PDB-code
| Kinase structure | |
| Kinase: | FGFR2 |
| Family: | FGFR |
| Group: | TK |
| Species: | HUMAN |
| IUPHAR/BPS ID: | 1809 |
| PDB: | 3CLY |
| sc-PDB: | |
| KIDFamMap: | Search |
| Release date: | 2009-02-03 |
| PubMed: | 19060208 |
| Chain: | A |
| Orthosteric ligand: | ACP |
 | |
| Structural information | |
| DFG conformation: | in |
| αC-helix conformation: | in |
| G-rich loop angle (distance): | 57.7° (17.1Å) |
| G-rich loop rotation: | 68.4° |
| Quality Score: | 8 |
| Resolution: | 2 Å |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| Ligand binding mode | ||||
| Pockets | Subpockets | Waters | ||
| front | FP-II | Cluster I1 I4 I5 I7 I11 | Ligand Yes No No Yes Yes | Protein Yes Yes Yes No No |
| Pocket alignment | |
| Uniprot sequence: | KPLGEGCFGQVVMVAVKMLDLVSEMEMMKMIGKNIINLLGAYVIVEYASKGNLREYLRAYLASQKCIHRDLAARNVLVIADFGLA |
| Sequence structure: | KPLGEGAFGQVVMVAVKMLDLVSEMEMMKMIGKNIINLLGAYVIVEYASKGNLREYLRAYLASQKCIHRDLAARNVLVIADFGLA |
| Ligand affinity | |
| ChEMBL ID: | CHEMBL133463 |
| Bioaffinities: | No (p)Ki/(p)IC50/(p)EC50 values for kinases found (confidence ≥ 8). |
Kinase-ligand interaction pattern
• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 K 1485 | 2 P 1486 | 3 L 1487 | 4 G 1488 | 5 E 1489 | 6 G 1490 | 7 A 1491 | 8 F 1492 | 9 G 1493 | 10 Q 1494 | 11 V 1495 | 12 V 1496 | 13 M 1497 | 14 V 1514 | 15 A 1515 | 16 V 1516 | 17 K 1517 | 18 M 1518 | 19 L 1519 | 20 D 1530 |
| • | • | • | • | • | • | • | |||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 L 1531 | 22 V 1532 | 23 S 1533 | 24 E 1534 | 25 M 1535 | 26 E 1536 | 27 M 1537 | 28 M 1538 | 29 K 1539 | 30 M 1540 | 31 I 1541 | 32 G 1542 | 33 K 1545 | 34 N 1546 | 35 I 1547 | 36 I 1548 | 37 N 1549 | 38 L 1550 | 39 L 1551 | 40 G 1552 |
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 A 1553 | 42 Y 1561 | 43 V 1562 | 44 I 1563 | 45 V 1564 | 46 E 1565 | 47 Y 1566 | 48 A 1567 | 49 S 1568 | 50 K 1569 | 51 G 1570 | 52 N 1571 | 53 L 1572 | 54 R 1573 | 55 E 1574 | 56 Y 1575 | 57 L 1576 | 58 R 1577 | 59 A 1578 | 60 Y 1616 |
| • | •• | •• | •• | ||||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 1617 | 62 A 1618 | 63 S 1619 | 64 Q 1620 | 65 K 1621 | 66 C 1622 | 67 I 1623 | 68 H 1624 | 69 R 1625 | 70 D 1626 | 71 L 1627 | 72 A 1628 | 73 A 1629 | 74 R 1630 | 75 N 1631 | 76 V 1632 | 77 L 1633 | 78 V 1634 | 79 I 1642 | 80 A 1643 |
| • | • | ||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 1644 | 82 F 1645 | 83 G 1646 | 84 L 1647 | 85 A 1648 | |||||||||||||||
| • | |||||||||||||||||||
Interaction pattern search
Search KLIFS for kinase-ligand complexes with similar interaction patterns:
