Search results (93 entries covering 63 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	ALK	ALK	TK	4cli	A		(10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile	Human	Show
	ALK	ALK	TK	4cnh	B		3-[(1r)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(1-methyl-1h-1,2,3-triazol-5-yl)pyridin-2-amine	Human	Show
	ALK	ALK	TK	7r7r	A		(2r)-2-[5-(6-amino-5-{(1r)-1-[2-(1,3-dihydro-2h-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}pyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol	Human	Show
	ALK	ALK	TK	3lct	A	B	adenosine-5'-diphosphate	Human	Show
	ALK	ALK	TK	6edl	A	A	n-[(1s)-1-(2,4-difluorophenyl)ethyl]-3-(5-methyl-1h-pyrazol-3-yl)imidazo[1,2-b]pyridazin-6-amine	Human	Show
	ALK	ALK	TK	2yjr	A	B	-	Human	Show
	ALK	ALK	TK	3aox	A	A	9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5h-benzo[b]carbazole-3-carbonitrile	Human	Show
	ALK	ALK	TK	5a9u	A	A	(10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile	Human	Show
	ALK	ALK	TK	2yhv	A		-	Human	Show
	ALK	ALK	TK	5iug	A	A	n-[3-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}-3-methylphenyl)-1h-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide	Human	Show
	ALK	ALK	TK	4fnx	A		-	Human	Show
	ALK	ALK	TK	7jyr	A	B	4-{[(1r,2r)-2-(2,4-difluorophenyl)cyclopropyl]oxy}-3-(5-methyl-1h-pyrazol-3-yl)benzonitrile	Human	Show
	ALK	ALK	TK	5aac	A	B	3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine	Human	Show
	ALK	ALK	TK	5a9u	A	B	(10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile	Human	Show
	ALK	ALK	TK	4cd0	A		(2r)-2-[5-(6-amino-5-{(1r)-1-[2-(1,3-dihydro-2h-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}pyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol	Human	Show
	ALK	ALK	TK	5aa9	A	B	(10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile	Human	Show
	ALK	ALK	TK	5aa9	A	A	(10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile	Human	Show
	ALK	ALK	TK	5iui	A	B	n-[3-(4-amino-3-methylphenyl)-1h-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide	Human	Show
	ALK	ALK	TK	6cdt	A		-	Human	Show
	ALK	ALK	TK	7btt	A	B	2-(dimethylamino)-1-[5-methoxy-6-[[4-[(2-propan-2-ylsulfonylphenyl)amino]-5h-pyrrolo[3,2-d]pyrimidin-2-yl]amino]-2,3-dihydroindol-1-yl]ethanone	Human	Show
	ALK	ALK	TK	7jyt	A	A	3-(3-methyl-1h-pyrazol-5-yl)pyridine	Human	Show
	ALK	ALK	TK	6mx8	A	B	5-chloro-n~4~-[2-(dimethylphosphoryl)phenyl]-n~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine	Human	Show
	ALK	ALK	TK	2yjs	A		-	Human	Show
	ALK	ALK	TK	4dce	A		(3s)-n-(4-methylbenzyl)-1-{2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}piperidine-3-carboxamide	Human	Show
	ALK	ALK	TK	5aac	A	A	3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine	Human	Show
	ALK	ALK	TK	3lct	A	A	adenosine-5'-diphosphate	Human	Show
	ALK	ALK	TK	4cnh	A		3-[(1r)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(1-methyl-1h-1,2,3-triazol-5-yl)pyridin-2-amine	Human	Show
	ALK	ALK	TK	5iui	A	A	n-[3-(4-amino-3-methylphenyl)-1h-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide	Human	Show
	ALK	ALK	TK	7jys	A	B	3-(3-chlorophenyl)-5-methyl-1h-pyrazole	Human	Show
	ALK	ALK	TK	5fto	A	B	entrectinib	Human	Show
	ALK	ALK	TK	4ctb	A		(5r)-8-amino-3-fluoro-5,19-dimethyl-20-oxo-5,18,19,20-tetrahydro-11,7-(azeno)pyrido[2',1':2,3]imidazo[4,5-h][2,5,11]benzoxadiazacyclotetradecine-14-carbonitrile	Human	Show
	ALK	ALK	TK	2yfx	A		3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine	Human	Show
	ALK	ALK	TK	5aaa	A	A	3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine	Human	Show
	ALK	ALK	TK	5ftq	A	A	n-[5-(3,5-difluorobenzyl)-1h-indazol-3-yl]-2-[(4-hydroxycyclohexyl)amino]-4-(4-methylpiperazin-1-yl) benzamide	Human	Show
	ALK	ALK	TK	4anl	A		-	Human	Show
	ALK	ALK	TK	7jy4	A		1-{(1s,2s)-1-(2,4-difluorophenyl)-2-[2-(3-methyl-1h-pyrazol-5-yl)-4-(trifluoromethyl)phenoxy]cyclopropyl}methanamine	Human	Show
	ALK	ALK	TK	4fnz	A		(3s)-n-[3-(trifluoromethoxy)benzyl]-1-{2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}piperidine-3-carboxamide	Human	Show
	ALK	ALK	TK	5aaa	A	B	3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine	Human	Show
	ALK	ALK	TK	4cmt	A		3-{(1r)-1-[2-(1,3-dihydro-2h-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}-5-[3-(methylsulfonyl)phenyl]pyridin-2-amine	Human	Show
	ALK	ALK	TK	5aab	A	B	3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine	Human	Show
	ALK	ALK	TK	4fnw	A		-	Human	Show
	ALK	ALK	TK	5fto	A	A	entrectinib	Human	Show
	ALK	ALK	TK	4ctc	A		(10r)-7-amino-3-cyclopropyl-12-fluoro-1,10,16-trimethyl-16,17-dihydro-1h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10h)-one	Human	Show
	ALK	ALK	TK	3l9p	A	B	-	Human	Show
	ALK	ALK	TK	4mkc	A	A	5-chloro-n~2~-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-n~4~-[2-(propan-2-ylsulfonyl)phenyl]pyrimidine-2,4-diamine	Human	Show
	ALK	ALK	TK	4cmo	A		2-[(1r)-1-{[3-amino-6-(2-methoxypyridin-3-yl)pyrazin-2-yl]oxy}ethyl]-4-fluoro-n-methylbenzamide	Human	Show
	ALK	ALK	TK	2xp2	A		3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine	Human	Show
	ALK	ALK	TK	4fob	A		n-{1-[cis-4-(hydroxymethyl)cyclohexyl]-5-(piperidin-1-ylmethyl)-1h-benzimidazol-2-yl}-3-(prop-2-en-1-ylsulfamoyl)benzamide	Human	Show
	ALK	ALK	TK	2xba	A		5-[(2r)-2-hydroxy-2-phenylacetyl]-3-({[4-(4-methylpiperazin-1-yl)phenyl]carbonyl}amino)-1,6-dihydropyrrolo[3,4-c]pyrazol-5-ium	Human	Show
	ALK	ALK	TK	4foc	A		methyl cis-4-[2-(benzoylamino)-6-(piperidin-1-ylmethyl)-1h-benzimidazol-1-yl]cyclohexanecarboxylate	Human	Show
	ALK	ALK	TK	6mx8	A	A	5-chloro-n~4~-[2-(dimethylphosphoryl)phenyl]-n~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine	Human	Show
	ALK	ALK	TK	6e0r	A	A	n-[(1s)-1-(5-fluoropyridin-2-yl)ethyl]-1-(5-methyl-1h-pyrazol-3-yl)-3-[(oxetan-3-yl)sulfonyl]-1h-pyrrolo[2,3-b]pyridin-6-amine	Human	Show
	ALK	ALK	TK	7btt	A	A	2-(dimethylamino)-1-[5-methoxy-6-[[4-[(2-propan-2-ylsulfonylphenyl)amino]-5h-pyrrolo[3,2-d]pyrimidin-2-yl]amino]-2,3-dihydroindol-1-yl]ethanone	Human	Show
	ALK	ALK	TK	5aa8	A	B	(10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile	Human	Show
	ALK	ALK	TK	2xb7	A		5-chloro-n-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-n'-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine	Human	Show
	ALK	ALK	TK	4z55	A	B	n~6~-[5-methyl-4-(1-methylpiperidin-4-yl)-2-(propan-2-yloxy)phenyl]-n~4~-[2-(propan-2-ylsulfonyl)phenyl]-2h-pyrazolo[3,4-d]pyrimidine-4,6-diamine	Human	Show
	ALK	ALK	TK	5aa8	A	A	(10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile	Human	Show
	ALK	ALK	TK	7jyt	A	B	3-(3-methyl-1h-pyrazol-5-yl)pyridine	Human	Show
	ALK	ALK	TK	3lcs	A	A	staurosporine	Human	Show
	ALK	ALK	TK	7jyr	A	A	4-{[(1r,2r)-2-(2,4-difluorophenyl)cyclopropyl]oxy}-3-(5-methyl-1h-pyrazol-3-yl)benzonitrile	Human	Show
	ALK	ALK	TK	4z55	A	A	n~6~-[5-methyl-4-(1-methylpiperidin-4-yl)-2-(propan-2-yloxy)phenyl]-n~4~-[2-(propan-2-ylsulfonyl)phenyl]-2h-pyrazolo[3,4-d]pyrimidine-4,6-diamine	Human	Show
	ALK	ALK	TK	4ccu	A		2-(5-(6-amino-5-((r)-1-(5-fluoro-2-(2h-1,2,3-triazol-2-yl)phenyl)ethoxy)pyridin-3-yl)-4-methylthiazol-2-yl)propan-2-ol	Human	Show
	ALK	ALK	TK	8arj	A	A	3-(dimethylamino)-1-[3-[4-(4-methylpiperazin-1-yl)phenyl]-9~{h}-pyrido[2,3-b]indol-6-yl]prop-2-en-1-one	Human	Show
	ALK	ALK	TK	3aox	A	B	9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5h-benzo[b]carbazole-3-carbonitrile	Human	Show
	ALK	ALK	TK	5iug	A	B	n-[3-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}-3-methylphenyl)-1h-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide	Human	Show
	ALK	ALK	TK	4mkc	A	B	5-chloro-n~2~-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-n~4~-[2-(propan-2-ylsulfonyl)phenyl]pyrimidine-2,4-diamine	Human	Show
	ALK	ALK	TK	4dce	B		(3s)-n-(4-methylbenzyl)-1-{2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}piperidine-3-carboxamide	Human	Show
	ALK	ALK	TK	4fny	A		n-(4-chlorophenyl)-5-[(6,7-dimethoxyquinolin-4-yl)oxy]-1,3-benzoxazol-2-amine	Human	Show
	ALK	ALK	TK	4tt7	A	A	-	Human	Show
	ALK	ALK	TK	4tt7	A	B	-	Human	Show
	ALK	ALK	TK	4fod	A	B	4-fluoro-n-{(2e)-6-{[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl}-1-[cis-4-(propan-2-ylcarbamoyl)cyclohexyl]-1,3-dihydro-2h-benzimidazol-2-ylidene}benzamide	Human	Show
	ALK	ALK	TK	2yjr	A	A	-	Human	Show
	ALK	ALK	TK	4clj	A		(10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile	Human	Show
	ALK	ALK	TK	5iuh	A		4-[(4-methylpiperazin-1-yl)methyl]-n-{3-[3-methyl-4-({[5-(propan-2-yl)-1,2-oxazol-3-yl]carbamoyl}amino)phenyl]-1h-pyrazol-5-yl}benzamide	Human	Show
	ALK	ALK	TK	5ftq	A	B	n-[5-(3,5-difluorobenzyl)-1h-indazol-3-yl]-2-[(4-hydroxycyclohexyl)amino]-4-(4-methylpiperazin-1-yl) benzamide	Human	Show
	ALK	ALK	TK	4fod	A	A	4-fluoro-n-{(2e)-6-{[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl}-1-[cis-4-(propan-2-ylcarbamoyl)cyclohexyl]-1,3-dihydro-2h-benzimidazol-2-ylidene}benzamide	Human	Show
	ALK	ALK	TK	8arj	A	B	3-(dimethylamino)-1-[3-[4-(4-methylpiperazin-1-yl)phenyl]-9~{h}-pyrido[2,3-b]indol-6-yl]prop-2-en-1-one	Human	Show
	ALK	ALK	TK	4joa	A	A	3-[1-(2,5-difluorobenzyl)-1h-pyrazol-4-yl]-5-(1-methyl-1h-pyrazol-4-yl)-1h-pyrrolo[2,3-b]pyridine	Human	Show
	ALK	ALK	TK	6edl	A	B	n-[(1s)-1-(2,4-difluorophenyl)ethyl]-3-(5-methyl-1h-pyrazol-3-yl)imidazo[1,2-b]pyridazin-6-amine	Human	Show
	ALK	ALK	TK	4cmu	A		(10r)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro-1h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10h)-one	Human	Show
	ALK	ALK	TK	5kz0	A		2-[(1~{r})-1-[2-azanyl-5-(1,3-dimethylpyrazol-4-yl)pyridin-3-yl]oxyethyl]-4-fluoranyl-~{n},~{n}-dimethyl-benzamide	Human	Show
	ALK	ALK	TK	5aab	A	A	3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine	Human	Show
	ALK	ALK	TK	4anq	A		3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine	Human	Show
	ALK	ALK	TK	6e0r	A	B	n-[(1s)-1-(5-fluoropyridin-2-yl)ethyl]-1-(5-methyl-1h-pyrazol-3-yl)-3-[(oxetan-3-yl)sulfonyl]-1h-pyrrolo[2,3-b]pyridin-6-amine	Human	Show
	ALK	ALK	TK	7jys	A	A	3-(3-chlorophenyl)-5-methyl-1h-pyrazole	Human	Show
	ALK	ALK	TK	6ebw	A	A	[6-{[(1s)-1-(5-fluoropyridin-2-yl)ethyl]amino}-1-(5-methyl-1h-pyrazol-3-yl)-1h-pyrrolo[2,3-b]pyridin-3-yl](morpholin-4-yl)methanone	Human	Show
	ALK	ALK	TK	6ebw	A	B	[6-{[(1s)-1-(5-fluoropyridin-2-yl)ethyl]amino}-1-(5-methyl-1h-pyrazol-3-yl)-1h-pyrrolo[2,3-b]pyridin-3-yl](morpholin-4-yl)methanone	Human	Show
	ALK	ALK	TK	4ccb	A		3-[(1r)-1-[5-fluoranyl-2-(1,2,3-triazol-2-yl)phenyl]ethoxy]-5-(3-methyl-1h-pyrazol-4-yl)pyridin-2-amine	Human	Show
	ALK	ALK	TK	3l9p	A	A	-	Human	Show
	ALK	ALK	TK	3lcs	A	B	staurosporine	Human	Show
	ALK	ALK	TK	5imx	A		5-chloro-n~2~-{5-methyl-4-(1-methylpiperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-n~4~-{1-methyl-3-[(propan-2-yl)sulfonyl]-1h-pyrazol-4-yl}pyrimidine-2,4-diamine	Human	Show
	ALK	ALK	TK	7r7k	A		4-(6-amino-5-{(1r)-1-[5-fluoro-2-(2h-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-3-yl)-2,3-dihydro-1h-isoindol-1-one	Human	Show
	ALK	ALK	TK	4ans	A		3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam