KLIFS - the kinase structures database

Version: 3.2
Updated: 29-Oct-2025

Kinase structure
Kinase:	AURKA (AurA)
Family:	Aur
Group:	Other
Species:	HUMAN
IUPHAR/BPS ID:	1936
PDB:	5DR6
sc-PDB:
KIDFamMap:	Search
Release date:	2016-07-20
PubMed:	27339427
Chain:	A
(Alternate) Model:	A
Orthosteric ligand:	SKE

More entries for 5DR6
5DR6	Alternative model:	B	Chain:	A

Structural information
DFG conformation:	in
αC-helix conformation:	in
G-rich loop angle (distance):	61.5° (18Å)
G-rich loop rotation:	56.6°
Quality Score:	8
Resolution:	2.53 Å
Missing Residues:	0
Missing Atoms:	0

Ligand binding mode
Pockets	Subpockets
front	FP-I

Allosteric Ligand
Allosteric ligand:	5E1

Pocket alignment
Uniprot sequence:	RPLGKGKFGNVYLLALKVLQLRREVEIQSHLRPNILRLYGYYLILEYAPLGTVYRELQKYCHSKRVIHRDIKPENLLLIADFGWS
Sequence structure:	RPLGKGKFGNVYLLALKVLQLRREVEIQSHLRPNILRLYGYYLILEYAPLGTVYRELQKYCHSKRVIHRDIKPENLLLIADFGWS

Ligand affinity
ChEMBL ID:	CHEMBL191003
Bioaffinities:	243 records for 154 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	3-phosphoinositide dependent protein kinase-1	5.5	5.5	5.5	pKd	1
Homo sapiens	Activin receptor type-1	5.2	5.2	5.2	pKd	1
Homo sapiens	Activin receptor type-1	5.5	5.5	5.5	pKi	1
Homo sapiens	Activin receptor type-2A	5.5	5.5	5.5	pKd	1
Homo sapiens	Activin receptor type-2B	5.2	5.2	5.2	pKd	1
Homo sapiens	Adaptor-associated kinase	6.7	6.7	6.7	pKd	1
Homo sapiens	ALK tyrosine kinase receptor	5.2	5.2	5.2	pKd	1
Homo sapiens	ALK tyrosine kinase receptor	5.9	5.9	5.9	pKi	1
Homo sapiens	AMP-activated protein kinase, alpha-1 subunit	5.8	5.8	5.8	pKd	1
Homo sapiens	AMP-activated protein kinase, alpha-1 subunit	6.3	6.3	6.3	pKi	1
Homo sapiens	AMP-activated protein kinase, alpha-2 subunit	5.8	5.8	5.8	pKd	1
Homo sapiens	Ankyrin repeat and protein kinase domain-containing protein 1	6.3	6.3	6.3	pKd	1
Homo sapiens	BMP-2-inducible protein kinase	6.8	6.8	6.8	pKd	1
Homo sapiens	Bone morphogenetic protein receptor type-2	6.1	6.1	6.1	pKd	1
Homo sapiens	BR serine/threonine-protein kinase 1	5.2	5.2	5.2	pKd	1
Homo sapiens	BR serine/threonine-protein kinase 2	5.6	5.6	5.6	pKd	1
Homo sapiens	CaM-kinase kinase alpha	5.5	5.5	5.5	pKd	1
Homo sapiens	CaM-kinase kinase beta	5.6	5.6	5.6	pKd	1
Homo sapiens	CaM-kinase kinase beta	7.2	7.2	7.2	pKi	1
Homo sapiens	Casein kinase I epsilon	5.4	5.4	5.4	pKd	1
Homo sapiens	Casein kinase I gamma 1	5.9	5.9	5.9	pKd	1
Homo sapiens	Casein kinase I gamma 2	6.1	6.1	6.1	pKd	1
Homo sapiens	Casein kinase II alpha (prime)	5.7	5.7	5.7	pKd	1
Homo sapiens	Casein kinase I isoform gamma-3	5.1	5.1	5.1	pKd	1
Homo sapiens	Chaperone activity of bc1 complex-like, mitochondrial	5.9	5.9	5.9	pKd	1
Homo sapiens	c-Jun N-terminal kinase 1	5.8	5.8	5.8	pKd	1
Homo sapiens	c-Jun N-terminal kinase 1	6.2	6.2	6.2	pKi	1
Homo sapiens	c-Jun N-terminal kinase 3	5.9	5.9	5.9	pKd	1
Homo sapiens	c-Jun N-terminal kinase 3	6.5	6.5	6.5	pKi	1
Homo sapiens	Cyclin-dependent kinase 1	8.2	8.2	8.2	pIC50	1
Homo sapiens	Cyclin-dependent kinase 2	8.7	8.7	8.7	pIC50	1
Homo sapiens	Cyclin-dependent kinase 2	7.6	7.6	7.6	pKd	1
Homo sapiens	Cyclin-dependent kinase 3	6.8	6.8	6.8	pKd	1
Homo sapiens	Cyclin-dependent kinase 5	7.9	7.9	7.9	pIC50	1
Homo sapiens	Cyclin-dependent kinase 5	6.6	6.6	6.6	pKd	1
Homo sapiens	Cyclin-dependent kinase 5	9.3	9.3	9.3	pKi	1
Homo sapiens	Cyclin-dependent kinase 7	6.1	6.1	6.1	pKd	1
Homo sapiens	Cyclin-dependent kinase 7	6.2	6.2	6.2	pKi	1
Homo sapiens	Cyclin-dependent kinase 9	6.3	6.3	6.3	pKd	1
Homo sapiens	Cyclin-dependent kinase 9	7.8	7.8	7.8	pKi	1
Homo sapiens	Death-associated protein kinase 3	5.3	5.3	5.3	pKd	1
Homo sapiens	Death-associated protein kinase 3	5.7	5.7	5.7	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	5.8	5.8	5.8	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	5.7	5.7	5.7	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	5.3	5.3	5.3	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	5.4	5.4	5.4	pKi	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 3	5.8	5.8	5.8	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 4	6.2	6.2	6.2	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 6	6	6	6	pKd	1
Homo sapiens	Dual specificity protein kinase CLK2	6.5	6.5	6.5	pKd	1
Homo sapiens	Dual specificity protein kinase CLK2	6.2	6.2	6.2	pKi	1
Homo sapiens	Dual specificity protein kinase CLK3	6.5	6.5	6.5	pKd	1
Homo sapiens	Dual specificity protein kinase CLK4	5.8	5.8	5.8	pKd	1
Homo sapiens	Dual specificity protein kinase CLK4	6.7	6.7	6.7	pKi	1
Homo sapiens	Dual specificity protein kinase TTK	6.7	6.7	6.7	pKd	1
Homo sapiens	Dual specificity testis-specific protein kinase 1	5.5	5.5	5.5	pKd	1
Homo sapiens	Dual specificty protein kinase CLK1	6.2	6.2	6.2	pKd	1
Homo sapiens	Ephrin type-A receptor 7	5.5	5.5	5.5	pKd	1
Homo sapiens	Eukaryotic translation initiation factor 2-alpha kinase 4	5.4	5.4	5.4	pKd	1
Homo sapiens	Fibroblast growth factor receptor 1	6.1	6.1	6.1	pKd	1
Homo sapiens	Fibroblast growth factor receptor 1	6.5	6.5	6.5	pKi	1
Homo sapiens	Fibroblast growth factor receptor 2	6.7	6.7	6.7	pIC50	1
Homo sapiens	Fibroblast growth factor receptor 2	6.2	6.2	6.2	pKd	1
Homo sapiens	Fibroblast growth factor receptor 3	6.2	6.2	6.3	pKd	2
Homo sapiens	Glycogen synthase kinase-3 alpha	6.8	6.8	6.8	pKd	1
Homo sapiens	Glycogen synthase kinase-3 alpha	6.8	6.8	6.8	pKi	1
Homo sapiens	Glycogen synthase kinase-3 beta	6	6	6	pKd	1
Homo sapiens	Glycogen synthase kinase-3 beta	6.8	6.8	6.8	pKi	1
Homo sapiens	G protein-coupled receptor kinase 5	6	6	6	pKi	1
Homo sapiens	Hepatocyte growth factor receptor	6.2	6.2	6.2	pKd	1
Homo sapiens	Hepatocyte growth factor receptor	6.4	6.4	6.4	pKi	1
Homo sapiens	Inhibitor of nuclear factor kappa B kinase epsilon subunit	5.1	5.1	5.1	pKd	1
Homo sapiens	Interferon-induced, double-stranded RNA-activated protein kinase	5.2	5.2	5.2	pKd	1
Homo sapiens	Interleukin-1 receptor-associated kinase 3	5.5	5.5	5.5	pKd	1
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	7.1	7.1	7.1	pKi	1
Homo sapiens	LIM domain kinase 1	6.2	6.2	6.2	pKd	1
Homo sapiens	LIM domain kinase 1	6.7	6.7	6.7	pKi	1
Homo sapiens	LIM domain kinase 2	6	6	6	pKd	1
Homo sapiens	Macrophage colony stimulating factor receptor	5.4	5.4	5.4	pKd	1
Homo sapiens	Macrophage colony stimulating factor receptor	5.9	5.9	5.9	pKi	1
Homo sapiens	Macrophage-stimulating protein receptor	7	7	7	pKi	1
Homo sapiens	MAP/microtubule affinity-regulating kinase 2	5.9	5.9	5.9	pKd	1
Homo sapiens	MAP/microtubule affinity-regulating kinase 4	6.2	6.2	6.2	pKd	1
Homo sapiens	MAP/microtubule affinity-regulating kinase 4	7	7	7	pKi	1
Homo sapiens	Maternal embryonic leucine zipper kinase	6.2	6.2	6.2	pKi	1
Homo sapiens	Mitogen-activated protein kinase 15	6	6	6	pKd	1
Homo sapiens	Mitogen-activated protein kinase 4	5.8	5.8	5.8	pKd	1
Homo sapiens	Mitogen-activated protein kinase 6	6.3	6.3	6.3	pKd	1
Homo sapiens	Mitogen-activated protein kinase 7	6.3	6.3	6.3	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 9	5.4	5.4	5.4	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 1	6.9	6.9	6.9	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	5.8	5.8	5.8	pKi	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 3	6.1	6.1	6.1	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	5.7	5.7	5.7	pKd	1
Homo sapiens	Myosin light chain kinase, smooth muscle	5.7	5.7	5.7	pKd	1
Homo sapiens	Myotonin-protein kinase	5.9	5.9	5.9	pKd	1
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	5.7	5.7	5.7	pKi	1
Homo sapiens	NUAK family SNF1-like kinase 1	6.8	6.8	6.8	pKd	1
Homo sapiens	NUAK family SNF1-like kinase 2	7.6	7.6	7.6	pKd	1
Homo sapiens	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha	5	5	5	pKd	1
Homo sapiens	Phosphatidylinositol-5-phosphate 4-kinase type-2 beta	5.9	5.9	5.9	pKd	1
Homo sapiens	PITSLRE serine/threonine-protein kinase CDC2L1	6.8	6.8	6.8	pKd	1
Homo sapiens	PITSLRE serine/threonine-protein kinase CDC2L2	7	7	7	pKd	1
Homo sapiens	Platelet-derived growth factor receptor alpha	5.4	5.4	5.4	pKd	1
Homo sapiens	Platelet-derived growth factor receptor beta	6	6	6	pKd	1
Homo sapiens	Protein kinase C delta	5.4	5.4	5.4	pKd	1
Homo sapiens	Protein kinase C mu	5.1	5.1	5.1	pKd	1
Homo sapiens	Protein kinase C nu	5.4	5.4	5.4	pKd	1
Homo sapiens	Protein kinase C nu	5.7	5.7	5.7	pKi	1
Homo sapiens	Protein kinase C theta	5.4	5.4	5.4	pKd	1
Homo sapiens	Protein kinase N2	5.7	5.7	5.7	pKd	1
Homo sapiens	Proto-oncogene tyrosine-protein kinase MER	5.6	5.6	5.6	pKd	1
Homo sapiens	Proto-oncogene tyrosine-protein kinase ROS	6.3	6.3	6.3	pKi	1
Homo sapiens	Receptor-interacting serine/threonine-protein kinase 1	5.8	5.8	5.8	pKd	1
Homo sapiens	Rho-associated protein kinase 1	6.9	6.9	6.9	pKi	1
Homo sapiens	Rho-associated protein kinase 2	7.2	7.2	7.2	pKi	1
Homo sapiens	Ribosomal protein S6 kinase alpha 1	5.4	5.4	5.4	pKd	2
Homo sapiens	Ribosomal protein S6 kinase alpha 2	6.4	6.4	6.4	pKd	2
Homo sapiens	Ribosomal protein S6 kinase alpha 3	6	6	6	pKi	2
Homo sapiens	Ribosomal protein S6 kinase alpha 4	5.5	5.5	5.5	pKd	2
Homo sapiens	Serine/threonine-protein kinase 10	7	7	7	pKd	1
Homo sapiens	Serine/threonine-protein kinase 16	6.9	6.9	6.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase 17A	5.3	5.3	5.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase 2	7.3	7.3	7.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase 24	6.8	6.8	6.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase 25	6.4	6.4	6.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase Aurora-A	8	8	8	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Aurora-A	7.2	6.6	7.5	pKd	6
Homo sapiens	Serine/threonine-protein kinase Aurora-A	7.3	7.3	7.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase Aurora-B	8.4	8.4	8.4	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Aurora-B	6.8	6.8	6.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase Aurora-B	7.4	7.4	7.4	pKi	1
Homo sapiens	Serine/threonine-protein kinase Aurora-C	7.1	7.1	7.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase c-TAK1	6.2	6.2	6.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase c-TAK1	6.1	6.1	6.1	pKi	1
Homo sapiens	Serine/threonine-protein kinase DCLK1	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase DCLK2	5.4	5.4	5.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase DCLK3	5.2	5.2	5.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase GAK	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase MARK1	6.2	6.2	6.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase MST1	6.9	6.9	6.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase MST2	7.2	7.2	7.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase MST2	6.7	6.7	6.7	pKi	1
Homo sapiens	Serine/threonine-protein kinase MST4	6.7	6.7	6.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase PAK 3	5.7	5.7	5.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase PAK 4	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase PAK 4	5.9	5.9	5.9	pKi	1
Homo sapiens	Serine/threonine-protein kinase PAK6	5.9	5.9	5.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase PAK7	6.1	6.1	6.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-1	7.6	7.6	7.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-2	6.5	6.5	6.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-3	5.7	5.7	5.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase PFTAIRE-1	5.4	5.4	5.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK1	5.3	5.3	5.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK3	5.2	5.2	5.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK4	6.9	6.9	6.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase receptor R3	5.5	5.5	5.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIO1	6	6	6	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIO3	5.9	5.9	5.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK1	5.7	5.7	5.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK2	5.8	5.8	5.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK2	6.6	6.6	6.6	pKi	1
Homo sapiens	Serine/threonine-protein kinase SRPK1	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO1	7.6	7.6	7.6	pKi	1
Homo sapiens	Serine/threonine-protein kinase TNNI3K	5.9	5.9	5.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase tousled-like 1	6	6	6	pKd	1
Homo sapiens	Serine/threonine-protein kinase tousled-like 2	6.1	6.1	6.1	pKd	1
Homo sapiens	Stem cell growth factor receptor	5.8	5.6	6.2	pKd	6
Homo sapiens	Stem cell growth factor receptor	7.1	7.1	7.1	pKi	1
Homo sapiens	Tyrosine-protein kinase ABL	5.9	5.7	7.2	pKd	7
Homo sapiens	Tyrosine-protein kinase ABL	6.4	6.4	6.4	pKi	1
Homo sapiens	Tyrosine-protein kinase BMX	5.3	5.3	5.3	pKd	1
Homo sapiens	Tyrosine-protein kinase FGR	5.7	5.7	5.7	pKd	1
Homo sapiens	Tyrosine-protein kinase JAK1	7.7	7.7	7.7	pKd	6
Homo sapiens	Tyrosine-protein kinase JAK2	6.7	6.1	7.5	pKd	10
Homo sapiens	Tyrosine-protein kinase JAK2	7	7	7	pKi	2
Homo sapiens	Tyrosine-protein kinase JAK3	6.8	6.8	6.8	pKd	4
Homo sapiens	Tyrosine-protein kinase JAK3	6.7	6.7	6.7	pKi	2
Homo sapiens	Tyrosine-protein kinase LCK	5.6	5.6	5.6	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor FLT3	6.1	5.9	6.2	pKd	5
Homo sapiens	Tyrosine-protein kinase receptor RET	5.4	5.4	6	pKd	2
Homo sapiens	Tyrosine-protein kinase receptor RET	6.2	6.2	6.2	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor Tie-1	6.6	6.6	6.6	pKd	1
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	6.1	6.1	6.1	pKi	1
Homo sapiens	Tyrosine-protein kinase receptor UFO	5.7	5.7	5.7	pKd	1
Homo sapiens	Tyrosine-protein kinase SYK	5.9	5.9	5.9	pKd	1
Homo sapiens	Tyrosine-protein kinase TEC	6	6	6	pKd	1
Homo sapiens	Tyrosine-protein kinase TIE-2	6	6	6	pKd	1
Homo sapiens	Tyrosine-protein kinase TYK2	7.5	7.5	7.5	pKd	4
Homo sapiens	Vascular endothelial growth factor receptor 1	5.7	5.7	5.7	pKd	1
Homo sapiens	Vascular endothelial growth factor receptor 1	6	6	6	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 2	6.9	6.9	6.9	pIC50	1
Homo sapiens	Vascular endothelial growth factor receptor 2	5.4	5.4	5.4	pKd	1
Homo sapiens	Vascular endothelial growth factor receptor 2	6.6	6.6	6.6	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 3	6	6	6	pKd	1

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 R
137

2 P
138

3 L
139

4 G
140

5 K
141

6 G
142

7 K
143

8 F
144

9 G
145

10 N
146

11 V
147

12 Y
148

13 L
149

14 L
159

15 A
160

16 L
161

17 K
162

18 V
163

19 L
164

20 Q
177

•

αC

b.l

21 L
178

22 R
179

23 R
180

24 E
181

25 V
182

26 E
183

27 I
184

28 Q
185

29 S
186

30 H
187

31 L
188

32 R
189

33 P
191

34 N
192

35 I
193

36 L
194

37 R
195

38 L
196

39 Y
197

40 G
198

hinge

linker

αD

αE

41 Y
199

42 Y
207

43 L
208

44 I
209

45 L
210

46 E
211

47 Y
212

48 A
213

49 P
214

50 L
215

51 G
216

52 T
217

53 V
218

54 Y
219

55 R
220

56 E
221

57 L
222

58 Q
223

59 K
224

60 Y
246

•

••

•••

•

αE

c.l

VII

VIII

61 C
247

62 H
248

63 S
249

64 K
250

65 R
251

66 V
252

67 I
253

68 H
254

69 R
255

70 D
256

71 I
257

72 K
258

73 P
259

74 E
260

75 N
261

76 L
262

77 L
263

78 L
264

79 I
272

80 A
273

•

DFG

a.l

81 D
274

82 F
275

83 G
276

84 W
277

85 S
278

Interaction pattern search

Search KLIFS for kinase-ligand complexes with similar interaction patterns: