Search results (77 entries covering 24 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	MAP3K5	STE11	STE	7mu7	A	B	3-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-1-(pyrazin-2-yl)-1h-pyrazole-4-carboxamide	Human	Show
	MAP3K5	STE11	STE	2clq	A	B	staurosporine	Human	Show
	MAP3K5	STE11	STE	4bid	B	A	5-[(1r)-2-amino-1-phenylethoxy]-2-(furan-3-yl)-3-{1h-pyrrolo[2,3-b]pyridin-3-yl}pyridine	Human	Show
	MAP3K5	STE11	STE	4bid	A	A	5-[(1r)-2-amino-1-phenylethoxy]-2-(furan-3-yl)-3-{1h-pyrrolo[2,3-b]pyridin-3-yl}pyridine	Human	Show
	MAP3K5	STE11	STE	8qgy	A		-	Human	Show
	MAP3K5	STE11	STE	5v19	A		n-(1-ethyl-1h-pyrazol-4-yl)furan-3-carboxamide	Human	Show
	MAP3K5	STE11	STE	6vre	A	B	3-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-1-(pyrazin-2-yl)-1h-pyrazole-4-carboxamide	Human	Show
	MAP3K5	STE11	STE	6e2o	B		4-(4-cyclopropyl-1h-imidazol-1-yl)-n-[3-(4-cyclopropyl-4h-1,2,4-triazol-3-yl)phenyl]pyridine-2-carboxamide	Human	Show
	MAP3K5	STE11	STE	6xih	A	B	(2r)-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}oxane-2-carboxamide	Human	Show
	MAP3K5	STE11	STE	4bf2	A		staurosporine	Human	Show
	MAP3K5	STE11	STE	5vil	A		2-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-5-sulfamoylbenzamide	Human	Show
	MAP3K5	STE11	STE	4bib	A	A	3-cyano-4-(piperidin-4-yloxy)-1h-indole-7-carboxamide	Human	Show
	MAP3K5	STE11	STE	4bib	B	A	3-cyano-4-(piperidin-4-yloxy)-1h-indole-7-carboxamide	Human	Show
	MAP3K5	STE11	STE	4bic	B		-	Human	Show
	MAP3K5	STE11	STE	6oyw	A	A	(19s)-19-methyl-16,17,18,19-tetrahydro-8,4-(azeno)[1,2,4]triazolo[4,3-f][1,6,13]benzoxadiazacyclohexadecin-10(9h)-one	Human	Show
	MAP3K5	STE11	STE	5uor	B		6-{[(2s)-4-methylmorpholin-2-yl]methoxy}-2-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-2,3-dihydro-1h-isoindol-1-one	Human	Show
	MAP3K5	STE11	STE	4bie	B	A	n-(2-aminoethyl)-5-{2-methyl-1h-pyrrolo[2,3-b]pyridin-4-yl}thiophene-2-sulfonamide	Human	Show
	MAP3K5	STE11	STE	6oyw	D	B	(19s)-19-methyl-16,17,18,19-tetrahydro-8,4-(azeno)[1,2,4]triazolo[4,3-f][1,6,13]benzoxadiazacyclohexadecin-10(9h)-one	Human	Show
	MAP3K5	STE11	STE	6oyw	B	B	(19s)-19-methyl-16,17,18,19-tetrahydro-8,4-(azeno)[1,2,4]triazolo[4,3-f][1,6,13]benzoxadiazacyclohexadecin-10(9h)-one	Human	Show
	MAP3K5	STE11	STE	6vre	B	B	3-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-1-(pyrazin-2-yl)-1h-pyrazole-4-carboxamide	Human	Show
	MAP3K5	STE11	STE	5vio	C		-	Human	Show
	MAP3K5	STE11	STE	4bhn	B	A	4-tert-butyl-n-[6-(1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-2-yl]benzamide	Human	Show
	MAP3K5	STE11	STE	5v24	B	A	2-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]-n-(pyridin-2-yl)-1,3-thiazole-4-carboxamide	Human	Show
	MAP3K5	STE11	STE	3vw6	A	A	4-tert-butyl-n-[6-(1h-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide	Human	Show
	MAP3K5	STE11	STE	6e2o	A		4-(4-cyclopropyl-1h-imidazol-1-yl)-n-[3-(4-cyclopropyl-4h-1,2,4-triazol-3-yl)phenyl]pyridine-2-carboxamide	Human	Show
	MAP3K5	STE11	STE	6oyw	C	B	(19s)-19-methyl-16,17,18,19-tetrahydro-8,4-(azeno)[1,2,4]triazolo[4,3-f][1,6,13]benzoxadiazacyclohexadecin-10(9h)-one	Human	Show
	MAP3K5	STE11	STE	5up3	A		2-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-2,3-dihydro-1h-isoindol-1-one	Human	Show
	MAP3K5	STE11	STE	6oyw	A	B	(19s)-19-methyl-16,17,18,19-tetrahydro-8,4-(azeno)[1,2,4]triazolo[4,3-f][1,6,13]benzoxadiazacyclohexadecin-10(9h)-one	Human	Show
	MAP3K5	STE11	STE	4bie	A	B	n-(2-aminoethyl)-5-{2-methyl-1h-pyrrolo[2,3-b]pyridin-4-yl}thiophene-2-sulfonamide	Human	Show
	MAP3K5	STE11	STE	5uor	A		6-{[(2s)-4-methylmorpholin-2-yl]methoxy}-2-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-2,3-dihydro-1h-isoindol-1-one	Human	Show
	MAP3K5	STE11	STE	5uox	A		2-(6-{4-[(2r)-1-hydroxypropan-2-yl]-4h-1,2,4-triazol-3-yl}pyridin-2-yl)-6-[(propan-2-yl)oxy]-2,3-dihydro-1h-isoindol-1-one	Human	Show
	MAP3K5	STE11	STE	4bie	A	A	n-(2-aminoethyl)-5-{2-methyl-1h-pyrrolo[2,3-b]pyridin-4-yl}thiophene-2-sulfonamide	Human	Show
	MAP3K5	STE11	STE	4bhn	A	A	4-tert-butyl-n-[6-(1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-2-yl]benzamide	Human	Show
	MAP3K5	STE11	STE	6oyt	A		5-(4-cyclopropyl-1h-imidazol-1-yl)-2-fluoro-4-methyl-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}benzamide	Human	Show
	MAP3K5	STE11	STE	6xih	B	B	(2r)-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}oxane-2-carboxamide	Human	Show
	MAP3K5	STE11	STE	6vre	B	A	3-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-1-(pyrazin-2-yl)-1h-pyrazole-4-carboxamide	Human	Show
	MAP3K5	STE11	STE	6e2n	A		n-[3-(4-cyclopropyl-4h-1,2,4-triazol-3-yl)phenyl][3,4'-bipyridine]-2'-carboxamide	Human	Show
	MAP3K5	STE11	STE	3vw6	A	B	4-tert-butyl-n-[6-(1h-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide	Human	Show
	MAP3K5	STE11	STE	5v24	A	B	2-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]-n-(pyridin-2-yl)-1,3-thiazole-4-carboxamide	Human	Show
	MAP3K5	STE11	STE	3vw6	B	A	4-tert-butyl-n-[6-(1h-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide	Human	Show
	MAP3K5	STE11	STE	6oyt	B		5-(4-cyclopropyl-1h-imidazol-1-yl)-2-fluoro-4-methyl-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}benzamide	Human	Show
	MAP3K5	STE11	STE	6oyw	C	A	(19s)-19-methyl-16,17,18,19-tetrahydro-8,4-(azeno)[1,2,4]triazolo[4,3-f][1,6,13]benzoxadiazacyclohexadecin-10(9h)-one	Human	Show
	MAP3K5	STE11	STE	6xih	B	A	(2r)-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}oxane-2-carboxamide	Human	Show
	MAP3K5	STE11	STE	3vw6	B	B	4-tert-butyl-n-[6-(1h-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide	Human	Show
	MAP3K5	STE11	STE	6oyw	D	A	(19s)-19-methyl-16,17,18,19-tetrahydro-8,4-(azeno)[1,2,4]triazolo[4,3-f][1,6,13]benzoxadiazacyclohexadecin-10(9h)-one	Human	Show
	MAP3K5	STE11	STE	4bie	B	B	n-(2-aminoethyl)-5-{2-methyl-1h-pyrrolo[2,3-b]pyridin-4-yl}thiophene-2-sulfonamide	Human	Show
	MAP3K5	STE11	STE	6e2n	B		n-[3-(4-cyclopropyl-4h-1,2,4-triazol-3-yl)phenyl][3,4'-bipyridine]-2'-carboxamide	Human	Show
	MAP3K5	STE11	STE	5vio	A		4-methoxy-n~1~-methyl-n~3~-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}benzene-1,3-dicarboxamide	Human	Show
	MAP3K5	STE11	STE	2clq	A	A	staurosporine	Human	Show
	MAP3K5	STE11	STE	6oyt	D		5-(4-cyclopropyl-1h-imidazol-1-yl)-2-fluoro-4-methyl-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}benzamide	Human	Show
	MAP3K5	STE11	STE	4bib	B	B	3-cyano-4-(piperidin-4-yloxy)-1h-indole-7-carboxamide	Human	Show
	MAP3K5	STE11	STE	4bhn	A	B	4-tert-butyl-n-[6-(1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-2-yl]benzamide	Human	Show
	MAP3K5	STE11	STE	5vio	D		4-methoxy-n~1~-methyl-n~3~-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}benzene-1,3-dicarboxamide	Human	Show
	MAP3K5	STE11	STE	5vio	B		4-methoxy-n~1~-methyl-n~3~-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}benzene-1,3-dicarboxamide	Human	Show
	MAP3K5	STE11	STE	4bib	A	B	3-cyano-4-(piperidin-4-yloxy)-1h-indole-7-carboxamide	Human	Show
	MAP3K5	STE11	STE	4bid	A	B	5-[(1r)-2-amino-1-phenylethoxy]-2-(furan-3-yl)-3-{1h-pyrrolo[2,3-b]pyridin-3-yl}pyridine	Human	Show
	MAP3K5	STE11	STE	5v24	A	A	2-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]-n-(pyridin-2-yl)-1,3-thiazole-4-carboxamide	Human	Show
	MAP3K5	STE11	STE	5uox	B		2-(6-{4-[(2r)-1-hydroxypropan-2-yl]-4h-1,2,4-triazol-3-yl}pyridin-2-yl)-6-[(propan-2-yl)oxy]-2,3-dihydro-1h-isoindol-1-one	Human	Show
	MAP3K5	STE11	STE	2clq	B	A	staurosporine	Human	Show
	MAP3K5	STE11	STE	5up3	B		2-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-2,3-dihydro-1h-isoindol-1-one	Human	Show
	MAP3K5	STE11	STE	6e2m	A		n-[3-(4-methyl-4h-1,2,4-triazol-3-yl)phenyl]pyridine-2-carboxamide	Human	Show
	MAP3K5	STE11	STE	4bid	B	B	5-[(1r)-2-amino-1-phenylethoxy]-2-(furan-3-yl)-3-{1h-pyrrolo[2,3-b]pyridin-3-yl}pyridine	Human	Show
	MAP3K5	STE11	STE	4bf2	B		staurosporine	Human	Show
	MAP3K5	STE11	STE	4bhn	B	B	4-tert-butyl-n-[6-(1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-2-yl]benzamide	Human	Show
	MAP3K5	STE11	STE	6xih	A	A	(2r)-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}oxane-2-carboxamide	Human	Show
	MAP3K5	STE11	STE	6oyt	C		5-(4-cyclopropyl-1h-imidazol-1-yl)-2-fluoro-4-methyl-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}benzamide	Human	Show
	MAP3K5	STE11	STE	5vil	B		2-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-5-sulfamoylbenzamide	Human	Show
	MAP3K5	STE11	STE	6oyw	B	A	(19s)-19-methyl-16,17,18,19-tetrahydro-8,4-(azeno)[1,2,4]triazolo[4,3-f][1,6,13]benzoxadiazacyclohexadecin-10(9h)-one	Human	Show
	MAP3K5	STE11	STE	5vil	D		2-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-5-sulfamoylbenzamide	Human	Show
	MAP3K5	STE11	STE	2clq	B	B	staurosporine	Human	Show
	MAP3K5	STE11	STE	7mu7	A	A	3-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-1-(pyrazin-2-yl)-1h-pyrazole-4-carboxamide	Human	Show
	MAP3K5	STE11	STE	5v24	B	B	2-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]-n-(pyridin-2-yl)-1,3-thiazole-4-carboxamide	Human	Show
	MAP3K5	STE11	STE	5v19	B		n-(1-ethyl-1h-pyrazol-4-yl)furan-3-carboxamide	Human	Show
	MAP3K5	STE11	STE	6vre	A	A	3-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-1-(pyrazin-2-yl)-1h-pyrazole-4-carboxamide	Human	Show
	MAP3K5	STE11	STE	4bic	A		n-(2-aminoethyl)-5-{1h-pyrrolo[2,3-b]pyridin-3-yl}thiophene-2-sulfonamide	Human	Show
	MAP3K5	STE11	STE	5vil	C		2-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-5-sulfamoylbenzamide	Human	Show
	MAP3K5	STE11	STE	6e2m	B		n-[3-(4-methyl-4h-1,2,4-triazol-3-yl)phenyl]pyridine-2-carboxamide	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam