PDB-code
Search results (69 entries covering 26 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | File |
|---|---|---|---|---|---|---|---|---|---|---|
 | MAP4K1 (HPK1) | STE20 | STE | 7l24 | D | A | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-pyrazolo[4,3-c]pyridine | Human | Show |  |
| MAP4K1 (HPK1) | STE20 | STE | 8fh4 | A | A | (3p)-3-[6-chloro-4-(9-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 8fh4 | A | B | (3p)-3-[6-chloro-4-(9-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 8pau | A | [(5~{r})-2-[[3,5-bis(fluoranyl)-4-[[3-(trifluoromethyl)-1~{h}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]amino]-5-fluoranyl-4,6-dihydro-1,3-oxazin-5-yl]methanol | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0l | B | 4-(2-bromoanilino)-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0m | B | A | 4-[2-fluoro-6-(trifluoromethyl)anilino]-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 6cqe | A | A | - | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7r9p | A | 6-amino-2-fluoro-n,n-dimethyl-3-(4'-methylspiro[cyclopropane-1,3'-pyrrolo[2,3-b]pyridin]-5'-yl)benzamide | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0l | D | 4-(2-bromoanilino)-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 7r9n | A | B | n-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3r)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1h-pyrazolo[4,3-c]pyridin-6-amine | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0m | A | A | 4-[2-fluoro-6-(trifluoromethyl)anilino]-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7kac | B | 5-{[4-{[(1s)-2-hydroxy-1-phenylethyl]amino}-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl]amino}-3,3-dimethyl-2-benzofuran-1(3h)-one | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 6cqd | B | phosphoaminophosphonic acid-adenylate ester | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | B | B | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 6cqf | A | n-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3r)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1h-pyrazolo[4,3-c]pyridin-6-amine | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 7l26 | B | B | 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-5-carbonitrile | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7l24 | A | A | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-pyrazolo[4,3-c]pyridine | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | D | B | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 6cqe | B | B | - | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0m | B | B | 4-[2-fluoro-6-(trifluoromethyl)anilino]-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7siu | A | 6-[(5r)-5-benzamidocyclohex-1-en-1-yl]-3-[(1-methyl-1h-pyrazol-4-yl)amino]pyrazine-2-carboxamide | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 7l24 | C | B | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-pyrazolo[4,3-c]pyridine | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | C | A | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 6ng0 | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 6cqe | B | A | - | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 8cdw | A | B | ~{n}-[4-(1-methylpiperidin-4-yl)phenyl]-7-(1-methylpyrazol-4-yl)quinazolin-2-amine | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 6nfz | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | C | B | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7l24 | A | B | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-pyrazolo[4,3-c]pyridine | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0l | A | 4-(2-bromoanilino)-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 7l26 | C | A | 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-5-carbonitrile | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7l26 | C | B | 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-5-carbonitrile | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7l24 | D | B | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-pyrazolo[4,3-c]pyridine | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7l24 | B | A | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-pyrazolo[4,3-c]pyridine | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7l24 | C | A | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-pyrazolo[4,3-c]pyridine | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 6nfy | B | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7kac | A | 5-{[4-{[(1s)-2-hydroxy-1-phenylethyl]amino}-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl]amino}-3,3-dimethyl-2-benzofuran-1(3h)-one | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 6cqe | A | B | - | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 6nfy | A | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | B | A | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7l25 | A | B | 6-(2-fluoro-6-methoxyphenyl)-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-1h-pyrazolo[4,3-c]pyridine | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7r9n | A | A | n-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3r)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1h-pyrazolo[4,3-c]pyridin-6-amine | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0m | A | B | 4-[2-fluoro-6-(trifluoromethyl)anilino]-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 8fko | A | (3p)-3-{4-[(2s,5r)-5-amino-2-methylpiperidin-1-yl]-6-chloro-7h-pyrrolo[2,3-d]pyrimidin-5-yl}benzonitrile | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 6nfz | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 6nfy | B | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7l25 | B | B | 6-(2-fluoro-6-methoxyphenyl)-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-1h-pyrazolo[4,3-c]pyridine | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 8cij | A | 2-[[8-azanyl-7-fluoranyl-6-(8-methyl-2,3-dihydro-1~{h}-pyrido[2,3-b][1,4]oxazin-7-yl)isoquinolin-3-yl]amino]-6-propan-2-yl-5,8-dihydro-4~{h}-pyrazolo[1,5-d][1,4]diazepin-7-one | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 8pas | A | 4-[2,6-bis(fluoranyl)-4-(3-morpholin-4-ylpropylcarbamoylamino)phenoxy]-~{n}-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]-1~{h}-pyrrolo[2,3-b]pyridine-3-carboxamide | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 6ng0 | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 7l24 | B | B | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-pyrazolo[4,3-c]pyridine | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | D | A | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7l26 | A | A | 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-5-carbonitrile | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | A | A | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7l25 | A | A | 6-(2-fluoro-6-methoxyphenyl)-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-1h-pyrazolo[4,3-c]pyridine | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7l26 | A | B | 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-5-carbonitrile | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7l26 | B | A | 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-5-carbonitrile | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | A | B | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7l26 | D | A | 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-5-carbonitrile | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 8par | A | ~{n}-[3,5-bis(fluoranyl)-4-[[3-[1-(trifluoromethyl)cyclopropyl]-1~{h}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]-2,9-dioxa-4-azaspiro[5.5]undec-3-en-3-amine | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 7r9l | A | 2-amino-n,n-dimethyl-5-(1h-pyrrolo[2,3-b]pyridin-5-yl)benzamide | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 7l26 | D | B | 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-5-carbonitrile | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 6nfy | A | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 8fjz | A | (3p)-3-{4-[(3r,5s)-3-amino-5-methylpiperidin-1-yl]-6-chloro-7h-pyrrolo[2,3-d]pyrimidin-5-yl}benzonitrile | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 8cdw | A | A | ~{n}-[4-(1-methylpiperidin-4-yl)phenyl]-7-(1-methylpyrazol-4-yl)quinazolin-2-amine | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 7l25 | B | A | 6-(2-fluoro-6-methoxyphenyl)-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-1h-pyrazolo[4,3-c]pyridine | Human | Show | |
| MAP4K1 (HPK1) | STE20 | STE | 6cqd | A | phosphoaminophosphonic acid-adenylate ester | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 7r9t | A | 6-amino-3-[(1s,3r)-4'-chloro-3-hydroxy-1',2'-dihydrospiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-5'-yl]-2-fluoro-n,n-dimethylbenzamide | Human | Show | | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0l | C | 4-(2-bromoanilino)-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | Show | |
