1-methyl-1h-pyrazol-4-yl)-1h-pyrrolo[3,2-c]pyridine-1-carboxylate	Human	Show
	TTK	TTK	Other	5ap0	A		9-cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8h-purin-8-one	Human	Show
	TTK	TTK	Other	4jt3	A		2-phenyl-n-[3-(3-sulfamoylphenyl)-2h-indazol-5-yl]acetamide	Human	Show
	TTK	TTK	Other	5n9s	A		(2~{r})-2-(4-fluorophenyl)-~{n}-[4-[2-[(2-methoxy-4-methylsulfonyl-phenyl)amino]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]propanamide	Human	Show
	TTK	TTK	Other	4c4e	A	B	-	Human	Show
	TTK	TTK	Other	4o6l	B		n-[(1r)-1-(2-chlorophenyl)propyl]-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-1h-indazole-5-carboxamide	Human	Show
	TTK	TTK	Other	5eh0	A		n2-(2-methoxy-4-(1-methyl-1h-pyrazol-4-yl)phenyl)-n8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine	Human	Show
	TTK	TTK	Other	4d2s	A		n-{2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}-4-(1h-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine	Human	Show
	TTK	TTK	Other	3hmp	A		7-chloro-n-(cyclopropylmethyl)quinazolin-4-amine	Human	Show
	TTK	TTK	Other	5ap7	A		n-(2,6-diethylphenyl)-1-methyl-8-({4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide	Human	Show
	TTK	TTK	Other	5ap2	A		isopropyl 6-((4-(1,2-dimethyl-1h-imidazol-5-yl)phenyl)amino)-2-(1-methyl-1h-pyrazol-4-yl)-1h-pyrrolo[3,2-c]pyridine-1-carboxylate	Human	Show
	TTK	TTK	Other	4zeg	A		n-cyclopropyl-2-methyl-4-(7-{[2-(morpholin-4-yl)ethyl]amino}-5-phenoxypyrazolo[1,5-a]pyrimidin-3-yl)benzamide	Human	Show
	TTK	TTK	Other	7lqd	A		~{n}-(2,6-diethylphenyl)-2-[[4-(4-methylpiperazin-1-yl)-2-(propanoylamino)phenyl]amino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide	Human	Show
	TTK	TTK	Other	5ap5	A		tert-butyl 6-((2-chloro-4-(dimethylcarbamoyl)phenyl)amino)-2-(1-methyl-1h-pyrazol-4-yl)-1h-pyrrolo[3,2-c]pyridine-1-carboxylate	Human	Show
	TTK	TTK	Other	5eho	A		~{n}8-cyclohexyl-~{n}2-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamine	Human	Show
	TTK	TTK	Other	6gvj	A		-	Human	Show
	TTK	TTK	Other	4bi0	A		5h-pyrimido[5,4-b]indole	Human	Show
	TTK	TTK	Other	5ntt	A	B	n-(2,6-diethylphenyl)-1-methyl-8-({4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide	Human	Show
	TTK	TTK	Other	3gfw	A		1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1h-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol	Human	Show
	TTK	TTK	Other	5ehl	A		1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]urea	Human	Show
	TTK	TTK	Other	5mrb	A		~{n}-(2,6-diethylphenyl)-8-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	Human	Show
	TTK	TTK	Other	4c4i	A		tert-butyl 6-{[2-chloro-4-(dimethylcarbamoyl)phenyl]amino}-2-(1,3-oxazol-5-yl)-1h-pyrrolo[3,2-c]pyridine-1-carboxylate	Human	Show
	TTK	TTK	Other	3wyy	A		(2e)-3-[4-({4-amino-5-cyano-6-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-ylamino]pyridin-2-yl}amino)-2-(cyanomethoxy)phenyl]-n-(2-methoxyethyl)prop-2-enamide	Human	Show
	TTK	TTK	Other	6tnb	A		(2~{r})-2-(4-fluorophenyl)-~{n}-[4-[2-[(2-methoxy-4-methylsulfonyl-phenyl)amino]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]propanamide	Human	Show
	TTK	TTK	Other	3wyx	A		6-{[3-(cyanomethoxy)-4-(1-methyl-1h-pyrazol-4-yl)phenyl]amino}-2-(cyclohexylamino)pyridine-3-carbonitrile	Human	Show
	TTK	TTK	Other	5ei6	A		~{n}-(2,4-dimethoxyphenyl)-5-(1-methylpyrazol-4-yl)isoquinolin-3-amine	Human	Show
	TTK	TTK	Other	6h3k	A		~{n}8-(2,2-dimethylpropyl)-~{n}2-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methyl-pyrido[3,4-d]pyrimidine-2,8-diamine	Human	Show
	TTK	TTK	Other	4bi2	A		thieno[2,3-c][2,7]naphthyridine	Human	Show
	TTK	TTK	Other	2x9e	A		n-(2,6-diethylphenyl)-1-methyl-8-({4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide	Human	Show
	TTK	TTK	Other	7chm	A		4-(cyclohexylamino)-2-[(2-methoxy-4-morpholin-4-ylcarbonyl-phenyl)amino]-7h-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	Human	Show
	TTK	TTK	Other	5n87	A		~{n}-(2,6-diethylphenyl)-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide	Human	Show
	TTK	TTK	Other	4c4e	A	A	n-(3,4-dimethoxyphenyl)-2-(1h-pyrazol-4-yl)-1h-pyrrolo[3,2-c]pyridin-6-amine	Human	Show
	TTK	TTK	Other	3w1f	A		5-[5-ethoxy-6-(1-methyl-1h-pyrazol-4-yl)-1h-indazol-3-yl]-2-methylbenzenesulfonamide	Human	Show
	TTK	TTK	Other	4c4j	A		tert-butyl 6-{[2-chloro-4-(1-methyl-1h-imidazol-5-yl)phenyl]amino}-2-(1-methyl-1h-pyrazol-4-yl)-1h-pyrrolo[3,2-c]pyridine-1-carboxylate	Human	Show
	TTK	TTK	Other	7cja	A		4-(cyclopentylmethylamino)-2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-7h-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	Human	Show
	TTK	TTK	Other	3wzj	A		4-{6-(cyclohexylamino)-8-[(tetrahydro-2h-pyran-4-ylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl}-n-cyclopropylbenzamide	Human	Show
	TTK	TTK	Other	4c4f	A		n-(2-methoxyphenyl)-2-(1,3-oxazol-5-yl)-1h-pyrrolo[3,2-c]pyridin-6-amine	Human	Show
	TTK	TTK	Other	3hmn	A		adenosine-5'-triphosphate	Human	Show
	TTK	TTK	Other	4cva	A		n-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)-4-(piperidin-1-yl)benzamide	Human	Show
	TTK	TTK	Other	3vqu	A		4-[(4-amino-5-cyano-6-ethoxypyridin-2-yl)amino]benzamide	Human	Show
	TTK	TTK	Other	4cv9	A		4-(4-methylpiperazin-1-yl)-n-(2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin-3-yl)benzamide	Human	Show
	TTK	TTK	Other	5ap1	A		6-{[3-(cyanomethoxy)-4-(1-methyl-1h-pyrazol-4-yl)phenyl]amino}-2-(cyclohexylamino)pyridine-3-carbonitrile	Human	Show
	TTK	TTK	Other	6n6o	A		4-({5-chloro-4-[(cis-4-hydroxy-4-methylcyclohexyl)oxy]-7h-pyrrolo[2,3-d]pyrimidin-2-yl}amino)-n,n-dimethyl-3-{[(2r)-1,1,1-trifluoropropan-2-yl]oxy}benzamide	Human	Show
	TTK	TTK	Other	5ntt	A	A	n-(2,6-diethylphenyl)-1-methyl-8-({4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide	Human	Show
	TTK	TTK	Other	6tnd	A	A	bay 1217389	Human	Show
	TTK	TTK	Other	4js8	A		4-(cyclohexylmethoxy)-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-2h-indazole	Human	Show
	TTK	TTK	Other	4bhz	A		thieno[2,3-c][2,6]naphthyridine	Human	Show
	TTK	TTK	Other	7cht	A		2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-4-(oxan-4-ylamino)-7h-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	Human	Show
	TTK	TTK	Other	6tn9	A	B	[4-[[6-(3,5-dimethyl-4-oxidanyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]phenyl]-morpholin-4-yl-methanone	Human	Show
	TTK	TTK	Other	5ei2	A		~{n}-(2,4-dimethoxyphenyl)-8-(1-methylpyrazol-4-yl)pyrido[3,4-d]pyrimidin-2-amine	Human	Show
	TTK	TTK	Other	5ap4	A		6-{[3-(cyanomethoxy)-4-(1-methyl-1h-pyrazol-4-yl)phenyl]amino}-2-(cyclohexylamino)pyridine-3-carbonitrile	Human	Show
	TTK	TTK	Other	2zmc	A		-	Human	Show
	TTK	TTK	Other	5o91	A		~{n}-(2,6-diethylphenyl)-8-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide	Human	Show
	TTK	TTK	Other	4c4g	A		tert-butyl 6-((2-chloro-4-(dimethylcarbamoyl)phenyl)amino)-2-(1-methyl-1h-pyrazol-4-yl)-1h-pyrrolo[3,2-c]pyridine-1-carboxylate	Human	Show
	TTK	TTK	Other	6tnc	A		n-cyclopropyl-4-{8-[(thiophen-2-ylmethyl)amino]imidazo[1,2-a]pyrazin-3-yl}benzamide	Human	Show
	TTK	TTK	Other	6tn9	A	A	[4-[[6-(3,5-dimethyl-4-oxidanyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]phenyl]-morpholin-4-yl-methanone	Human	Show
	TTK	TTK	Other	5ap6	A	B	isopropyl 6-((4-(1,2-dimethyl-1h-imidazol-5-yl)phenyl)amino)-2-(1-methyl-1h-pyrazol-4-yl)-1h-pyrrolo[3,2-c]pyridine-1-carboxylate	Human	Show
	TTK	TTK	Other	3cek	A		-	Human	Show
	TTK	TTK	Other	4cv8	A		3-amino-5-(1-methyl-1h-pyrazol-4-yl)pyridin-2(1h)-one	Human	Show
	TTK	TTK	Other	4c4h	A		tert-butyl 6-((2-chloro-4-(dimethylcarbamoyl)phenyl)amino)-2-(1-methyl-1h-pyrazol-4-yl)-1h-pyrrolo[3,2-c]pyridine-1-carboxylate	Human	Show
	TTK	TTK	Other	3dbq	A		-	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam