KLIFS - the kinase structures database

Version: 3.2
Updated: 29-Oct-2025

Kinase structure
Kinase:	FGFR1
Family:	FGFR
Group:	TK
Species:	HUMAN
IUPHAR/BPS ID:	1808
PDB:	5A46
sc-PDB:
KIDFamMap:	Search
Release date:	2015-08-05
PubMed:	26203596
Chain:	A
(Alternate) Model:	B
Orthosteric ligand:	38O

More entries for 5A46
5A46	Alternative model:	A	Chain:	A
5A46	Alternative model:	A	Chain:	B
5A46	Alternative model:	B	Chain:	B

Structural information
DFG conformation:	in
αC-helix conformation:	in
G-rich loop angle (distance):	64.4° (19.1Å)
G-rich loop rotation:	45.3°
Quality Score:	8.5
Resolution:	2.63 Å
Missing Residues:	0
Missing Atoms:	15

Ligand binding mode
Pockets	Subpockets	Waters
front		Cluster I1 I3 I10	Ligand No No No	Protein No No Yes

Pocket alignment
Uniprot sequence:	KPLGEGCFGQVVLVAVKMLDLISEMEMMKMIGKNIINLLGAYVIVEYASKGNLREYLQAYLASKKCIHRDLAARNVLVIADFGLA
Sequence structure:	KPLGEGCFGQVVLVAVKMLDLISEMEMMKMIGKNIINLLGAYVIVEYASKGNLREYLQAYLASKKCIHRDLAARNVLVIADFGLA

Ligand affinity
ChEMBL ID:	CHEMBL522892
Bioaffinities:	483 records for 197 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	3-phosphoinositide dependent protein kinase-1	6	6	6	pKi	1
Homo sapiens	Activin receptor type-1	5.9	5.9	5.9	pKi	1
Homo sapiens	Adaptor-associated kinase	6.8	6.8	6.8	pKd	2
Homo sapiens	ALK tyrosine kinase receptor	5.5	5.5	5.5	pKd	2
Homo sapiens	ALK tyrosine kinase receptor	6.2	6.2	6.2	pKi	1
Homo sapiens	AMP-activated protein kinase, alpha-1 subunit	6.3	6.3	6.3	pKd	2
Homo sapiens	AMP-activated protein kinase, alpha-1 subunit	7.1	7.1	7.1	pKi	1
Homo sapiens	AMP-activated protein kinase, alpha-2 subunit	6.1	6.1	6.1	pKd	2
Homo sapiens	Ankyrin repeat and protein kinase domain-containing protein 1	7.1	7.1	7.1	pKd	2
Homo sapiens	BMP-2-inducible protein kinase	7.3	7.3	7.3	pKd	2
Homo sapiens	Bone morphogenetic protein receptor type-2	5.5	5.5	5.5	pKd	2
Homo sapiens	BR serine/threonine-protein kinase 1	6.4	6.4	6.4	pKi	1
Plasmodium falciparum (isolate 3D7)	Calcium-dependent protein kinase 1	6.2	6.2	6.2	pKd	1
Homo sapiens	CaM kinase II delta	6.5	6.5	6.5	pKi	1
Homo sapiens	CaM kinase II gamma	6.1	6.1	6.1	pKi	1
Homo sapiens	CaM-kinase kinase alpha	5.5	5.5	5.5	pKd	2
Homo sapiens	CaM-kinase kinase beta	6.8	6.8	6.8	pKi	1
Homo sapiens	Casein kinase I delta	5.8	5.8	5.8	pKi	1
Homo sapiens	Casein kinase II alpha	5.6	5.6	5.9	pKd	2
Homo sapiens	Casein kinase II alpha (prime)	5.8	5.8	6.7	pKd	2
Homo sapiens	Citron Rho-interacting kinase	5.1	5.1	5.1	pKd	2
Homo sapiens	c-Jun N-terminal kinase 1	5.5	5.5	5.5	pKi	1
Homo sapiens	c-Jun N-terminal kinase 3	6.2	6.2	6.2	pKi	1
Homo sapiens	Cyclin-dependent kinase 4	5.5	5.5	5.9	pKd	2
Homo sapiens	Cyclin-dependent kinase 7	5.6	5.6	5.6	pKd	2
Homo sapiens	Cyclin-dependent kinase 7	6.6	6.6	6.6	pKi	1
Homo sapiens	Cyclin-dependent kinase-like 2	6.8	6.8	6.8	pKd	1
Homo sapiens	Death-associated protein kinase 3	5.7	5.7	5.7	pKd	1
Homo sapiens	Discoidin domain-containing receptor 2	5.1	5.1	5.1	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	6.3	6.3	6.3	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	6.9	6.9	6.9	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	6.5	6.5	6.5	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	6.8	6.8	6.8	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 5	7.5	7.5	7.5	pKd	1
Homo sapiens	Dual specificity protein kinase CLK2	5.8	5.8	5.8	pKd	2
Homo sapiens	Dual specificity protein kinase CLK2	6.1	6.1	6.1	pKi	1
Homo sapiens	Dual specificity protein kinase CLK4	5.2	5.2	5.2	pKd	2
Homo sapiens	Dual specificity protein kinase CLK4	7	7	7	pKi	1
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 2	5.2	5.2	5.2	pKd	1
Homo sapiens	Dual specificty protein kinase CLK1	5.2	5.2	5.2	pKd	2
Homo sapiens	Epidermal growth factor receptor erbB1	5.9	5.9	6	pKd	2
Homo sapiens	Epithelial discoidin domain-containing receptor 1	5.6	5.6	5.6	pKd	2
Homo sapiens	Eukaryotic translation initiation factor 2-alpha kinase 4	6.6	6.6	6.6	pKd	2
Homo sapiens	Fibroblast growth factor receptor 1	6.8	6.8	6.8	pEC50	1
Homo sapiens	Fibroblast growth factor receptor 1	8	8	8.1	pIC50	2
Homo sapiens	Fibroblast growth factor receptor 1	6.8	6.8	6.8	pKd	2
Homo sapiens	Fibroblast growth factor receptor 1	7.6	7.6	7.6	pKi	1
Homo sapiens	Fibroblast growth factor receptor 2	6.4	6.4	6.4	pKd	2
Homo sapiens	Fibroblast growth factor receptor 3	8.1	8.1	8.5	pIC50	2
Homo sapiens	Fibroblast growth factor receptor 3	6.4	6.4	6.6	pKd	4
Homo sapiens	Fibroblast growth factor receptor 3	7.4	7.4	7.4	pKi	1
Homo sapiens	Fibroblast growth factor receptor 4	5.4	5.4	5.4	pKd	2
Homo sapiens	Glycogen synthase kinase-3 beta	6.5	6.5	6.5	pKd	2
Homo sapiens	G protein-coupled receptor kinase 4	7	7	7	pKd	1
Homo sapiens	G protein-coupled receptor kinase 7	5.9	5.9	5.9	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 1	5.4	5.4	5.4	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 2	6.3	6.3	6.3	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 3	5.3	5.3	5.3	pKd	1
Homo sapiens	Hormonally up-regulated neu tumor-associated kinase	6.4	6.4	6.4	pKd	1
Homo sapiens	Inhibitor of nuclear factor kappa B kinase alpha subunit	5.8	5.8	5.8	pKd	1
Homo sapiens	Inhibitor of nuclear factor kappa B kinase epsilon subunit	6.3	6.3	6.3	pKd	2
Homo sapiens	Inhibitor of nuclear factor kappa B kinase epsilon subunit	6.1	6.1	6.1	pKi	1
Homo sapiens	Insulin receptor	5.8	5.8	5.8	pKi	1
Homo sapiens	Interferon-induced, double-stranded RNA-activated protein kinase	5.6	5.6	5.6	pKd	2
Homo sapiens	Interleukin-1 receptor-associated kinase 1	6.8	6.8	6.8	pKd	1
Homo sapiens	Interleukin-1 receptor-associated kinase 1	5.9	5.9	5.9	pKi	1
Homo sapiens	Interleukin-1 receptor-associated kinase 4	6.9	6.9	6.9	pKd	1
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	5.8	5.8	6.1	pKd	2
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	6.5	6.5	6.5	pKi	1
Homo sapiens	LIM domain kinase 1	5.7	5.7	5.7	pKi	1
Homo sapiens	Macrophage colony stimulating factor receptor	8.5	8.5	9	pIC50	2
Homo sapiens	Macrophage colony stimulating factor receptor	7.2	7.2	7.2	pKd	2
Homo sapiens	Macrophage colony stimulating factor receptor	7.4	7.4	7.4	pKi	1
Homo sapiens	Macrophage-stimulating protein receptor	7.6	7.6	7.6	pKi	1
Homo sapiens	MAP/microtubule affinity-regulating kinase 2	5.8	5.8	5.8	pKd	2
Homo sapiens	MAP/microtubule affinity-regulating kinase 2	6.9	6.9	6.9	pKi	1
Homo sapiens	MAP/microtubule affinity-regulating kinase 4	5.8	5.8	5.8	pKd	2
Homo sapiens	MAP/microtubule affinity-regulating kinase 4	7	7	7	pKi	1
Homo sapiens	Maternal embryonic leucine zipper kinase	5.8	5.8	5.8	pKd	2
Homo sapiens	Maternal embryonic leucine zipper kinase	7.5	7.5	7.5	pKi	1
Homo sapiens	Microtubule-associated serine/threonine-protein kinase 1	7.4	7.4	7.4	pKd	1
Homo sapiens	Misshapen-like kinase 1	8	8	8	pKd	1
Homo sapiens	Misshapen-like kinase 1	8	8	8	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 10	5.8	5.8	5.8	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 11	5.7	5.7	5.7	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 12	5.7	5.7	5.7	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 13	6.8	6.8	6.8	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 2	7.2	7.2	7.2	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 4	5.3	5.3	5.3	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 7	6.2	6.2	6.2	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 9	5	5	5	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 1	7.4	7.4	7.4	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	5.7	5.7	5.7	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	6.2	6.2	6.2	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 3	6.3	6.3	6.3	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 4	6.8	6.8	6.8	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 4	7.6	7.6	7.6	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	6.2	6.2	6.2	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	7.5	7.5	7.5	pKi	1
Homo sapiens	Mixed lineage kinase 7	5.1	5.1	5.1	pKi	1
Homo sapiens	Muscle, skeletal receptor tyrosine protein kinase	6.1	6.1	6.1	pKd	2
Homo sapiens	Myosin light chain kinase	8.7	8.7	8.7	pKd	1
Homo sapiens	myosin light chain kinase 2	7	7	7	pKd	2
Homo sapiens	Myosin light chain kinase family member 4	7.1	7.1	7.1	pKd	2
Gallus gallus	Myosin light chain kinase, smooth muscle	8.7	8.7	8.7	pKd	1
Homo sapiens	Myosin light chain kinase, smooth muscle	5.5	5.5	5.5	pKd	2
Homo sapiens	Nerve growth factor receptor Trk-A	7	7	7	pKd	2
Homo sapiens	Nerve growth factor receptor Trk-A	6.6	6.6	6.6	pKi	1
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	6.1	6.1	6.1	pKd	2
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	7	7	7	pKi	1
Homo sapiens	NT-3 growth factor receptor	6.7	6.7	6.7	pKd	2
Homo sapiens	NT-3 growth factor receptor	6.7	6.7	6.7	pKi	1
Homo sapiens	NUAK family SNF1-like kinase 1	6.6	6.6	6.6	pKd	2
Homo sapiens	NUAK family SNF1-like kinase 2	6.9	6.9	6.9	pKd	2
Homo sapiens	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha	5.7	5.7	5.7	pKd	2
Homo sapiens	Phosphatidylinositol-5-phosphate 4-kinase type-2 beta	6.6	6.6	6.6	pKd	2
Homo sapiens	Phosphorylase kinase gamma subunit 1	6.2	6.2	6.2	pKd	2
Homo sapiens	Phosphorylase kinase gamma subunit 2	5.1	5.1	5.1	pKd	2
Homo sapiens	Phosphorylase kinase gamma subunit 2	6	6	6	pKi	1
Homo sapiens	Platelet-derived growth factor receptor alpha	7.3	7.3	7.3	pKd	2
Homo sapiens	Platelet-derived growth factor receptor alpha	6.6	6.6	6.6	pKi	1
Homo sapiens	Platelet-derived growth factor receptor beta	7.3	7.3	7.3	pEC50	1
Homo sapiens	Platelet-derived growth factor receptor beta	8.3	8.3	9	pIC50	2
Homo sapiens	Platelet-derived growth factor receptor beta	8.4	8.4	8.4	pKd	2
Homo sapiens	Platelet-derived growth factor receptor beta	8.2	8.2	8.2	pKi	1
Homo sapiens	Protein kinase C delta	5.7	5.7	5.7	pKi	1
Homo sapiens	Protein kinase C nu	5.9	5.9	5.9	pKi	1
Homo sapiens	Protein kinase C theta	5.5	5.5	5.5	pKd	2
Homo sapiens	Protein kinase N1	6.8	6.8	6.8	pKd	2
Homo sapiens	Protein kinase N2	5	5	5	pKd	2
Homo sapiens	Protein kinase N2	6.2	6.2	6.2	pKi	1
Homo sapiens	Proto-oncogene tyrosine-protein kinase MER	5.8	5.8	5.8	pKd	2
Homo sapiens	Receptor-interacting serine/threonine-protein kinase 1	6.5	6.5	6.5	pKd	2
Homo sapiens	Rho-associated protein kinase 1	6.1	6.1	6.1	pKd	1
Homo sapiens	Rho-associated protein kinase 2	5.5	5.5	5.5	pKd	1
Homo sapiens	Rho-associated protein kinase 2	5.4	5.4	5.4	pKi	1
Homo sapiens	Rhodopsin kinase	5.7	5.7	5.7	pKd	1
Homo sapiens	Ribosomal protein S6 kinase 1	6.2	6.2	6.2	pKd	1
Homo sapiens	Ribosomal protein S6 kinase 1	7	7	7	pKi	1
Homo sapiens	Ribosomal protein S6 kinase alpha 1	6.4	6.4	6.4	pKd	4
Homo sapiens	Ribosomal protein S6 kinase alpha 2	6.5	6.5	6.5	pKd	4
Homo sapiens	Ribosomal protein S6 kinase alpha 3	5.3	5.3	5.3	pKd	4
Homo sapiens	Ribosomal protein S6 kinase alpha 3	6.5	6.5	6.5	pKi	2
Homo sapiens	Ribosomal protein S6 kinase alpha 4	6.2	6.2	6.2	pKd	4
Homo sapiens	Ribosomal protein S6 kinase alpha 5	6.2	6.2	6.2	pKd	4
Homo sapiens	Ribosomal protein S6 kinase alpha 5	6	6	6	pKi	2
Homo sapiens	Ribosomal protein S6 kinase alpha 6	5.3	5.3	5.3	pKd	4
Homo sapiens	Serine/threonine-protein kinase 10	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase 11	5.4	5.4	5.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase 16	5.8	5.8	5.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase 17A	6.1	6.1	6.1	pKd	2
Homo sapiens	Serine/threonine-protein kinase 17B	5.8	5.8	5.8	pKd	2
Homo sapiens	Serine/threonine-protein kinase 2	6.5	6.5	6.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase 2	6.7	6.7	6.7	pKi	1
Homo sapiens	Serine/threonine-protein kinase 24	6.4	6.4	6.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase 25	5.9	5.9	5.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase 38	6.2	6.2	6.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase Aurora-B	6.6	6.6	6.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase Aurora-B	7.1	7.1	7.1	pKi	1
Homo sapiens	Serine/threonine-protein kinase Aurora-C	6	6	6	pKd	2
Homo sapiens	Serine/threonine-protein kinase Chk1	5.9	5.9	5.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase Chk1	6.8	6.8	6.8	pKi	1
Homo sapiens	Serine/threonine-protein kinase Chk2	5.8	5.8	5.8	pKi	1
Homo sapiens	Serine/threonine-protein kinase c-TAK1	5.5	5.5	5.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase c-TAK1	6.9	6.9	6.9	pKi	1
Homo sapiens	Serine/threonine-protein kinase D2	5.7	5.7	5.7	pKi	1
Homo sapiens	Serine/threonine-protein kinase DCLK3	5.9	5.9	5.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase GAK	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase LATS1	5.8	5.8	5.8	pKd	2
Homo sapiens	Serine/threonine-protein kinase LATS2	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase MARK1	5.6	5.6	5.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase MST1	6.7	6.7	6.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase MST2	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase MST2	6.7	6.7	6.7	pKi	1
Homo sapiens	Serine/threonine-protein kinase MST4	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase NEK2	5.7	5.7	5.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase NEK2	6.3	6.3	6.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase Nek4	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase Nek4	5.3	5.3	5.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase Nek5	5.6	5.6	5.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase NEK6	5.8	5.8	5.8	pKd	2
Homo sapiens	Serine/threonine-protein kinase NEK7	5.3	5.3	5.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase NEK9	5	5	5	pKd	2
Homo sapiens	Serine/threonine-protein kinase NIM1	6.1	6.1	6.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase PAK 3	6.1	6.1	6.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase PAK 4	5.7	5.7	5.7	pKi	1
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-1	6.4	6.4	6.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-2	5.5	5.5	5.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-3	5.1	5.1	5.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase PIM2	5.9	5.9	5.9	pKi	1
Mycobacterium tuberculosis	Serine/threonine-protein kinase pknB	6.5	6.5	6.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK2	6.2	6.2	6.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK4	5.9	5.9	5.9	pKi	1
Homo sapiens	Serine/threonine-protein kinase PRKX	5.8	5.8	5.8	pKi	1
Homo sapiens	Serine/threonine-protein kinase PRP4 homolog	6.3	6.3	6.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIO1	6.4	6.4	6.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase RIO2	6.6	6.6	6.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIO3	6.2	6.2	6.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase SBK1	5.8	5.8	5.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase Sgk2	5.9	5.9	5.9	pKi	1
Homo sapiens	Serine/threonine-protein kinase Sgk3	6	6	6	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK2	5.4	5.4	5.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase SIK2	7	7	7	pKi	1
Homo sapiens	Serine/threonine-protein kinase SRPK1	6.4	6.4	6.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase SRPK1	5.3	5.3	5.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase SRPK2	6.5	6.5	6.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase SRPK3	6.6	6.6	6.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase TBK1	6.9	6.9	6.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase tousled-like 2	5.6	5.6	5.6	pKd	2
Homo sapiens	Serine/threonine-protein kinase ULK1	7.3	7.3	7.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase ULK2	7.3	7.3	7.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase ULK3	6.8	6.8	6.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase WEE1	5.9	5.9	5.9	pKd	2
Homo sapiens	SPS1/STE20-related protein kinase YSK4	7.9	7.9	7.9	pKd	1
Homo sapiens	STE20/SPS1-related proline-alanine-rich protein kinase	6.3	6.3	6.3	pKd	1
Homo sapiens	Stem cell growth factor receptor	8.5	7.3	9	pIC50	4
Homo sapiens	Stem cell growth factor receptor	8.1	5.9	8.8	pKd	15
Homo sapiens	Stem cell growth factor receptor	7.7	7.7	7.7	pKi	1
Homo sapiens	Testis-specific serine/threonine-protein kinase 1	6.3	6.3	6.3	pKi	1
Homo sapiens	TRAF2- and NCK-interacting kinase	8.1	7.2	8.7	pIC50	3
Homo sapiens	TRAF2- and NCK-interacting kinase	7.6	7.6	7.6	pKd	3
Homo sapiens	Tyrosine-protein kinase ABL	6.4	6.4	6.6	pIC50	2
Homo sapiens	Tyrosine-protein kinase ABL	7	5.2	7.5	pKd	21
Homo sapiens	Tyrosine-protein kinase ABL	7	7	7	pKi	1
Homo sapiens	Tyrosine-protein kinase BLK	6.7	6.7	6.7	pKd	2
Homo sapiens	Tyrosine-protein kinase BLK	7.9	7.9	7.9	pKi	1
Homo sapiens	Tyrosine-protein kinase BTK	5.7	5.7	5.7	pKi	1
Homo sapiens	Tyrosine-protein kinase FGR	6.7	6.7	6.7	pKd	2
Homo sapiens	Tyrosine-protein kinase FRK	5.6	5.6	5.6	pKd	2
Homo sapiens	Tyrosine-protein kinase FYN	6.4	6.4	6.4	pKd	2
Homo sapiens	Tyrosine-protein kinase FYN	7.2	7.2	7.2	pKi	1
Homo sapiens	Tyrosine-protein kinase HCK	5.5	5.5	5.5	pKd	2
Homo sapiens	Tyrosine-protein kinase HCK	6.8	6.8	6.8	pKi	1
Homo sapiens	Tyrosine-protein kinase ITK/TSK	6.3	6.3	6.3	pKd	2
Homo sapiens	Tyrosine-protein kinase ITK/TSK	7.3	7.3	7.3	pKi	1
Homo sapiens	Tyrosine-protein kinase JAK1	6.4	6.4	6.4	pKd	4
Homo sapiens	Tyrosine-protein kinase JAK2	5.2	5.2	6.9	pKd	4
Homo sapiens	Tyrosine-protein kinase JAK2	6	6	6	pKi	2
Homo sapiens	Tyrosine-protein kinase JAK3	5.1	5.1	6.4	pKd	4
Homo sapiens	Tyrosine-protein kinase LCK	6.6	6.6	6.6	pKd	2
Homo sapiens	Tyrosine-protein kinase LCK	7.7	7.7	7.7	pKi	1
Homo sapiens	Tyrosine-protein kinase Lyn	6.1	6.1	6.1	pKd	2
Homo sapiens	Tyrosine-protein kinase Lyn	7.2	7.2	7.2	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor FLT3	8.5	8.5	9	pIC50	2
Homo sapiens	Tyrosine-protein kinase receptor FLT3	8.3	8.1	9.2	pKd	12
Homo sapiens	Tyrosine-protein kinase receptor FLT3	8.5	8.5	8.5	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor RET	7.3	7.2	7.6	pKd	6
Homo sapiens	Tyrosine-protein kinase receptor RET	8.3	8.3	8.3	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor Tie-1	5.4	5.4	5.4	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	5	5	5	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	7.3	7.3	7.3	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor UFO	5.4	5.4	5.4	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor UFO	6.6	6.6	6.6	pKi	1
Gallus gallus	Tyrosine-protein kinase SRC	7.1	7.1	7.1	pIC50	1
Homo sapiens	Tyrosine-protein kinase SRC	5.8	5.8	5.8	pKd	2
Homo sapiens	Tyrosine-protein kinase SRC	7.2	7.2	7.2	pKi	1
Homo sapiens	Tyrosine-protein kinase TYK2	5.7	5.7	6.8	pKd	4
Homo sapiens	Tyrosine-protein kinase TYK2	6.7	6.7	6.7	pKi	2
Homo sapiens	Tyrosine-protein kinase YES	7.5	7.5	8.9	pIC50	2
Homo sapiens	Tyrosine-protein kinase YES	6.2	6.2	6.2	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 1	8	8	8.5	pIC50	2
Homo sapiens	Vascular endothelial growth factor receptor 1	7.2	7.2	7.2	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 1	7.4	7.4	7.4	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 2	7.3	7.3	7.3	pEC50	1
Homo sapiens	Vascular endothelial growth factor receptor 2	7.2	7.2	7.9	pIC50	2
Homo sapiens	Vascular endothelial growth factor receptor 2	7.2	7.2	7.2	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 2	7.7	7.7	7.7	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 3	8.5	8.1	8.6	pIC50	3
Homo sapiens	Vascular endothelial growth factor receptor 3	6.2	6.2	6.2	pKd	2
Homo sapiens	Vascular endothelial growth factor receptor 3	7	7	7	pKi	1

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 K
482

2 P
483

3 L
484

4 G
485

5 E
486

6 G
487

7 C
488

8 F
489

9 G
490

10 Q
491

11 V
492

12 V
493

13 L
494

14 V
511

15 A
512

16 V
513

17 K
514

18 M
515

19 L
516

20 D
527

•

αC

b.l

21 L
528

22 I
529

23 S
530

24 E
531

25 M
532

26 E
533

27 M
534

28 M
535

29 K
536

30 M
537

31 I
538

32 G
539

33 K
542

34 N
543

35 I
544

36 I
545

37 N
546

38 L
547

39 L
548

40 G
549

•

hinge

linker

αD

αE

41 A
550

42 Y
558

43 V
559

44 I
560

45 V
561

46 E
562

47 Y
563

48 A
564

49 S
565

50 K
566

51 G
567

52 N
568

53 L
569

54 R
570

55 E
571

56 Y
572

57 L
573

58 Q
574

59 A
575

60 Y
613

•

•••

•

αE

c.l

VII

VIII

61 L
614

62 A
615

63 S
616

64 K
617

65 K
618

66 C
619

67 I
620

68 H
621

69 R
622

70 D
623

71 L
624

72 A
625

73 A
626

74 R
627

75 N
628

76 V
629

77 L
630

78 V
631

79 I
639

80 A
640

•

DFG

a.l

81 D
641

82 F
642

83 G
643

84 L
644

85 A
645

Interaction pattern search

Search KLIFS for kinase-ligand complexes with similar interaction patterns: