KLIFS - the kinase structures database

Version: 3.2
Updated: 29-Oct-2025

Eukaryotic translation initiation factor 2 alpha kinase 4

Kinase structure
Kinase:	EIF2AK4 (GCN2)
Family:	PEK
Group:	Other
Species:	HUMAN
IUPHAR/BPS ID:	2018
PDB:	7QQ6
sc-PDB:
KIDFamMap:	Search
Release date:	2022-03-02
PubMed:	31868900
Chain:	A
Orthosteric ligand:	38O

Structural information
DFG conformation:	in
αC-helix conformation:	in
G-rich loop angle (distance):	-
G-rich loop rotation:	-
Quality Score:	5
Resolution:	2.8 Å
Missing Residues:	20
Missing Atoms:	10

Ligand binding mode
Pockets	Subpockets
front

Pocket alignment
Uniprot sequence:	QLLGKGAFGAVIKYAVKRIRIKGEVTLLSRLHENIVRYYNALDSVEAAAPPPILSSSVEYIHEKGMIHRDLKPVNIFLIGDFGLA
Sequence structure:	QLLGKGAFGAVIKYAVKRIRIKGEVTLLSRLHENIVRYYNA__________________YIHEKGMIHRNLKPVNIFLIGDFG__

Ligand affinity
ChEMBL ID:	CHEMBL522892
Bioaffinities:	483 records for 197 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	3-phosphoinositide dependent protein kinase-1	6	6	6	pKi	1
Homo sapiens	Activin receptor type-1	5.9	5.9	5.9	pKi	1
Homo sapiens	Adaptor-associated kinase	6.8	6.8	6.8	pKd	2
Homo sapiens	ALK tyrosine kinase receptor	5.5	5.5	5.5	pKd	2
Homo sapiens	ALK tyrosine kinase receptor	6.2	6.2	6.2	pKi	1
Homo sapiens	AMP-activated protein kinase, alpha-1 subunit	6.3	6.3	6.3	pKd	2
Homo sapiens	AMP-activated protein kinase, alpha-1 subunit	7.1	7.1	7.1	pKi	1
Homo sapiens	AMP-activated protein kinase, alpha-2 subunit	6.1	6.1	6.1	pKd	2
Homo sapiens	Ankyrin repeat and protein kinase domain-containing protein 1	7.1	7.1	7.1	pKd	2
Homo sapiens	BMP-2-inducible protein kinase	7.3	7.3	7.3	pKd	2
Homo sapiens	Bone morphogenetic protein receptor type-2	5.5	5.5	5.5	pKd	2
Homo sapiens	BR serine/threonine-protein kinase 1	6.4	6.4	6.4	pKi	1
Plasmodium falciparum (isolate 3D7)	Calcium-dependent protein kinase 1	6.2	6.2	6.2	pKd	1
Homo sapiens	CaM kinase II delta	6.5	6.5	6.5	pKi	1
Homo sapiens	CaM kinase II gamma	6.1	6.1	6.1	pKi	1
Homo sapiens	CaM-kinase kinase alpha	5.5	5.5	5.5	pKd	2
Homo sapiens	CaM-kinase kinase beta	6.8	6.8	6.8	pKi	1
Homo sapiens	Casein kinase I delta	5.8	5.8	5.8	pKi	1
Homo sapiens	Casein kinase II alpha	5.6	5.6	5.9	pKd	2
Homo sapiens	Casein kinase II alpha (prime)	5.8	5.8	6.7	pKd	2
Homo sapiens	Citron Rho-interacting kinase	5.1	5.1	5.1	pKd	2
Homo sapiens	c-Jun N-terminal kinase 1	5.5	5.5	5.5	pKi	1
Homo sapiens	c-Jun N-terminal kinase 3	6.2	6.2	6.2	pKi	1
Homo sapiens	Cyclin-dependent kinase 4	5.5	5.5	5.9	pKd	2
Homo sapiens	Cyclin-dependent kinase 7	5.6	5.6	5.6	pKd	2
Homo sapiens	Cyclin-dependent kinase 7	6.6	6.6	6.6	pKi	1
Homo sapiens	Cyclin-dependent kinase-like 2	6.8	6.8	6.8	pKd	1
Homo sapiens	Death-associated protein kinase 3	5.7	5.7	5.7	pKd	1
Homo sapiens	Discoidin domain-containing receptor 2	5.1	5.1	5.1	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	6.3	6.3	6.3	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	6.9	6.9	6.9	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	6.5	6.5	6.5	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	6.8	6.8	6.8	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 5	7.5	7.5	7.5	pKd	1
Homo sapiens	Dual specificity protein kinase CLK2	5.8	5.8	5.8	pKd	2
Homo sapiens	Dual specificity protein kinase CLK2	6.1	6.1	6.1	pKi	1
Homo sapiens	Dual specificity protein kinase CLK4	5.2	5.2	5.2	pKd	2
Homo sapiens	Dual specificity protein kinase CLK4	7	7	7	pKi	1
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 2	5.2	5.2	5.2	pKd	1
Homo sapiens	Dual specificty protein kinase CLK1	5.2	5.2	5.2	pKd	2
Homo sapiens	Epidermal growth factor receptor erbB1	5.9	5.9	6	pKd	2
Homo sapiens	Epithelial discoidin domain-containing receptor 1	5.6	5.6	5.6	pKd	2
Homo sapiens	Eukaryotic translation initiation factor 2-alpha kinase 4	6.6	6.6	6.6	pKd	2
Homo sapiens	Fibroblast growth factor receptor 1	6.8	6.8	6.8	pEC50	1
Homo sapiens	Fibroblast growth factor receptor 1	8	8	8.1	pIC50	2
Homo sapiens	Fibroblast growth factor receptor 1	6.8	6.8	6.8	pKd	2
Homo sapiens	Fibroblast growth factor receptor 1	7.6	7.6	7.6	pKi	1
Homo sapiens	Fibroblast growth factor receptor 2	6.4	6.4	6.4	pKd	2
Homo sapiens	Fibroblast growth factor receptor 3	8.1	8.1	8.5	pIC50	2
Homo sapiens	Fibroblast growth factor receptor 3	6.4	6.4	6.6	pKd	4
Homo sapiens	Fibroblast growth factor receptor 3	7.4	7.4	7.4	pKi	1
Homo sapiens	Fibroblast growth factor receptor 4	5.4	5.4	5.4	pKd	2
Homo sapiens	Glycogen synthase kinase-3 beta	6.5	6.5	6.5	pKd	2
Homo sapiens	G protein-coupled receptor kinase 4	7	7	7	pKd	1
Homo sapiens	G protein-coupled receptor kinase 7	5.9	5.9	5.9	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 1	5.4	5.4	5.4	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 2	6.3	6.3	6.3	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 3	5.3	5.3	5.3	pKd	1
Homo sapiens	Hormonally up-regulated neu tumor-associated kinase	6.4	6.4	6.4	pKd	1
Homo sapiens	Inhibitor of nuclear factor kappa B kinase alpha subunit	5.8	5.8	5.8	pKd	1
Homo sapiens	Inhibitor of nuclear factor kappa B kinase epsilon subunit	6.3	6.3	6.3	pKd	2
Homo sapiens	Inhibitor of nuclear factor kappa B kinase epsilon subunit	6.1	6.1	6.1	pKi	1
Homo sapiens	Insulin receptor	5.8	5.8	5.8	pKi	1
Homo sapiens	Interferon-induced, double-stranded RNA-activated protein kinase	5.6	5.6	5.6	pKd	2
Homo sapiens	Interleukin-1 receptor-associated kinase 1	6.8	6.8	6.8	pKd	1
Homo sapiens	Interleukin-1 receptor-associated kinase 1	5.9	5.9	5.9	pKi	1
Homo sapiens	Interleukin-1 receptor-associated kinase 4	6.9	6.9	6.9	pKd	1
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	5.8	5.8	6.1	pKd	2
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	6.5	6.5	6.5	pKi	1
Homo sapiens	LIM domain kinase 1	5.7	5.7	5.7	pKi	1
Homo sapiens	Macrophage colony stimulating factor receptor	8.5	8.5	9	pIC50	2
Homo sapiens	Macrophage colony stimulating factor receptor	7.2	7.2	7.2	pKd	2
Homo sapiens	Macrophage colony stimulating factor receptor	7.4	7.4	7.4	pKi	1
Homo sapiens	Macrophage-stimulating protein receptor	7.6	7.6	7.6	pKi	1
Homo sapiens	MAP/microtubule affinity-regulating kinase 2	5.8	5.8	5.8	pKd	2
Homo sapiens	MAP/microtubule affinity-regulating kinase 2	6.9	6.9	6.9	pKi	1
Homo sapiens	MAP/microtubule affinity-regulating kinase 4	5.8	5.8	5.8	pKd	2
Homo sapiens	MAP/microtubule affinity-regulating kinase 4	7	7	7	pKi	1
Homo sapiens	Maternal embryonic leucine zipper kinase	5.8	5.8	5.8	pKd	2
Homo sapiens	Maternal embryonic leucine zipper kinase	7.5	7.5	7.5	pKi	1
Homo sapiens	Microtubule-associated serine/threonine-protein kinase 1	7.4	7.4	7.4	pKd	1
Homo sapiens	Misshapen-like kinase 1	8	8	8	pKd	1
Homo sapiens	Misshapen-like kinase 1	8	8	8	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 10	5.8	5.8	5.8	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 11	5.7	5.7	5.7	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 12	5.7	5.7	5.7	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 13	6.8	6.8	6.8	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 2	7.2	7.2	7.2	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 4	5.3	5.3	5.3	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 7	6.2	6.2	6.2	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 9	5	5	5	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 1	7.4	7.4	7.4	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	5.7	5.7	5.7	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	6.2	6.2	6.2	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 3	6.3	6.3	6.3	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 4	6.8	6.8	6.8	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 4	7.6	7.6	7.6	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	6.2	6.2	6.2	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	7.5	7.5	7.5	pKi	1
Homo sapiens	Mixed lineage kinase 7	5.1	5.1	5.1	pKi	1
Homo sapiens	Muscle, skeletal receptor tyrosine protein kinase	6.1	6.1	6.1	pKd	2
Homo sapiens	Myosin light chain kinase	8.7	8.7	8.7	pKd	1
Homo sapiens	myosin light chain kinase 2	7	7	7	pKd	2
Homo sapiens	Myosin light chain kinase family member 4	7.1	7.1	7.1	pKd	2
Gallus gallus	Myosin light chain kinase, smooth muscle	8.7	8.7	8.7	pKd	1
Homo sapiens	Myosin light chain kinase, smooth muscle	5.5	5.5	5.5	pKd	2
Homo sapiens	Nerve growth factor receptor Trk-A	7	7	7	pKd	2
Homo sapiens	Nerve growth factor receptor Trk-A	6.6	6.6	6.6	pKi	1
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	6.1	6.1	6.1	pKd	2
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	7	7	7	pKi	1
Homo sapiens	NT-3 growth factor receptor	6.7	6.7	6.7	pKd	2
Homo sapiens	NT-3 growth factor receptor	6.7	6.7	6.7	pKi	1
Homo sapiens	NUAK family SNF1-like kinase 1	6.6	6.6	6.6	pKd	2
Homo sapiens	NUAK family SNF1-like kinase 2	6.9	6.9	6.9	pKd	2
Homo sapiens	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha	5.7	5.7	5.7	pKd	2
Homo sapiens	Phosphatidylinositol-5-phosphate 4-kinase type-2 beta	6.6	6.6	6.6	pKd	2
Homo sapiens	Phosphorylase kinase gamma subunit 1	6.2	6.2	6.2	pKd	2
Homo sapiens	Phosphorylase kinase gamma subunit 2	5.1	5.1	5.1	pKd	2
Homo sapiens	Phosphorylase kinase gamma subunit 2	6	6	6	pKi	1
Homo sapiens	Platelet-derived growth factor receptor alpha	7.3	7.3	7.3	pKd	2
Homo sapiens	Platelet-derived growth factor receptor alpha	6.6	6.6	6.6	pKi	1
Homo sapiens	Platelet-derived growth factor receptor beta	7.3	7.3	7.3	pEC50	1
Homo sapiens	Platelet-derived growth factor receptor beta	8.3	8.3	9	pIC50	2
Homo sapiens	Platelet-derived growth factor receptor beta	8.4	8.4	8.4	pKd	2
Homo sapiens	Platelet-derived growth factor receptor beta	8.2	8.2	8.2	pKi	1
Homo sapiens	Protein kinase C delta	5.7	5.7	5.7	pKi	1
Homo sapiens	Protein kinase C nu	5.9	5.9	5.9	pKi	1
Homo sapiens	Protein kinase C theta	5.5	5.5	5.5	pKd	2
Homo sapiens	Protein kinase N1	6.8	6.8	6.8	pKd	2
Homo sapiens	Protein kinase N2	5	5	5	pKd	2
Homo sapiens	Protein kinase N2	6.2	6.2	6.2	pKi	1
Homo sapiens	Proto-oncogene tyrosine-protein kinase MER	5.8	5.8	5.8	pKd	2
Homo sapiens	Receptor-interacting serine/threonine-protein kinase 1	6.5	6.5	6.5	pKd	2
Homo sapiens	Rho-associated protein kinase 1	6.1	6.1	6.1	pKd	1
Homo sapiens	Rho-associated protein kinase 2	5.5	5.5	5.5	pKd	1
Homo sapiens	Rho-associated protein kinase 2	5.4	5.4	5.4	pKi	1
Homo sapiens	Rhodopsin kinase	5.7	5.7	5.7	pKd	1
Homo sapiens	Ribosomal protein S6 kinase 1	6.2	6.2	6.2	pKd	1
Homo sapiens	Ribosomal protein S6 kinase 1	7	7	7	pKi	1
Homo sapiens	Ribosomal protein S6 kinase alpha 1	6.4	6.4	6.4	pKd	4
Homo sapiens	Ribosomal protein S6 kinase alpha 2	6.5	6.5	6.5	pKd	4
Homo sapiens	Ribosomal protein S6 kinase alpha 3	5.3	5.3	5.3	pKd	4
Homo sapiens	Ribosomal protein S6 kinase alpha 3	6.5	6.5	6.5	pKi	2
Homo sapiens	Ribosomal protein S6 kinase alpha 4	6.2	6.2	6.2	pKd	4
Homo sapiens	Ribosomal protein S6 kinase alpha 5	6.2	6.2	6.2	pKd	4
Homo sapiens	Ribosomal protein S6 kinase alpha 5	6	6	6	pKi	2
Homo sapiens	Ribosomal protein S6 kinase alpha 6	5.3	5.3	5.3	pKd	4
Homo sapiens	Serine/threonine-protein kinase 10	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase 11	5.4	5.4	5.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase 16	5.8	5.8	5.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase 17A	6.1	6.1	6.1	pKd	2
Homo sapiens	Serine/threonine-protein kinase 17B	5.8	5.8	5.8	pKd	2
Homo sapiens	Serine/threonine-protein kinase 2	6.5	6.5	6.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase 2	6.7	6.7	6.7	pKi	1
Homo sapiens	Serine/threonine-protein kinase 24	6.4	6.4	6.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase 25	5.9	5.9	5.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase 38	6.2	6.2	6.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase Aurora-B	6.6	6.6	6.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase Aurora-B	7.1	7.1	7.1	pKi	1
Homo sapiens	Serine/threonine-protein kinase Aurora-C	6	6	6	pKd	2
Homo sapiens	Serine/threonine-protein kinase Chk1	5.9	5.9	5.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase Chk1	6.8	6.8	6.8	pKi	1
Homo sapiens	Serine/threonine-protein kinase Chk2	5.8	5.8	5.8	pKi	1
Homo sapiens	Serine/threonine-protein kinase c-TAK1	5.5	5.5	5.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase c-TAK1	6.9	6.9	6.9	pKi	1
Homo sapiens	Serine/threonine-protein kinase D2	5.7	5.7	5.7	pKi	1
Homo sapiens	Serine/threonine-protein kinase DCLK3	5.9	5.9	5.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase GAK	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase LATS1	5.8	5.8	5.8	pKd	2
Homo sapiens	Serine/threonine-protein kinase LATS2	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase MARK1	5.6	5.6	5.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase MST1	6.7	6.7	6.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase MST2	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase MST2	6.7	6.7	6.7	pKi	1
Homo sapiens	Serine/threonine-protein kinase MST4	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase NEK2	5.7	5.7	5.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase NEK2	6.3	6.3	6.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase Nek4	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase Nek4	5.3	5.3	5.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase Nek5	5.6	5.6	5.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase NEK6	5.8	5.8	5.8	pKd	2
Homo sapiens	Serine/threonine-protein kinase NEK7	5.3	5.3	5.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase NEK9	5	5	5	pKd	2
Homo sapiens	Serine/threonine-protein kinase NIM1	6.1	6.1	6.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase PAK 3	6.1	6.1	6.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase PAK 4	5.7	5.7	5.7	pKi	1
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-1	6.4	6.4	6.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-2	5.5	5.5	5.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-3	5.1	5.1	5.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase PIM2	5.9	5.9	5.9	pKi	1
Mycobacterium tuberculosis	Serine/threonine-protein kinase pknB	6.5	6.5	6.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK2	6.2	6.2	6.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK4	5.9	5.9	5.9	pKi	1
Homo sapiens	Serine/threonine-protein kinase PRKX	5.8	5.8	5.8	pKi	1
Homo sapiens	Serine/threonine-protein kinase PRP4 homolog	6.3	6.3	6.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIO1	6.4	6.4	6.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase RIO2	6.6	6.6	6.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIO3	6.2	6.2	6.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase SBK1	5.8	5.8	5.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase Sgk2	5.9	5.9	5.9	pKi	1
Homo sapiens	Serine/threonine-protein kinase Sgk3	6	6	6	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK2	5.4	5.4	5.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase SIK2	7	7	7	pKi	1
Homo sapiens	Serine/threonine-protein kinase SRPK1	6.4	6.4	6.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase SRPK1	5.3	5.3	5.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase SRPK2	6.5	6.5	6.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase SRPK3	6.6	6.6	6.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase TBK1	6.9	6.9	6.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase tousled-like 2	5.6	5.6	5.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase ULK1	7.3	7.3	7.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase ULK2	7.3	7.3	7.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase ULK3	6.8	6.8	6.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase WEE1	5.9	5.9	5.9	pKd	2
Homo sapiens	SPS1/STE20-related protein kinase YSK4	7.9	7.9	7.9	pKd	1
Homo sapiens	STE20/SPS1-related proline-alanine-rich protein kinase	6.3	6.3	6.3	pKd	1
Homo sapiens	Stem cell growth factor receptor	8.5	7.3	9	pIC50	4
Homo sapiens	Stem cell growth factor receptor	8.1	5.9	8.8	pKd	15
Homo sapiens	Stem cell growth factor receptor	7.7	7.7	7.7	pKi	1
Homo sapiens	Testis-specific serine/threonine-protein kinase 1	6.3	6.3	6.3	pKi	1
Homo sapiens	TRAF2- and NCK-interacting kinase	8.1	7.2	8.7	pIC50	3
Homo sapiens	TRAF2- and NCK-interacting kinase	7.6	7.6	7.6	pKd	3
Homo sapiens	Tyrosine-protein kinase ABL	6.4	6.4	6.6	pIC50	2
Homo sapiens	Tyrosine-protein kinase ABL	7	5.2	7.5	pKd	21
Homo sapiens	Tyrosine-protein kinase ABL	7	7	7	pKi	1
Homo sapiens	Tyrosine-protein kinase BLK	6.7	6.7	6.7	pKd	2
Homo sapiens	Tyrosine-protein kinase BLK	7.9	7.9	7.9	pKi	1
Homo sapiens	Tyrosine-protein kinase BTK	5.7	5.7	5.7	pKi	1
Homo sapiens	Tyrosine-protein kinase FGR	6.7	6.7	6.7	pKd	2
Homo sapiens	Tyrosine-protein kinase FRK	5.6	5.6	5.6	pKd	2
Homo sapiens	Tyrosine-protein kinase FYN	6.4	6.4	6.4	pKd	2
Homo sapiens	Tyrosine-protein kinase FYN	7.2	7.2	7.2	pKi	1
Homo sapiens	Tyrosine-protein kinase HCK	5.5	5.5	5.5	pKd	2
Homo sapiens	Tyrosine-protein kinase HCK	6.8	6.8	6.8	pKi	1
Homo sapiens	Tyrosine-protein kinase ITK/TSK	6.3	6.3	6.3	pKd	2
Homo sapiens	Tyrosine-protein kinase ITK/TSK	7.3	7.3	7.3	pKi	1
Homo sapiens	Tyrosine-protein kinase JAK1	6.4	6.4	6.4	pKd	4
Homo sapiens	Tyrosine-protein kinase JAK2	5.2	5.2	6.9	pKd	4
Homo sapiens	Tyrosine-protein kinase JAK2	6	6	6	pKi	2
Homo sapiens	Tyrosine-protein kinase JAK3	5.1	5.1	6.4	pKd	4
Homo sapiens	Tyrosine-protein kinase LCK	6.6	6.6	6.6	pKd	2
Homo sapiens	Tyrosine-protein kinase LCK	7.7	7.7	7.7	pKi	1
Homo sapiens	Tyrosine-protein kinase Lyn	6.1	6.1	6.1	pKd	2
Homo sapiens	Tyrosine-protein kinase Lyn	7.2	7.2	7.2	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor FLT3	8.5	8.5	9	pIC50	2
Homo sapiens	Tyrosine-protein kinase receptor FLT3	8.3	8.1	9.2	pKd	12
Homo sapiens	Tyrosine-protein kinase receptor FLT3	8.5	8.5	8.5	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor RET	7.3	7.2	7.6	pKd	6
Homo sapiens	Tyrosine-protein kinase receptor RET	8.3	8.3	8.3	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor Tie-1	5.4	5.4	5.4	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	5	5	5	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	7.3	7.3	7.3	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor UFO	5.4	5.4	5.4	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor UFO	6.6	6.6	6.6	pKi	1
Gallus gallus	Tyrosine-protein kinase SRC	7.1	7.1	7.1	pIC50	1
Homo sapiens	Tyrosine-protein kinase SRC	5.8	5.8	5.8	pKd	2
Homo sapiens	Tyrosine-protein kinase SRC	7.2	7.2	7.2	pKi	1
Homo sapiens	Tyrosine-protein kinase TYK2	5.7	5.7	6.8	pKd	4
Homo sapiens	Tyrosine-protein kinase TYK2	6.7	6.7	6.7	pKi	2
Homo sapiens	Tyrosine-protein kinase YES	7.5	7.5	8.9	pIC50	2
Homo sapiens	Tyrosine-protein kinase YES	6.2	6.2	6.2	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 1	8	8	8.5	pIC50	2
Homo sapiens	Vascular endothelial growth factor receptor 1	7.2	7.2	7.2	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 1	7.4	7.4	7.4	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 2	7.3	7.3	7.3	pEC50	1
Homo sapiens	Vascular endothelial growth factor receptor 2	7.2	7.2	7.9	pIC50	2
Homo sapiens	Vascular endothelial growth factor receptor 2	7.2	7.2	7.2	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 2	7.7	7.7	7.7	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 3	8.5	8.1	8.6	pIC50	3
Homo sapiens	Vascular endothelial growth factor receptor 3	6.2	6.2	6.2	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 3	7	7	7	pKi	1

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 Q
594

2 L
595

3 L
596

4 G
597

5 K
598

6 G
599

7 A
600

8 F
601

9 G
602

10 A
603

11 V
604

12 I
605

13 K
606

14 Y
616

15 A
617

16 V
618

17 K
619

18 R
620

19 I
621

20 R
632

•

αC

b.l

21 I
633

22 K
634

23 G
635

24 E
636

25 V
637

26 T
638

27 L
639

28 L
640

29 S
641

30 R
642

31 L
643

32 H
644

33 E
646

34 N
647

35 I
648

36 V
649

37 R
650

38 Y
651

39 Y
652

40 N
653

•

hinge

linker

αD

αE

41 A
654

42 _
_

43 _
_

44 _
_

45 _
_

46 _
_

47 _
_

48 _
_

49 _
_

50 _
_

51 _
_

52 _
_

53 _
_

54 _
_

55 _
_

56 _
_

57 _
_

58 _
_

59 _
_

60 Y
838

αE

c.l

VII

VIII

61 I
839

62 H
840

63 E
841

64 K
842

65 G
843

66 M
844

67 I
845

68 H
846

69 R
847

70 N
848

71 L
849

72 K
850

73 P
851

74 V
852

75 N
853

76 I
854

77 F
855

78 L
856

79 I
864

80 G
865

•••

DFG

a.l

81 D
866

82 F
867

83 G
868

84 _
_

85 _
_

•

Interaction pattern search

Search KLIFS for kinase-ligand complexes with similar interaction patterns: