PDB-code
Search results (79 entries covering 35 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | File |
|---|---|---|---|---|---|---|---|---|---|---|
 | MERTK (MER) | Axl | TK | 3bpr | B | B | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | Human | Show |  |
| MERTK (MER) | Axl | TK | 5u6c | A | A | (10r)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3,10,16-trimethyl-16,17-dihydro-1h-8,4-(azeno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10h)-one | Human | Show | |
| MERTK (MER) | Axl | TK | 5k0x | B | B | (7s)-7-amino-n-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 7dxl | A | 3-[4-[6-chloranyl-5-[[(3r)-pyrrolidin-3-yl]amino]-1h-indazol-3-yl]pyrazol-1-yl]benzenecarbonitrile | Human | Show | | |
| MERTK (MER) | Axl | TK | 7m5z | A | A | 2-(butylamino)-n-[1-(3-fluoropropyl)piperidin-4-yl]-4-{[(1r,4r)-4-hydroxycyclohexyl]amino}pyrimidine-5-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 7aaz | A | A | 2-azanyl-~{n}-[(1~{s},2~{s})-2-[[4-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]phenyl]methoxy]cyclopentyl]-5-(1-methylpyrazol-4-yl)pyridine-3-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 3bpr | D | A | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | Human | Show | |
| MERTK (MER) | Axl | TK | 5k0x | A | B | (7s)-7-amino-n-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 7aw3 | A | 2-(1-((5-chloro-1h-pyrrolo[2,3-b]pyridine-3-carboxamido)methyl)-2-azabicyclo[2.1.1]hexan-2-yl)-n-methyl-4-(trifluoromethyl)thiazole-5-carboxamide | Human | Show | | |
| MERTK (MER) | Axl | TK | 3bpr | D | B | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | Human | Show | |
| MERTK (MER) | Axl | TK | 5tc0 | A | n-(2-{4-[(2s)-4-(methylsulfonyl)morpholin-2-yl]-1,3-thiazol-2-yl}phenyl)-1h-imidazole-2-carboxamide | Human | Show | | |
| MERTK (MER) | Axl | TK | 7olx | A | ~{n}-[[3-[4-[(dimethylamino)methyl]phenyl]imidazo[1,2-a]pyridin-6-yl]methyl]-~{n}-methyl-5-[3-methyl-5-(1,3,5-trimethylpyrazol-4-yl)pyridin-2-yl]-1,3,4-oxadiazol-2-amine | Human | Show | | |
| MERTK (MER) | Axl | TK | 7ab2 | A | A | 4-[2-(butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol | Human | Show | |
| MERTK (MER) | Axl | TK | 7cqe | A | 5-(3-fluorophenyl)-n-[(3s)-3-piperidyl]-3-ureido-thiophene-2-carboxamide | Human | Show | | |
| MERTK (MER) | Axl | TK | 5k0k | B | B | 15-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4,5,6,7,9,10,11,12-octahydro-2,16-(azenometheno)pyrrolo[2,1-d][1,3,5,9]tetraazacyclotetradecin-8(3h)-one | Human | Show | |
| MERTK (MER) | Axl | TK | 5k0k | A | B | 15-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4,5,6,7,9,10,11,12-octahydro-2,16-(azenometheno)pyrrolo[2,1-d][1,3,5,9]tetraazacyclotetradecin-8(3h)-one | Human | Show | |
| MERTK (MER) | Axl | TK | 4mha | A | A | 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-n-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 5td2 | A | B | n-[2-{4-[(2s)-4-(methylsulfonyl)morpholin-2-yl]-1,3-thiazol-2-yl}-4-(morpholin-4-yl)phenyl]-1h-imidazole-2-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 4mha | A | B | 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-n-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 7m5z | A | B | 2-(butylamino)-n-[1-(3-fluoropropyl)piperidin-4-yl]-4-{[(1r,4r)-4-hydroxycyclohexyl]amino}pyrimidine-5-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 3bpr | C | B | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | Human | Show | |
| MERTK (MER) | Axl | TK | 4mha | B | A | 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-n-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 4mh7 | A | n-butyl-2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-n-methylpyrimidine-5-carboxamide | Human | Show | | |
| MERTK (MER) | Axl | TK | 3brb | A | A | adenosine-5'-diphosphate | Human | Show | |
| MERTK (MER) | Axl | TK | 2p0c | B | B | phosphoaminophosphonic acid-adenylate ester | Human | Show | |
| MERTK (MER) | Axl | TK | 5k0k | A | A | 15-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4,5,6,7,9,10,11,12-octahydro-2,16-(azenometheno)pyrrolo[2,1-d][1,3,5,9]tetraazacyclotetradecin-8(3h)-one | Human | Show | |
| MERTK (MER) | Axl | TK | 2p0c | A | B | phosphoaminophosphonic acid-adenylate ester | Human | Show | |
| MERTK (MER) | Axl | TK | 4mh7 | B | - | Human | Show | | |
| MERTK (MER) | Axl | TK | 7avy | A | n-(2-(2-cyclopropylethoxy)pyrimidin-5-yl)-7-methoxy-6-(piperidin-4-ylmethoxy)quinazolin-4-amine | Human | Show | | |
| MERTK (MER) | Axl | TK | 3brb | B | B | adenosine-5'-diphosphate | Human | Show | |
| MERTK (MER) | Axl | TK | 3brb | A | B | adenosine-5'-diphosphate | Human | Show | |
| MERTK (MER) | Axl | TK | 5k0x | A | A | (7s)-7-amino-n-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 6mep | A | cis-4-[(2-[(4-{[4-(1,3-dioxolan-2-yl)pyridin-2-yl]ethynyl}phenyl)amino]-5-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}pyrimidin-4-yl)amino]cyclohexan-1-ol | Human | Show | | |
| MERTK (MER) | Axl | TK | 3bpr | A | A | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | Human | Show | |
| MERTK (MER) | Axl | TK | 5td2 | A | A | n-[2-{4-[(2s)-4-(methylsulfonyl)morpholin-2-yl]-1,3-thiazol-2-yl}-4-(morpholin-4-yl)phenyl]-1h-imidazole-2-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 4m3q | A | trans-4-{[2-(butylamino)-5-(pyridin-2-yl)pyrimidin-4-yl]amino}cyclohexanol | Human | Show | | |
| MERTK (MER) | Axl | TK | 7aw4 | A | A | 3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)-n-((r)-1-(((r)-3-(methylamino)-3-oxo-1-(4-(trifluoromethyl)phenyl)propyl)amino)-1-oxo-4-phenylbutan-2-yl)isoxazole-4-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 7avz | A | (r)-n2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-5-(3-methylpiperazin-1-yl)-n4-(tetrahydro-2h-pyran-4-yl)pyrimidine-2,4-diamine | Human | Show | | |
| MERTK (MER) | Axl | TK | 2p0c | A | A | phosphoaminophosphonic acid-adenylate ester | Human | Show | |
| MERTK (MER) | Axl | TK | 7aw4 | A | B | 3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)-n-((r)-1-(((r)-3-(methylamino)-3-oxo-1-(4-(trifluoromethyl)phenyl)propyl)amino)-1-oxo-4-phenylbutan-2-yl)isoxazole-4-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 7avx | A | 1-(4-fluorophenyl)-n-[3-fluoro-4-[(3-phenyl-1h-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dimethyl-5-oxopyrazole-4-carboxamide | Human | Show | | |
| MERTK (MER) | Axl | TK | 2p0c | B | A | phosphoaminophosphonic acid-adenylate ester | Human | Show | |
| MERTK (MER) | Axl | TK | 4mha | B | B | 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-n-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 3bpr | C | A | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | Human | Show | |
| MERTK (MER) | Axl | TK | 5td2 | B | A | - | Human | Show | |
| MERTK (MER) | Axl | TK | 7aw0 | A | 2-(cyclopentyloxy)-9-(2,6-difluorobenzyl)-n-methyl-9h-purin-6-amine | Human | Show | | |
| MERTK (MER) | Axl | TK | 5u6c | B | B | (10r)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3,10,16-trimethyl-16,17-dihydro-1h-8,4-(azeno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10h)-one | Human | Show | |
| MERTK (MER) | Axl | TK | 7cqe | C | 5-(3-fluorophenyl)-n-[(3s)-3-piperidyl]-3-ureido-thiophene-2-carboxamide | Human | Show | | |
| MERTK (MER) | Axl | TK | 7oam | A | - | Human | Show | | |
| MERTK (MER) | Axl | TK | 7aax | A | A | ~{n}-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluoranyl-phenyl]-4-ethoxy-1-(4-fluoranyl-2-methyl-phenyl)pyrazole-3-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 7ab0 | A | B | - | Human | Show | |
| MERTK (MER) | Axl | TK | 7aw2 | A | 5-(2'-chloro-[1,1'-biphenyl]-4-yl)-n-(imidazo[1,2-a]pyridin-6-ylmethyl)-n-methyl-1,3,4-oxadiazol-2-amine | Human | Show | | |
| MERTK (MER) | Axl | TK | 5td2 | B | B | - | Human | Show | |
| MERTK (MER) | Axl | TK | 7aay | A | A | n-(3-fluoro-4-{[1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 7aw4 | B | A | 3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)-n-((r)-1-(((r)-3-(methylamino)-3-oxo-1-(4-(trifluoromethyl)phenyl)propyl)amino)-1-oxo-4-phenylbutan-2-yl)isoxazole-4-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 7aax | A | B | ~{n}-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluoranyl-phenyl]-4-ethoxy-1-(4-fluoranyl-2-methyl-phenyl)pyrazole-3-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 5k0x | B | A | (7s)-7-amino-n-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 7olv | A | 4-[4-[5-[imidazo[1,2-a]pyridin-6-ylmethyl(methyl)amino]-1,3,4-oxadiazol-2-yl]-3-methyl-phenyl]-2,5-dimethyl-pyrazole-3-carbonitrile | Human | Show | | |
| MERTK (MER) | Axl | TK | 4m3q | B | trans-4-{[2-(butylamino)-5-(pyridin-2-yl)pyrimidin-4-yl]amino}cyclohexanol | Human | Show | | |
| MERTK (MER) | Axl | TK | 5tc0 | B | - | Human | Show | | |
| MERTK (MER) | Axl | TK | 7ab1 | A | 6-ethyl-3-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide | Human | Show | | |
| MERTK (MER) | Axl | TK | 7aw1 | A | n-(6-(4-(3-(4-((5,6-dihydroimidazo[1,2-a]pyrazin-7(8h)-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide | Human | Show | | |
| MERTK (MER) | Axl | TK | 7ab0 | A | A | - | Human | Show | |
| MERTK (MER) | Axl | TK | 7aaz | A | B | 2-azanyl-~{n}-[(1~{s},2~{s})-2-[[4-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]phenyl]methoxy]cyclopentyl]-5-(1-methylpyrazol-4-yl)pyridine-3-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 5k0k | B | A | 15-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4,5,6,7,9,10,11,12-octahydro-2,16-(azenometheno)pyrrolo[2,1-d][1,3,5,9]tetraazacyclotetradecin-8(3h)-one | Human | Show | |
| MERTK (MER) | Axl | TK | 7aw4 | B | B | 3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)-n-((r)-1-(((r)-3-(methylamino)-3-oxo-1-(4-(trifluoromethyl)phenyl)propyl)amino)-1-oxo-4-phenylbutan-2-yl)isoxazole-4-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 7xhy | A | ~{n}-[4-(2-azanyl-3-chloranyl-pyridin-4-yl)oxy-3-fluoranyl-phenyl]-5-(4-fluorophenyl)-4-oxidanylidene-1~{h}-pyridine-3-carboxamide | Human | Show | | |
| MERTK (MER) | Axl | TK | 7aay | A | B | n-(3-fluoro-4-{[1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide | Human | Show | |
| MERTK (MER) | Axl | TK | 7ab2 | A | B | 4-[2-(butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol | Human | Show | |
| MERTK (MER) | Axl | TK | 3bpr | B | A | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | Human | Show | |
| MERTK (MER) | Axl | TK | 3brb | B | A | adenosine-5'-diphosphate | Human | Show | |
| MERTK (MER) | Axl | TK | 5u6c | A | B | (10r)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3,10,16-trimethyl-16,17-dihydro-1h-8,4-(azeno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10h)-one | Human | Show | |
| MERTK (MER) | Axl | TK | 3tcp | B | 1-[(trans-4-aminocyclohexyl)methyl]-n-butyl-3-(4-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidin-6-amine | Human | Show | | |
| MERTK (MER) | Axl | TK | 7avx | B | 1-(4-fluorophenyl)-n-[3-fluoro-4-[(3-phenyl-1h-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dimethyl-5-oxopyrazole-4-carboxamide | Human | Show | | |
| MERTK (MER) | Axl | TK | 5u6c | B | A | (10r)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3,10,16-trimethyl-16,17-dihydro-1h-8,4-(azeno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10h)-one | Human | Show | |
| MERTK (MER) | Axl | TK | 3tcp | A | 1-[(trans-4-aminocyclohexyl)methyl]-n-butyl-3-(4-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidin-6-amine | Human | Show | | |
| MERTK (MER) | Axl | TK | 7ols | A | 5-[4-(1,5-dimethylpyrazol-4-yl)-2-methyl-phenyl]-~{n}-(imidazo[1,2-a]pyridin-6-ylmethyl)-~{n}-methyl-1,3,4-oxadiazol-2-amine | Human | Show | | |
| MERTK (MER) | Axl | TK | 6mep | B | cis-4-[(2-[(4-{[4-(1,3-dioxolan-2-yl)pyridin-2-yl]ethynyl}phenyl)amino]-5-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}pyrimidin-4-yl)amino]cyclohexan-1-ol | Human | Show | | |
| MERTK (MER) | Axl | TK | 3bpr | A | B | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | Human | Show | |
