Search results (49 entries covering 25 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	HCK	Src	TK	3vs3	B		7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	HCK	Src	TK	3vrz	A		1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea	Human	Show
	HCK	Src	TK	2hck	B		3,5,7,3',4'-pentahydroxyflavone	Human	Show
	HCK	Src	TK	5zj6	A		7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	HCK	Src	TK	1ad5	B		phosphoaminophosphonic acid-adenylate ester	Human	Show
	HCK	Src	TK	2c0t	B	A	n-(4-{4-amino-1-[1-(tetrahydro-2h-pyran-4-yl)piperidin-4-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide	Human	Show
	HCK	Src	TK	5h0g	A		(2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{n},4-dimethyl-pentanamide	Human	Show
	HCK	Src	TK	3vrz	B		1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea	Human	Show
	HCK	Src	TK	2c0i	A	A	n-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)-trans-cyclohexyl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide	Human	Show
	HCK	Src	TK	3vs0	A		n-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide	Human	Show
	HCK	Src	TK	3vs1	B		1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea	Human	Show
	HCK	Src	TK	2c0o	B	A	n-(4-{1-[4-(4-acetylpiperazin-1-yl)-trans-cyclohexyl]-4-amino-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide	Human	Show
	HCK	Src	TK	2hck	A		3,5,7,3',4'-pentahydroxyflavone	Human	Show
	HCK	Src	TK	2c0i	B	A	n-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)-trans-cyclohexyl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide	Human	Show
	HCK	Src	TK	3vs4	A		5-(4-phenoxyphenyl)-7-(tetrahydro-2h-pyran-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	HCK	Src	TK	3vs0	B		n-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide	Human	Show
	HCK	Src	TK	2c0i	B	B	n-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)-trans-cyclohexyl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide	Human	Show
	HCK	Src	TK	3vs2	B		7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	HCK	Src	TK	3vs5	B		7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	HCK	Src	TK	3vs2	A		7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	HCK	Src	TK	2c0t	A	B	n-(4-{4-amino-1-[1-(tetrahydro-2h-pyran-4-yl)piperidin-4-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide	Human	Show
	HCK	Src	TK	3vs6	B		tert-butyl {4-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate	Human	Show
	HCK	Src	TK	3vs7	A		1-cyclopentyl-3-(1h-pyrrolo[2,3-b]pyridin-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine	Human	Show
	HCK	Src	TK	3vs5	A		7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	HCK	Src	TK	1qcf	A		1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine	Human	Show
	HCK	Src	TK	3vs7	B		1-cyclopentyl-3-(1h-pyrrolo[2,3-b]pyridin-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine	Human	Show
	HCK	Src	TK	4lue	A		7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	HCK	Src	TK	2c0t	A	A	n-(4-{4-amino-1-[1-(tetrahydro-2h-pyran-4-yl)piperidin-4-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide	Human	Show
	HCK	Src	TK	2c0o	A	A	n-(4-{1-[4-(4-acetylpiperazin-1-yl)-trans-cyclohexyl]-4-amino-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide	Human	Show
	HCK	Src	TK	4lue	B		7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	HCK	Src	TK	5h09	A		ethyl (2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanoate	Human	Show
	HCK	Src	TK	5h0h	A		(2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{n},~{n},4-trimethyl-pentanamide	Human	Show
	HCK	Src	TK	2c0t	B	B	n-(4-{4-amino-1-[1-(tetrahydro-2h-pyran-4-yl)piperidin-4-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide	Human	Show
	HCK	Src	TK	2c0o	A	B	n-(4-{1-[4-(4-acetylpiperazin-1-yl)-trans-cyclohexyl]-4-amino-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide	Human	Show
	HCK	Src	TK	2hk5	A		3-{[2-(1h-benzimidazol-1-yl)-6-{[2-(diethylamino)ethyl]amino}pyrimidin-4-yl]amino}-4-methylphenol	Human	Show
	HCK	Src	TK	3vs3	A		7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	HCK	Src	TK	3vs6	A		tert-butyl {4-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate	Human	Show
	HCK	Src	TK	3vry	A		4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane	Human	Show
	HCK	Src	TK	4lud	A		6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole	Human	Show
	HCK	Src	TK	2c0i	A	B	n-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)-trans-cyclohexyl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide	Human	Show
	HCK	Src	TK	5h0e	A		(2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanamide	Human	Show
	HCK	Src	TK	4lud	B		6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole	Human	Show
	HCK	Src	TK	3vry	B		4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane	Human	Show
	HCK	Src	TK	2c0o	B	B	n-(4-{1-[4-(4-acetylpiperazin-1-yl)-trans-cyclohexyl]-4-amino-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide	Human	Show
	HCK	Src	TK	5h0b	A		(2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]azaniumyl]-4-methyl-pentanoate	Human	Show
	HCK	Src	TK	5zj6	B		7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	HCK	Src	TK	3vs4	B		5-(4-phenoxyphenyl)-7-(tetrahydro-2h-pyran-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	HCK	Src	TK	1ad5	A		phosphoaminophosphonic acid-adenylate ester	Human	Show
	HCK	Src	TK	3vs1	A		1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam