PDB-code
Browse kinase entries (page 153 of 282)
First 149 150 151 PreviousLast157 156 155 Next| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | File |
|---|---|---|---|---|---|---|---|---|---|---|
 | JAK2 | JakA | TK | 5wev | A | B | n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | Human | Show |  |
| JAK2 | JakA | TK | 6aaj | A | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | Show | | |
| JAK2 | JakA | TK | 6aaj | B | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | Show | | |
| JAK2 | JakA | TK | 6bbv | A | n-{cis-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | Human | Show | | |
| JAK2 | JakA | TK | 6drw | A | A | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | Show | |
| JAK2 | JakA | TK | 6drw | A | B | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | Show | |
| JAK2 | JakA | TK | 6tpd | A | 3-methyl-4-phenyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one | Human | Show | | |
| JAK2 | JakA | TK | 6vgl | A | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | | |
| JAK2 | JakA | TK | 6vgl | B | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | | |
| JAK2 | JakA | TK | 6vgl | C | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | | |
| JAK2 | JakA | TK | 6vgl | D | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | | |
| JAK2 | JakA | TK | 6vn8 | A | baricitinib | Human | Show | | |
| JAK2 | JakA | TK | 6vn8 | B | baricitinib | Human | Show | | |
| JAK2 | JakA | TK | 6vnb | A | (3s)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | | |
| JAK2 | JakA | TK | 6vnc | A | (3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | | |
| JAK2 | JakA | TK | 6vnc | B | (3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | | |
| JAK2 | JakA | TK | 6vne | A | n-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide | Human | Show | | |
| JAK2 | JakA | TK | 6vne | B | n-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide | Human | Show | | |
| JAK2 | JakA | TK | 6vnf | A | A | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | Show | |
| JAK2 | JakA | TK | 6vnf | A | B | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | Show | |
| JAK2 | JakA | TK | 6vnf | B | A | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | Show | |
| JAK2 | JakA | TK | 6vnf | B | B | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | Show | |
| JAK2 | JakA | TK | 6vng | A | n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide | Human | Show | | |
| JAK2 | JakA | TK | 6vng | B | n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide | Human | Show | | |
| JAK2 | JakA | TK | 6vnh | A | n-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide | Human | Show | | |
| JAK2 | JakA | TK | 6vnh | B | n-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide | Human | Show | | |
| JAK2 | JakA | TK | 6vni | A | 2-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-1lambda~6~,2-thiazolidine-1,1-dione | Human | Show | | |
| JAK2 | JakA | TK | 6vnj | A | A | 3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | |
| JAK2 | JakA | TK | 6vnj | B | A | 3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | |
| JAK2 | JakA | TK | 6vnk | A | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | | |
| JAK2 | JakA | TK | 6vnk | B | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | | |
| JAK2 | JakA | TK | 6vnk | C | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | | |
| JAK2 | JakA | TK | 6vnk | D | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | | |
| JAK2 | JakA | TK | 6vnl | A | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | Show | | |
| JAK2 | JakA | TK | 6vnl | B | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | Show | | |
| JAK2 | JakA | TK | 6vnl | C | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | Show | | |
| JAK2 | JakA | TK | 6vnl | D | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | Show | | |
| JAK2 | JakA | TK | 6vnm | A | 4-[1-(but-3-en-1-yl)-1h-pyrazol-4-yl]-n-[4-(piperidin-4-yl)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-2-amine | Human | Show | | |
| JAK2 | JakA | TK | 6vnm | B | 4-[1-(but-3-en-1-yl)-1h-pyrazol-4-yl]-n-[4-(piperidin-4-yl)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-2-amine | Human | Show | | |
| JAK2 | JakA | TK | 6vs3 | A | (3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | | |
| JAK2 | JakA | TK | 6vs3 | B | (3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | | |
| JAK2 | JakA | TK | 6vsn | A | (3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | | |
| JAK2 | JakA | TK | 6vsn | B | (3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | | |
| JAK2 | JakA | TK | 6vsn | C | (3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | | |
| JAK2 | JakA | TK | 6vsn | D | (3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | | |
| JAK2 | JakA | TK | 6wtn | A | A | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | |
| JAK2 | JakA | TK | 6wtn | A | B | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | Show | |
| JAK2 | JakA | TK | 6wto | A | A | baricitinib | Human | Show | |
| JAK2 | JakA | TK | 6wto | A | B | baricitinib | Human | Show | |
| JAK2 | JakA | TK | 6wtp | A | A | tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl]-1h-pyrazol-4-yl}-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoate | Human | Show | |
