KLIFS - the kinase structures database

Version: 3.2
Updated: 29-Oct-2025

Kinase structure
Kinase:	RPS6KB1 (p70S6K)
Family:	RSK
Group:	AGC
Species:	HUMAN
IUPHAR/BPS ID:	1525
PDB:	3A60
sc-PDB:
KIDFamMap:	Search
Release date:	2009-10-27
PubMed:	19864428
Chain:	B
Orthosteric ligand:	STU

More entries for 3A60
3A60	Chain:	A

Structural information
DFG conformation:	out
αC-helix conformation:	na
G-rich loop angle (distance):	50.1° (15.5Å)
G-rich loop rotation:	69.5°
Quality Score:	4
Resolution:	2.8 Å
Missing Residues:	13
Missing Atoms:	0

Ligand binding mode
Pockets	Subpockets
front

Pocket alignment
Uniprot sequence:	RVLGKGGYGKVFQFAMKVLHTKAERNILEEVKPFIVDLIYAYLILEYLSGGELFMQLERHLHQKGIIYRDLKPENIMLLTDFGLC
Sequence structure:	RVLGKGGYGKVFQFAMKVL_____________PFIVDLIYAYLILEYLSGGELFMQLERHLHQKGIIYRDLKPENIMLLTDFGLC

Ligand affinity
ChEMBL ID:	CHEMBL388978
Bioaffinities:	1452 records for 364 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	3-phosphoinositide dependent protein kinase-1	8	8	8.3	pIC50	2
Homo sapiens	3-phosphoinositide dependent protein kinase-1	8.8	8.8	8.8	pKd	2
Homo sapiens	Activin receptor type-1	5	5	5	pIC50	1
Homo sapiens	Activin receptor type-1	6.3	6.3	6.3	pKd	2
Homo sapiens	Activin receptor type-1B	5	5	5	pIC50	1
Homo sapiens	Activin receptor type-1B	6.2	6.2	6.2	pKd	2
Homo sapiens	Activin receptor type-2A	5.1	5.1	5.1	pKd	1
Homo sapiens	Activin receptor type-2B	5.3	5.3	5.3	pKd	2
Homo sapiens	Adaptor-associated kinase	8.9	8.9	8.9	pKd	3
Homo sapiens	ALK tyrosine kinase receptor	8.5	7.5	9.2	pIC50	14
Homo sapiens	ALK tyrosine kinase receptor	7.5	7.5	7.5	pKd	2
Homo sapiens	AMP-activated protein kinase, alpha-1 subunit	8.4	8.1	8.4	pKd	3
Homo sapiens	AMP-activated protein kinase, alpha-2 subunit	7.9	7.9	7.9	pKd	2
Homo sapiens	Ankyrin repeat and protein kinase domain-containing protein 1	6.6	6.6	6.6	pKd	2
Homo sapiens	BMP-2-inducible protein kinase	8.3	8.3	8.4	pKd	3
Homo sapiens	Bone morphogenetic protein receptor type-1A	5.4	5.4	5.4	pIC50	1
Homo sapiens	Bone morphogenetic protein receptor type-1A	5.4	5.4	5.4	pKd	2
Homo sapiens	Bone morphogenetic protein receptor type-1B	6.8	6.8	6.8	pKd	1
Homo sapiens	Bone morphogenetic protein receptor type-2	5.6	5.6	5.6	pKd	1
Homo sapiens	BR serine/threonine-protein kinase 1	7.6	7.6	7.6	pKd	2
Homo sapiens	BR serine/threonine-protein kinase 2	8.5	8.5	8.5	pKd	2
Plasmodium falciparum (isolate 3D7)	Calcium-dependent protein kinase 1	9.6	9.6	9.6	pKd	1
Homo sapiens	CaM kinase I alpha	7.6	7.5	7.6	pKd	3
Homo sapiens	CaM kinase I delta	9	8.7	9	pKd	3
Homo sapiens	CaM kinase I gamma	7.6	7.3	7.6	pKd	3
Homo sapiens	CaM kinase II alpha	9.8	9.8	10	pKd	3
Homo sapiens	CaM kinase II beta	10.2	10.2	10.2	pIC50	1
Homo sapiens	CaM kinase II beta	8.9	8.5	8.9	pKd	3
Homo sapiens	CaM kinase II delta	9.5	9.3	9.5	pKd	3
Homo sapiens	CaM kinase II gamma	9.3	9.3	9.3	pKd	3
Homo sapiens	CaM kinase IV	7.4	7.4	7.4	pKd	2
Homo sapiens	CaM-kinase kinase alpha	10.4	10.3	10.4	pKd	3
Homo sapiens	CaM-kinase kinase beta	9.8	9.8	10.3	pKd	3
Bos taurus	cAMP-dependent protein kinase alpha-catalytic subunit	7.4	7.4	7.4	pIC50	1
Homo sapiens	cAMP-dependent protein kinase alpha-catalytic subunit	8.6	8.6	8.8	pIC50	2
Homo sapiens	cAMP-dependent protein kinase alpha-catalytic subunit	7.7	7.7	7.7	pKd	2
Rattus norvegicus	cAMP-dependent protein kinase alpha-catalytic subunit	7.6	6.9	7.8	pIC50	3
Homo sapiens	cAMP-dependent protein kinase beta-1 catalytic subunit	7.5	7.5	7.5	pIC50	1
Homo sapiens	cAMP-dependent protein kinase beta-1 catalytic subunit	7.5	7.5	7.5	pKd	2
Homo sapiens	Casein kinase I alpha	5.4	5.4	5.4	pIC50	1
Homo sapiens	Casein kinase I alpha	6	6	6	pKd	1
Homo sapiens	Casein kinase I delta	5.6	5.6	5.6	pKd	2
Homo sapiens	Casein kinase I epsilon	7.1	6.2	7.1	pKd	3
Homo sapiens	Casein kinase I gamma 1	5.5	5.5	5.5	pKd	1
Homo sapiens	Casein kinase I gamma 2	6.1	5.9	6.1	pKd	3
Homo sapiens	Casein kinase II alpha	5.4	5.4	5.4	pIC50	1
Homo sapiens	Casein kinase II alpha	6	6	7.4	pKd	2
Homo sapiens	Casein kinase II alpha (prime)	6.6	6.6	8.2	pKd	2
Homo sapiens	Casein kinase I isoform alpha-like	6.6	6.6	6.6	pKd	2
Plasmodium falciparum (isolate 3D7)	Cell division control protein 2 homolog	6.1	6.1	6.1	pKd	1
Homo sapiens	Cell division cycle 2-like protein kinase 6	6.7	6.7	6.7	pKd	2
Homo sapiens	Cell division protein kinase 8	6.3	6.3	6.3	pKd	2
Bos taurus	cGMP-dependent protein kinase 1 alpha	7.8	7.8	7.8	pIC50	2
Homo sapiens	cGMP-dependent protein kinase 1 beta	8.3	8.3	8.3	pIC50	1
Homo sapiens	cGMP-dependent protein kinase 1 beta	7.5	7.5	7.5	pKd	2
Homo sapiens	cGMP-dependent protein kinase 2	7.8	7.8	7.8	pKd	2
Homo sapiens	Citron Rho-interacting kinase	6.5	6.5	6.5	pKd	2
Homo sapiens	c-Jun N-terminal kinase 1	5.8	5.5	6.2	pIC50	3
Homo sapiens	c-Jun N-terminal kinase 1	6.7	6.3	6.7	pKd	3
Homo sapiens	c-Jun N-terminal kinase 2	5.6	5.6	5.6	pIC50	1
Homo sapiens	c-Jun N-terminal kinase 2	6	6	6	pKd	2
Homo sapiens	c-Jun N-terminal kinase 3	7	6.5	7	pKd	3
Homo sapiens	Cyclin-dependent kinase 1	8.1	7.8	9.4	pIC50	4
Mus musculus	Cyclin-dependent kinase 1	8.1	8.1	8.1	pIC50	1
Homo sapiens	Cyclin-dependent kinase 2	8.9	8.4	10	pIC50	5
Homo sapiens	Cyclin-dependent kinase 2	8.2	8.1	8.2	pKd	3
Homo sapiens	Cyclin-dependent kinase 3	8.2	8.2	8.2	pIC50	1
Homo sapiens	Cyclin-dependent kinase 3	7.5	7.5	7.5	pKd	2
Homo sapiens	Cyclin-dependent kinase 4	7.3	7.3	7.7	pKd	2
Homo sapiens	Cyclin-dependent kinase 5	7.1	7.1	7.1	pKd	3
Homo sapiens	Cyclin-dependent kinase 7	7.4	7.4	7.4	pKd	2
Homo sapiens	Cyclin-dependent kinase 9	7	7	7	pKd	2
Homo sapiens	Cyclin-dependent kinase-like 1	6.5	6.5	6.5	pKd	1
Homo sapiens	Cyclin-dependent kinase-like 2	6.3	6.3	6.3	pKd	1
Homo sapiens	Cyclin-dependent kinase-like 3	5.3	5.3	5.3	pKd	1
Homo sapiens	Cyclin-dependent kinase-like 5	6.5	6.5	6.5	pKd	1
Homo sapiens	Death-associated protein kinase 1	8	7.9	9.3	pIC50	3
Homo sapiens	Death-associated protein kinase 1	8.9	8.9	8.9	pKd	2
Homo sapiens	Death-associated protein kinase 2	8.8	8.5	8.8	pKd	3
Homo sapiens	Death-associated protein kinase 3	9	5.8	9	pKd	4
Homo sapiens	Discoidin domain-containing receptor 2	7.4	7.4	7.4	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	7.3	6.2	8.6	pIC50	8
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	7.7	7.7	7.7	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	7.6	7.6	7.6	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 3	8.3	8.3	8.3	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 4	7.2	7.2	7.2	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 5	8.5	8.5	8.5	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 6	8.5	8.5	8.5	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 7	7.5	7.5	7.5	pKd	1
Homo sapiens	Dual specificity protein kinase CLK2	8.1	7.9	8.1	pKd	3
Homo sapiens	Dual specificity protein kinase CLK3	6	5.5	6	pKd	3
Homo sapiens	Dual specificity protein kinase CLK4	8	7.8	8	pKd	3
Homo sapiens	Dual specificity protein kinase TTK	7.2	7	7.2	pKd	3
Homo sapiens	Dual specificity testis-specific protein kinase 1	6.5	6.5	6.5	pKd	2
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	7.7	7.7	7.7	pIC50	1
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	8.4	8.4	8.4	pKd	1
Homo sapiens	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	7.6	7.6	7.6	pKd	2
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 2	6.6	6.6	6.6	pKd	1
Homo sapiens	Dual specificty protein kinase CLK1	7.5	7.5	7.6	pKd	3
Homo sapiens	Ephrin type-A receptor 1	7.3	7.3	7.3	pIC50	1
Homo sapiens	Ephrin type-A receptor 1	6.5	6.5	6.5	pKd	2
Homo sapiens	Ephrin type-A receptor 2	6.6	6.6	6.6	pIC50	1
Homo sapiens	Ephrin type-A receptor 2	5.9	5.9	6.1	pKd	3
Homo sapiens	Ephrin type-A receptor 3	7.3	7.3	7.7	pIC50	2
Homo sapiens	Ephrin type-A receptor 3	7.6	7.3	7.6	pKd	3
Homo sapiens	Ephrin type-A receptor 4	6.5	6.2	6.5	pKd	3
Homo sapiens	Ephrin type-A receptor 5	7	6.8	7	pKd	3
Homo sapiens	Ephrin type-A receptor 6	6.5	6.5	6.6	pKd	3
Homo sapiens	Ephrin type-A receptor 7	6.2	6.2	6.2	pKd	3
Homo sapiens	Ephrin type-A receptor 8	6.7	6.5	6.7	pKd	3
Homo sapiens	Ephrin type-B receptor 1	6.9	6.9	6.9	pIC50	1
Homo sapiens	Ephrin type-B receptor 1	6.6	6.2	6.6	pKd	3
Homo sapiens	Ephrin type-B receptor 2	6.7	6.7	6.7	pIC50	1
Homo sapiens	Ephrin type-B receptor 2	5.7	5.7	5.7	pKd	2
Homo sapiens	Ephrin type-B receptor 4	6.6	6.6	6.9	pIC50	2
Homo sapiens	Ephrin type-B receptor 4	5.7	5.7	5.7	pKd	1
Homo sapiens	Epidermal growth factor receptor erbB1	7.3	6.6	9.5	pIC50	18
Homo sapiens	Epidermal growth factor receptor erbB1	6.5	6	9.5	pKd	23
Homo sapiens	Epithelial discoidin domain-containing receptor 1	7.7	7.7	7.7	pKd	2
Homo sapiens	Eukaryotic translation initiation factor 2-alpha kinase 4	7.8	7.8	7.8	pKd	2
Homo sapiens	Fibroblast growth factor receptor 1	8.1	8.1	8.2	pIC50	2
Homo sapiens	Fibroblast growth factor receptor 1	7.1	7.1	7.2	pKd	3
Homo sapiens	Fibroblast growth factor receptor 2	8.2	7.5	8.8	pIC50	4
Homo sapiens	Fibroblast growth factor receptor 2	7	6.8	7	pKd	3
Homo sapiens	Fibroblast growth factor receptor 3	7.8	7.8	8	pIC50	5
Homo sapiens	Fibroblast growth factor receptor 3	7	6.5	7.1	pKd	5
Homo sapiens	Fibroblast growth factor receptor 4	6.8	6.8	6.8	pIC50	1
Homo sapiens	Fibroblast growth factor receptor 4	6.6	6.6	6.6	pKd	2
Homo sapiens	Focal adhesion kinase 1	7.3	5.5	8	pIC50	9
Homo sapiens	Focal adhesion kinase 1	7.2	7.2	7.2	pKd	3
Homo sapiens	Glycogen synthase kinase-3 alpha	7.6	7.6	7.6	pIC50	1
Homo sapiens	Glycogen synthase kinase-3 alpha	6.9	6.9	6.9	pKd	2
Homo sapiens	Glycogen synthase kinase-3 beta	7.5	6.7	8.6	pIC50	25
Homo sapiens	Glycogen synthase kinase-3 beta	7.2	7.2	7.2	pKd	2
Homo sapiens	Glycogen synthase kinase-3 beta	7.7	7.7	7.7	pKi	1
Homo sapiens	G protein-coupled receptor kinase 4	7.4	7.4	7.4	pKd	1
Homo sapiens	G protein-coupled receptor kinase 6	4.5	4.5	4.5	pIC50	1
Homo sapiens	G protein-coupled receptor kinase 7	9.1	9.1	9.1	pKd	1
Homo sapiens	Hepatocyte growth factor receptor	6.9	6	7.2	pIC50	13
Homo sapiens	Hepatocyte growth factor receptor	6.7	6.7	6.9	pKd	4
Homo sapiens	Homeodomain-interacting protein kinase 1	5.6	5.6	5.6	pIC50	1
Homo sapiens	Homeodomain-interacting protein kinase 1	5.6	5.6	5.6	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 2	6.7	6.7	6.7	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 3	7.1	7.1	7.1	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 4	6.4	6.4	6.4	pKd	1
Homo sapiens	Hormonally up-regulated neu tumor-associated kinase	6.2	6.2	6.2	pKd	1
Homo sapiens	Inhibitor of nuclear factor kappa B kinase alpha subunit	6.6	6.6	7.4	pIC50	2
Homo sapiens	Inhibitor of nuclear factor kappa B kinase alpha subunit	8.2	8.2	8.2	pKd	1
Homo sapiens	Inhibitor of nuclear factor kappa B kinase beta subunit	6.3	5.9	9.1	pIC50	7
Homo sapiens	Inhibitor of nuclear factor kappa B kinase beta subunit	7.5	7.5	7.5	pKd	1
Homo sapiens	Inhibitor of nuclear factor kappa B kinase epsilon subunit	8.3	8.3	8.3	pKd	2
Homo sapiens	Insulin-like growth factor I receptor	6.7	5.8	7.5	pIC50	11
Homo sapiens	Insulin-like growth factor I receptor	6.7	6.7	6.7	pKd	2
Homo sapiens	Insulin receptor	7.8	7.1	8.1	pIC50	3
Homo sapiens	Insulin receptor	7	7	7.1	pKd	3
Mus musculus	Insulin receptor	6.7	6.7	6.7	pIC50	1
Homo sapiens	Insulin receptor-related protein	7.1	7.1	7.1	pKd	2
Homo sapiens	Interferon-induced, double-stranded RNA-activated protein kinase	6.4	6.4	6.4	pKd	2
Homo sapiens	Interleukin-1 receptor-associated kinase 1	7.4	7.4	7.4	pKd	1
Homo sapiens	Interleukin-1 receptor-associated kinase 3	7.9	7.9	7.9	pKd	2
Homo sapiens	Interleukin-1 receptor-associated kinase 4	7.5	7.5	8.2	pIC50	2
Homo sapiens	Interleukin-1 receptor-associated kinase 4	8.8	8.8	8.8	pKd	1
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	9	9	9	pIC50	1
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	8.5	8.5	9.4	pKd	2
Homo sapiens	Leukocyte tyrosine kinase receptor	8.4	8.4	8.4	pIC50	1
Homo sapiens	Leukocyte tyrosine kinase receptor	7.4	7.4	7.4	pKd	2
Homo sapiens	LIM domain kinase 1	6.3	6.2	6.3	pKd	3
Homo sapiens	LIM domain kinase 2	5	5	5	pKd	2
Homo sapiens	Macrophage colony stimulating factor receptor	8.5	6	8.9	pIC50	3
Homo sapiens	Macrophage colony stimulating factor receptor	7.9	7.9	7.9	pKd	2
Homo sapiens	Macrophage-stimulating protein receptor	6.5	6.4	7	pIC50	3
Homo sapiens	Macrophage-stimulating protein receptor	6.4	6.4	6.4	pKd	1
Homo sapiens	MAP kinase-activated protein kinase 2	6.2	5.5	7.4	pIC50	8
Homo sapiens	MAP kinase-activated protein kinase 2	6.1	6.1	6.1	pKd	2
Homo sapiens	MAP kinase-activated protein kinase 5	6.6	6.6	6.6	pKd	1
Homo sapiens	MAP kinase ERK1	5.3	4.6	5.9	pIC50	9
Homo sapiens	MAP kinase ERK1	5.1	5.1	5.1	pKd	2
Homo sapiens	MAP kinase ERK2	5.9	5.1	8.6	pIC50	8
Homo sapiens	MAP kinase ERK2	5.1	5.1	5.1	pKd	2
Homo sapiens	MAP kinase-interacting serine/threonine-protein kinase MNK1	6.8	6.8	6.8	pKd	2
Homo sapiens	MAP kinase p38 alpha	5.2	5.2	8	pIC50	2
Homo sapiens	MAP kinase p38 delta	6.6	6.6	6.6	pKd	1
Homo sapiens	MAP kinase p38 gamma	7.4	7	7.4	pKd	3
Homo sapiens	MAP kinase signal-integrating kinase 2	7.6	7.6	7.6	pIC50	1
Homo sapiens	MAP kinase signal-integrating kinase 2	7.8	7.7	7.8	pKd	3
Homo sapiens	MAP/microtubule affinity-regulating kinase 2	9.2	9.2	10	pKd	3
Homo sapiens	MAP/microtubule affinity-regulating kinase 4	8.3	8.3	8.3	pKd	2
Homo sapiens	Maternal embryonic leucine zipper kinase	7.5	7.5	7.5	pKd	2
Homo sapiens	Microtubule-associated serine/threonine-protein kinase 1	6.8	6.8	6.8	pKd	1
Homo sapiens	Misshapen-like kinase 1	9.3	9.3	9.3	pIC50	2
Homo sapiens	Misshapen-like kinase 1	9	9	9	pKd	1
Homo sapiens	Mitogen-activated protein kinase 15	8.1	8.1	8.1	pIC50	1
Homo sapiens	Mitogen-activated protein kinase 15	7.5	7.5	7.5	pKd	2
Homo sapiens	Mitogen-activated protein kinase 6	5.5	5.5	5.5	pKd	1
Homo sapiens	Mitogen-activated protein kinase 7	5.2	5.2	6.9	pIC50	2
Homo sapiens	Mitogen-activated protein kinase 7	5.8	5.8	5.8	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 1	6.5	6.5	6.5	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 10	7.3	7.3	7.3	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 11	7.7	7.7	7.7	pKd	3
Homo sapiens	Mitogen-activated protein kinase kinase kinase 12	5.8	5.8	5.8	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 13	6.7	6.7	6.7	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 14	5.6	5.6	5.6	pIC50	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 15	8.6	8.6	8.6	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 2	8.6	8.6	8.6	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 3	5.6	5.6	5.6	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 4	5.9	5.7	5.9	pKd	3
Homo sapiens	Mitogen-activated protein kinase kinase kinase 5	7.4	6	9.2	pIC50	3
Homo sapiens	Mitogen-activated protein kinase kinase kinase 5	7	6.9	7	pKd	4
Homo sapiens	Mitogen-activated protein kinase kinase kinase 6	6.6	6.6	6.6	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 7	7.4	7.4	7.5	pIC50	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 7	7.2	7.2	7.2	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 9	8	8	8	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 1	8.4	8.4	8.4	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	8.1	8.1	8.1	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 3	8.1	8.1	8.1	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 4	7.6	7.6	7.6	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	7.8	7.6	7.8	pKd	3
Homo sapiens	Muscle, skeletal receptor tyrosine protein kinase	8.4	8.4	8.4	pIC50	1
Homo sapiens	Muscle, skeletal receptor tyrosine protein kinase	7.1	7.1	7.1	pKd	2
Homo sapiens	Myosin IIIA	6.3	6.3	6.3	pKd	2
Homo sapiens	Myosin-IIIB	6.5	6.5	6.5	pKd	2
Homo sapiens	Myosin light chain kinase	6.9	6.9	6.9	pKd	1
Homo sapiens	myosin light chain kinase 2	7.2	7	7.2	pKd	3
Homo sapiens	Myosin light chain kinase family member 4	6.3	6.3	6.3	pKd	2
Gallus gallus	Myosin light chain kinase, smooth muscle	8	8	8	pIC50	1
Gallus gallus	Myosin light chain kinase, smooth muscle	6.9	6.9	6.9	pKd	1
Homo sapiens	Myosin light chain kinase, smooth muscle	7.4	7.4	8	pIC50	2
Homo sapiens	Myosin light chain kinase, smooth muscle	7.8	7.8	7.8	pKd	2
Homo sapiens	Myotonin-protein kinase	8.5	8.5	8.5	pKd	2
Homo sapiens	Nerve growth factor receptor Trk-A	8.8	8.1	9.3	pIC50	5
Homo sapiens	Nerve growth factor receptor Trk-A	8.4	8.4	8.7	pKd	3
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	8.4	8.4	9	pIC50	2
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	8.4	8.4	8.4	pKd	2
Homo sapiens	Non-receptor tyrosine-protein kinase TNK1	8.6	8.6	8.6	pKd	2
Homo sapiens	NT-3 growth factor receptor	7.8	7.8	7.8	pKd	2
Homo sapiens	NUAK family SNF1-like kinase 1	8.1	8.1	8.1	pIC50	1
Homo sapiens	NUAK family SNF1-like kinase 1	8.4	8.4	8.4	pKd	2
Homo sapiens	NUAK family SNF1-like kinase 2	10.1	10.1	10.1	pKd	2
Homo sapiens	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha	7.4	7.4	7.4	pKd	2
Homo sapiens	Phosphatidylinositol-5-phosphate 4-kinase type-2 beta	7.1	7.1	7.1	pKd	2
Homo sapiens	Phosphorylase kinase gamma subunit 1	9.2	9.2	9.3	pKd	3
Homo sapiens	Phosphorylase kinase gamma subunit 2	9.3	9.3	9.3	pIC50	1
Homo sapiens	Phosphorylase kinase gamma subunit 2	9.9	9	9.9	pKd	3
Homo sapiens	Platelet-derived growth factor receptor alpha	9.4	9.2	9.4	pIC50	3
Homo sapiens	Platelet-derived growth factor receptor alpha	8	8	8	pKd	2
Homo sapiens	Platelet-derived growth factor receptor beta	8.4	6.7	9.2	pIC50	5
Homo sapiens	Platelet-derived growth factor receptor beta	8.7	8.6	8.7	pKd	3
Homo sapiens	Protein kinase C alpha	8.5	7.4	9.4	pIC50	12
Homo sapiens	Protein kinase C alpha	7.3	7.3	7.3	pKd	1
Homo sapiens	Protein kinase C beta	7.6	7.1	8.4	pIC50	11
Homo sapiens	Protein kinase C delta	7.4	6.2	8.3	pIC50	7
Homo sapiens	Protein kinase C delta	8.8	8.8	8.8	pKd	2
Homo sapiens	Protein kinase C epsilon	7.9	7.7	9.2	pIC50	8
Homo sapiens	Protein kinase C epsilon	9.6	9.6	9.6	pKd	2
Homo sapiens	Protein kinase C eta	8.3	8.3	8.3	pIC50	2
Homo sapiens	Protein kinase C eta	8.3	8.3	8.3	pKd	2
Homo sapiens	Protein kinase C gamma	7.2	7	8.6	pIC50	7
Rattus norvegicus	Protein kinase C gamma	8.1	8.1	8.1	pIC50	1
Homo sapiens	Protein kinase C iota	6.4	6.4	6.4	pIC50	1
Homo sapiens	Protein kinase C iota	7.6	7.6	7.6	pKd	1
Homo sapiens	Protein kinase C mu	7.6	7.6	7.6	pKd	2
Homo sapiens	Protein kinase C nu	7.8	7.8	7.8	pKd	2
Homo sapiens	Protein kinase C theta	8.1	8.1	8.1	pKd	2
Homo sapiens	Protein kinase C zeta	6.7	6.7	6.7	pIC50	1
Homo sapiens	Protein kinase N1	8.9	8.9	9	pIC50	2
Homo sapiens	Protein kinase N1	8.9	8.9	8.9	pKd	2
Homo sapiens	Protein kinase N2	8.7	8.7	8.7	pIC50	1
Homo sapiens	Protein kinase N2	8.6	8.6	8.6	pKd	2
Plasmodium falciparum	Protein kinase Pfmrk	5.4	5.4	5.4	pIC50	2
Homo sapiens	Protein tyrosine kinase 2 beta	8.5	8.5	8.5	pKd	2
Homo sapiens	Proto-oncogene tyrosine-protein kinase MER	7.1	7.1	7.1	pIC50	1
Homo sapiens	Proto-oncogene tyrosine-protein kinase MER	8.2	8.2	8.2	pKd	2
Homo sapiens	Proto-oncogene tyrosine-protein kinase ROS	9.7	9.7	10.2	pIC50	2
Homo sapiens	Proto-oncogene tyrosine-protein kinase ROS	7.5	7.5	7.5	pKd	2
Homo sapiens	Putative uncharacterized serine/threonine-protein kinase SgK110	7.6	7.6	7.6	pKd	1
Homo sapiens	Receptor-interacting serine/threonine-protein kinase 4	7	7	7	pKd	1
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	7.2	6.9	7.5	pIC50	3
Homo sapiens	Receptor protein-tyrosine kinase erbB-2	6.7	6.7	6.7	pKd	1
Homo sapiens	Receptor protein-tyrosine kinase erbB-4	6.6	6.6	7.6	pIC50	2
Homo sapiens	Receptor protein-tyrosine kinase erbB-4	6.1	6.1	6.1	pKd	1
Homo sapiens	Rho-associated protein kinase 1	9	7.7	9.2	pIC50	4
Homo sapiens	Rho-associated protein kinase 1	9.6	9.6	9.6	pKd	1
Homo sapiens	Rho-associated protein kinase 2	8.1	8.1	8.1	pIC50	2
Homo sapiens	Rho-associated protein kinase 2	9.6	9.6	9.6	pKd	1
Homo sapiens	Rhodopsin kinase	9	9	9	pKd	1
Homo sapiens	Ribosomal protein S6 kinase 1	9	9	9	pIC50	1
Homo sapiens	Ribosomal protein S6 kinase 1	8.9	8.9	8.9	pKd	1
Homo sapiens	Ribosomal protein S6 kinase alpha 1	8.9	8.9	10.1	pIC50	4
Homo sapiens	Ribosomal protein S6 kinase alpha 1	5.9	5.9	7.4	pKd	8
Homo sapiens	Ribosomal protein S6 kinase alpha 2	8	6.7	8.1	pKd	10
Homo sapiens	Ribosomal protein S6 kinase alpha 3	7.2	7.2	7.2	pKd	6
Homo sapiens	Ribosomal protein S6 kinase alpha 4	5.7	5.7	6.9	pKd	8
Homo sapiens	Ribosomal protein S6 kinase alpha 5	8.9	8.9	8.9	pIC50	2
Homo sapiens	Ribosomal protein S6 kinase alpha 5	7.4	6.1	7.7	pKd	10
Homo sapiens	Ribosomal protein S6 kinase alpha 6	5.5	5.5	7.8	pKd	8
Homo sapiens	Serine/threonine-protein kinase 10	10.4	10.4	10.5	pKd	3
Homo sapiens	Serine/threonine-protein kinase 11	7.2	7.2	7.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase 16	6.6	6.6	6.7	pKd	3
Homo sapiens	Serine/threonine-protein kinase 17A	7.9	7.6	7.9	pKd	3
Homo sapiens	Serine/threonine-protein kinase 17B	7.6	7.6	7.6	pIC50	1
Homo sapiens	Serine/threonine-protein kinase 17B	7.7	7.6	7.7	pKd	3
Homo sapiens	Serine/threonine-protein kinase 2	10.6	10.6	10.7	pKd	3
Homo sapiens	Serine/threonine-protein kinase 24	6.9	6.9	6.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase 25	7	7	7	pKd	2
Homo sapiens	Serine/threonine-protein kinase 32A	7.9	7.9	7.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase 32B	7	7	7	pKd	2
Homo sapiens	Serine/threonine-protein kinase 32C	6.5	6.5	6.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase 33	8.7	8.7	8.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase 35	6.9	6.9	6.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase 36	5.2	5.2	5.5	pKd	3
Homo sapiens	Serine/threonine-protein kinase 38	7.3	7.3	7.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase 38-like	7.6	7.1	7.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase AKT	6.3	6.3	6.3	pEC50	2
Homo sapiens	Serine/threonine-protein kinase AKT	7.9	6.5	8.8	pIC50	20
Homo sapiens	Serine/threonine-protein kinase AKT	7.7	7.7	7.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase AKT2	8.1	7.8	8.2	pIC50	4
Homo sapiens	Serine/threonine-protein kinase AKT2	7.4	7.4	7.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase AKT3	8	8	9.2	pIC50	5
Homo sapiens	Serine/threonine-protein kinase AKT3	6.8	6.8	6.8	pKd	2
Homo sapiens	Serine/threonine-protein kinase Aurora-A	8	7.4	9.2	pIC50	14
Homo sapiens	Serine/threonine-protein kinase Aurora-A	7.8	7	7.8	pKd	3
Homo sapiens	Serine/threonine-protein kinase Aurora-B	8.7	8.1	9	pIC50	7
Homo sapiens	Serine/threonine-protein kinase Aurora-B	7.7	7.7	7.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase Aurora-C	7.6	7.6	8	pKd	3
Homo sapiens	Serine/threonine-protein kinase B-raf	8.3	7.9	8.4	pIC50	5
Homo sapiens	Serine/threonine-protein kinase Chk1	8.7	8	9.8	pIC50	6
Homo sapiens	Serine/threonine-protein kinase Chk1	8.5	8.5	8.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase Chk2	7.6	4.6	8.5	pIC50	7
Homo sapiens	Serine/threonine-protein kinase Chk2	7.1	7.1	7.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase c-TAK1	8.5	8.5	8.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase D2	7.1	7.1	7.1	pKd	2
Homo sapiens	Serine/threonine-protein kinase DCLK1	7	7	7	pKd	2
Homo sapiens	Serine/threonine-protein kinase DCLK2	7.1	7.1	7.1	pKd	2
Homo sapiens	Serine/threonine-protein kinase DCLK3	7.8	7.8	7.8	pKd	2
Homo sapiens	Serine/threonine-protein kinase GAK	7.8	7.2	7.8	pKd	3
Homo sapiens	Serine/threonine-protein kinase ICK	7.4	7.4	7.4	pIC50	1
Homo sapiens	Serine/threonine-protein kinase ICK	7.8	7.8	7.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase LATS1	7.4	7.4	7.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase LATS2	7.8	7.8	7.8	pKd	2
Homo sapiens	Serine/threonine-protein kinase MAK	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase MARK1	8.4	8.4	8.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase MRCK-A	7.2	7.2	7.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase MRCK beta	7.4	7.4	7.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase MRCK gamma	7.4	7.4	7.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase MST1	9.7	9.7	9.7	pKd	3
Homo sapiens	Serine/threonine-protein kinase MST2	8.3	8.3	9.4	pIC50	2
Homo sapiens	Serine/threonine-protein kinase MST2	9.7	9.7	9.7	pKd	2
Mus musculus	Serine/threonine-protein kinase MST2	9.8	9.8	9.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase MST4	6.9	6.9	6.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase Nek1	6.1	6.1	6.1	pKd	2
Homo sapiens	Serine/threonine-protein kinase Nek11	5.5	5.5	5.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase NEK2	5.3	5.3	5.3	pIC50	1
Homo sapiens	Serine/threonine-protein kinase NEK2	6.1	6.1	6.1	pKd	3
Homo sapiens	Serine/threonine-protein kinase Nek5	6.1	6.1	6.1	pKd	2
Homo sapiens	Serine/threonine-protein kinase NEK7	5.4	5.4	5.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase NEK9	5.5	5.2	5.5	pKd	3
Homo sapiens	Serine/threonine-protein kinase NIM1	6.9	6.9	6.9	pKd	1
Homo sapiens	Serine/threonine protein kinase NLK	6.7	6.7	6.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase OSR1	6.4	6.4	6.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase PAK 1	9.5	9.5	9.5	pIC50	1
Homo sapiens	Serine/threonine-protein kinase PAK 1	9.2	8.7	9.2	pKd	3
Homo sapiens	Serine/threonine-protein kinase PAK 2	8.6	8.6	9	pIC50	2
Homo sapiens	Serine/threonine-protein kinase PAK 2	8.5	8.5	8.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase PAK 3	8.2	8.2	9.3	pKd	3
Homo sapiens	Serine/threonine-protein kinase PAK 4	8.7	8.7	8.7	pIC50	1
Homo sapiens	Serine/threonine-protein kinase PAK 4	8.2	8.1	8.2	pKd	3
Homo sapiens	Serine/threonine-protein kinase PAK6	9.2	9.2	9.4	pKd	3
Homo sapiens	Serine/threonine-protein kinase PAK7	8.9	8.5	8.9	pKd	3
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-1	7.6	7.6	7.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-2	7	7	7	pKd	2
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-3	6.6	6.6	6.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase PFTAIRE-1	6.8	6.8	6.8	pKd	2
Homo sapiens	Serine/threonine-protein kinase PFTAIRE-2	6.6	6.6	6.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase PIM1	8	7	8.6	pIC50	11
Homo sapiens	Serine/threonine-protein kinase PIM1	8.5	7.8	8.9	pKd	4
Homo sapiens	Serine/threonine-protein kinase PIM2	7.6	6.5	8.2	pIC50	3
Homo sapiens	Serine/threonine-protein kinase PIM2	8.7	8.4	8.7	pKd	3
Homo sapiens	Serine/threonine-protein kinase PIM3	9.9	9.9	9.9	pIC50	1
Homo sapiens	Serine/threonine-protein kinase PIM3	9.3	9.3	9.3	pKd	2
Mycobacterium tuberculosis	Serine/threonine-protein kinase pknB	7.1	7.1	7.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK1	6.3	4.7	6.7	pIC50	5
Homo sapiens	Serine/threonine-protein kinase PLK1	6.7	6.7	6.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase PLK2	6.4	6	6.7	pIC50	3
Homo sapiens	Serine/threonine-protein kinase PLK2	6.7	6.7	6.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK3	6	6	6	pKd	2
Homo sapiens	Serine/threonine-protein kinase PLK4	9.1	9.1	9.1	pKd	3
Homo sapiens	Serine/threonine-protein kinase PRKX	7.9	7.9	7.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase PRP4 homolog	6.7	6.7	6.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase RAF	6.9	6.6	6.9	pIC50	3
Homo sapiens	Serine/threonine-protein kinase receptor R3	6.1	6.1	6.1	pIC50	1
Homo sapiens	Serine/threonine-protein kinase RIO1	6.9	6.9	6.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase RIO2	6.4	6.4	6.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIO3	7.1	7.1	7.1	pKd	2
Homo sapiens	Serine/threonine-protein kinase RIPK2	5.3	5.3	5.3	pKd	3
Homo sapiens	Serine/threonine-protein kinase SBK1	8.5	8.5	8.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase Sgk1	7.9	7.9	7.9	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Sgk3	8.5	8.5	8.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK1	8.7	8.7	8.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase SIK2	9	9	9	pKd	2
Homo sapiens	Serine/threonine-protein kinase SIK3	9.3	9.3	9.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase SRPK1	8.3	8.3	8.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase SRPK2	7.2	7.2	7.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase SRPK3	7.1	7.1	7.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO1	9.4	9.4	9.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO2	7.9	7.9	7.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO3	9.7	9.7	9.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase TBK1	9.1	9.1	9.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase TNNI3K	6	6	6	pKd	2
Homo sapiens	Serine/threonine-protein kinase tousled-like 1	7.6	7.6	7.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase tousled-like 2	7.8	7.8	7.8	pKd	2
Homo sapiens	Serine/threonine-protein kinase ULK1	8	8	8	pKd	1
Homo sapiens	Serine/threonine-protein kinase ULK2	9.1	9.1	9.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase ULK3	8.9	8.9	8.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase WEE1	5.8	5.8	5.8	pKd	2
Homo sapiens	SNF-related serine/threonine-protein kinase	7.1	7.1	7.1	pKd	1
Homo sapiens	SPS1/STE20-related protein kinase YSK4	9.1	9.1	9.1	pKd	1
Homo sapiens	STE20/SPS1-related proline-alanine-rich protein kinase	6.9	6.9	6.9	pKd	1
Homo sapiens	Stem cell growth factor receptor	7.6	7.1	8.4	pIC50	7
Homo sapiens	Stem cell growth factor receptor	7.8	7	9.4	pKd	16
Homo sapiens	Testis-specific serine/threonine-protein kinase 1	7.6	7.6	7.6	pKd	2
Mus musculus	Testis-specific serine/threonine-protein kinase 1	9.5	9.5	9.5	pIC50	1
Homo sapiens	TGF-beta receptor type I	5.2	5.2	5.2	pIC50	1
Homo sapiens	TGF-beta receptor type I	5.7	5.7	5.7	pKd	2
Homo sapiens	TRAF2- and NCK-interacting kinase	7.4	7.4	8.9	pIC50	2
Homo sapiens	TRAF2- and NCK-interacting kinase	8.3	8.2	8.3	pKd	3
Homo sapiens	Tyrosine kinase non-receptor protein 2	7.8	7.8	7.8	pKd	3
Homo sapiens	Tyrosine-protein kinase ABL	6.9	6.5	7.5	pIC50	9
Homo sapiens	Tyrosine-protein kinase ABL	7	5.6	8.5	pKd	29
Homo sapiens	Tyrosine-protein kinase ABL2	7.1	7.1	7.1	pIC50	1
Homo sapiens	Tyrosine-protein kinase ABL2	7	6.8	7	pKd	3
Homo sapiens	Tyrosine-protein kinase BLK	7.8	7.8	7.8	pKd	2
Mus musculus	Tyrosine-protein kinase BLK	6.4	6.4	6.4	pIC50	1
Homo sapiens	Tyrosine-protein kinase BMX	6.8	6.4	6.8	pKd	3
Homo sapiens	Tyrosine-protein kinase BRK	5.9	5.9	6.6	pIC50	2
Homo sapiens	Tyrosine-protein kinase BRK	5.6	5.6	5.6	pKd	2
Homo sapiens	Tyrosine-protein kinase BTK	7.4	4.8	7.9	pIC50	6
Homo sapiens	Tyrosine-protein kinase BTK	6.7	6.2	6.7	pKd	3
Homo sapiens	Tyrosine-protein kinase CSK	6.5	6.4	6.5	pKd	3
Homo sapiens	Tyrosine-protein kinase CTK	6.6	6.6	6.6	pKd	1
Homo sapiens	Tyrosine-protein kinase FER	8.7	8.7	8.7	pIC50	1
Homo sapiens	Tyrosine-protein kinase FER	7.6	7.5	7.6	pKd	3
Homo sapiens	Tyrosine-protein kinase FES	8.1	8.1	8.1	pIC50	1
Homo sapiens	Tyrosine-protein kinase FES	7.6	7.6	7.6	pKd	2
Homo sapiens	Tyrosine-protein kinase FGR	7.8	7.5	7.8	pKd	3
Homo sapiens	Tyrosine-protein kinase FRK	7.4	6.6	7.4	pKd	3
Homo sapiens	Tyrosine-protein kinase FYN	7.4	6.3	8.7	pIC50	8
Homo sapiens	Tyrosine-protein kinase FYN	7.5	7.3	7.5	pKd	3
Homo sapiens	Tyrosine-protein kinase HCK	7.7	7.7	7.9	pKd	3
Homo sapiens	Tyrosine-protein kinase ITK/TSK	7.9	4.8	8.4	pIC50	4
Homo sapiens	Tyrosine-protein kinase ITK/TSK	7.7	7.7	7.7	pKd	2
Homo sapiens	Tyrosine-protein kinase JAK1	8.5	7.9	9	pIC50	6
Homo sapiens	Tyrosine-protein kinase JAK1	8.2	8.2	8.2	pKd	2
Homo sapiens	Tyrosine-protein kinase JAK2	8.7	8.3	9.5	pIC50	12
Homo sapiens	Tyrosine-protein kinase JAK2	8	8	8	pKd	6
Homo sapiens	Tyrosine-protein kinase JAK3	9.3	8.2	10	pIC50	16
Homo sapiens	Tyrosine-protein kinase JAK3	7.9	7.9	8	pKd	4
Homo sapiens	Tyrosine-protein kinase LCK	8.6	5.7	9	pIC50	10
Homo sapiens	Tyrosine-protein kinase LCK	7.5	7.5	7.7	pKd	3
Homo sapiens	Tyrosine-protein kinase Lyn	8.9	8.7	9.3	pIC50	6
Homo sapiens	Tyrosine-protein kinase Lyn	7.4	6.7	7.4	pKd	3
Homo sapiens	Tyrosine-protein kinase receptor FLT3	8.9	8.3	9.7	pIC50	14
Homo sapiens	Tyrosine-protein kinase receptor FLT3	8.6	8.5	9.7	pKd	14
Homo sapiens	Tyrosine-protein kinase receptor RET	8.3	8.3	9.3	pIC50	4
Homo sapiens	Tyrosine-protein kinase receptor RET	7.8	7.6	7.9	pKd	6
Homo sapiens	Tyrosine-protein kinase receptor Tie-1	7.2	7.2	7.2	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	7.3	7.3	7.3	pIC50	1
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	6.6	6.6	6.6	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor UFO	7.4	7.4	8.5	pIC50	2
Homo sapiens	Tyrosine-protein kinase receptor UFO	8.2	8.2	8.2	pKd	2
Homo sapiens	Tyrosine-protein kinase SRC	8	5.5	9.1	pIC50	23
Homo sapiens	Tyrosine-protein kinase SRC	7.1	7	8.1	pKd	4
Homo sapiens	Tyrosine-protein kinase Srms	6.1	6.1	6.1	pKd	2
Homo sapiens	Tyrosine-protein kinase SYK	8.5	7.2	9.4	pIC50	6
Homo sapiens	Tyrosine-protein kinase SYK	7.9	7.9	8.2	pKd	3
Homo sapiens	Tyrosine-protein kinase TEC	5.9	5.9	5.9	pKd	2
Homo sapiens	Tyrosine-protein kinase TIE-2	7.3	6.7	7.3	pIC50	3
Homo sapiens	Tyrosine-protein kinase TIE-2	6.9	6.6	6.9	pKd	3
Homo sapiens	Tyrosine-protein kinase TXK	6.6	6.6	6.6	pKd	2
Homo sapiens	Tyrosine-protein kinase TYK2	9.2	9.2	9.5	pIC50	4
Homo sapiens	Tyrosine-protein kinase TYK2	7.3	5.5	7.3	pKd	6
Homo sapiens	Tyrosine-protein kinase YES	8.4	8.4	8.6	pIC50	2
Homo sapiens	Tyrosine-protein kinase YES	7.3	7.3	7.3	pKd	3
Homo sapiens	Tyrosine-protein kinase ZAP-70	7.9	7.3	8.9	pIC50	5
Homo sapiens	Tyrosine-protein kinase ZAP-70	7.4	7.4	7.4	pKd	2
Mus musculus	ULK3 kinase	8.5	8.5	8.5	pKd	1
Homo sapiens	Vascular endothelial growth factor receptor 1	7.8	7.5	8.3	pIC50	5
Homo sapiens	Vascular endothelial growth factor receptor 1	6.8	6.8	6.8	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 2	8	4.7	8.9	pIC50	26
Homo sapiens	Vascular endothelial growth factor receptor 2	6.7	6.6	6.7	pKd	3
Homo sapiens	Vascular endothelial growth factor receptor 2	8.8	8.8	8.8	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 3	8.5	7.2	9.1	pIC50	7
Homo sapiens	Vascular endothelial growth factor receptor 3	7.6	7.5	7.6	pKd	3

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 R
95

2 V
96

3 L
97

4 G
98

5 K
99

6 G
100

7 G
101

8 Y
102

9 G
103

10 K
104

11 V
105

12 F
106

13 Q
107

14 F
120

15 A
121

16 M
122

17 K
123

18 V
124

19 L
125

20 _
_

•

αC

b.l

21 _
_

22 _
_

23 _
_

24 _
_

25 _
_

26 _
_

27 _
_

28 _
_

29 _
_

30 _
_

31 _
_

32 _
_

33 P
153

34 F
154

35 I
155

36 V
156

37 D
157

38 L
158

39 I
159

40 Y
160

•

hinge

linker

αD

αE

41 A
161

42 Y
169

43 L
170

44 I
171

45 L
172

46 E
173

47 Y
174

48 L
175

49 S
176

50 G
177

51 G
178

52 E
179

53 L
180

54 F
181

55 M
182

56 Q
183

57 L
184

58 E
185

59 R
186

60 H
208

•

••

•

αE

c.l

VII

VIII

61 L
209

62 H
210

63 Q
211

64 K
212

65 G
213

66 I
214

67 I
215

68 Y
216

69 R
217

70 D
218

71 L
219

72 K
220

73 P
221

74 E
222

75 N
223

76 I
224

77 M
225

78 L
226

79 L
234

80 T
235

••

•

DFG

a.l

81 D
236

82 F
237

83 G
238

84 L
239

85 C
240

••

Interaction pattern search

Search KLIFS for kinase-ligand complexes with similar interaction patterns: