Search results (56 entries covering 32 PDB structures)

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#	Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	File
	AKT1	Akt	AGC	8uw7	A	A	4-{2-[({4-[(2p)-2-(2-aminopyridin-3-yl)-5-phenyl-3h-imidazo[4,5-b]pyridin-3-yl]phenyl}methyl)amino]ethyl}-2-hydroxybenzaldehyde	Human	Show
	AKT1	Akt	AGC	8uvy	A	A	4-{2-[({4-[(2p)-2-(2-aminopyridin-3-yl)-5-phenyl-3h-imidazo[4,5-b]pyridin-3-yl]phenyl}methyl)amino]ethyl}-2-hydroxybenzaldehyde	Human	Show
	AKT1	Akt	AGC	8uw9	A	A	n-({4-[(2p)-2-(2-aminopyridin-3-yl)-5-phenyl-3h-imidazo[4,5-b]pyridin-3-yl]phenyl}methyl)-2-(2-fluoro-4-formyl-3-hydroxyphenyl)acetamide	Human	Show
	AKT1	Akt	AGC	8uw2	A	A	4-{2-[({4-[(2p)-2-(2-aminopyridin-3-yl)-5-phenyl-3h-imidazo[4,5-b]pyridin-3-yl]phenyl}methyl)amino]ethyl}-2-hydroxybenzaldehyde	Human	Show
	AKT1	Akt	AGC	8uw7	A	B	4-{2-[({4-[(2p)-2-(2-aminopyridin-3-yl)-5-phenyl-3h-imidazo[4,5-b]pyridin-3-yl]phenyl}methyl)amino]ethyl}-2-hydroxybenzaldehyde	Human	Show
	AKT1	Akt	AGC	8uw2	A	B	4-{2-[({4-[(2p)-2-(2-aminopyridin-3-yl)-5-phenyl-3h-imidazo[4,5-b]pyridin-3-yl]phenyl}methyl)amino]ethyl}-2-hydroxybenzaldehyde	Human	Show
	AKT1	Akt	AGC	6buu	B	C	-	Human	Show
	AKT1	Akt	AGC	8uw9	A	B	n-({4-[(2p)-2-(2-aminopyridin-3-yl)-5-phenyl-3h-imidazo[4,5-b]pyridin-3-yl]phenyl}methyl)-2-(2-fluoro-4-formyl-3-hydroxyphenyl)acetamide	Human	Show
	AKT1	Akt	AGC	8uvy	A	B	4-{2-[({4-[(2p)-2-(2-aminopyridin-3-yl)-5-phenyl-3h-imidazo[4,5-b]pyridin-3-yl]phenyl}methyl)amino]ethyl}-2-hydroxybenzaldehyde	Human	Show
	AKT1	Akt	AGC	6hhi	A		~{n}-[1-[[4-(5-oxidanylidene-3-phenyl-6~{h}-1,6-naphthyridin-2-yl)phenyl]methyl]piperidin-4-yl]-3-(propanoylamino)benzamide	Human	Show
	AKT1	Akt	AGC	7apj	A		-	Human	Show
	AKT1	Akt	AGC	6npz	B	B	-	Human	Show
	AKT1	Akt	AGC	7nh4	A	A	~{n}-[3-[1-[[4-[5-(hydroxymethyl)-3-phenyl-pyridin-2-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{h}-benzimidazol-5-yl]propanamide	Human	Show
	AKT1	Akt	AGC	3mv5	A	A	(3r)-1-(5-methyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine	Human	Show
	AKT1	Akt	AGC	4ejn	A		-	Human	Show
	AKT1	Akt	AGC	6buu	B	B	-	Human	Show
	AKT1	Akt	AGC	4gv1	A	A	4-amino-n-[(1s)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	Human	Show
	AKT1	Akt	AGC	3qkk	A		n-(2-ethoxyethyl)-n-{(2s)-2-hydroxy-3-[(2r)-6-hydroxy-4-oxo-3,4-dihydro-1'h-spiro[chromene-2,3'-piperidin]-1'-yl]propyl}-2,6-dimethylbenzenesulfonamide	Human	Show
	AKT1	Akt	AGC	3qkl	A		n-{(2s)-3-[(3s)-8',9'-dihydro-1h,3'h-spiro[piperidine-3,7'-pyrano[3,2-e]indazol]-1-yl]-2-hydroxypropyl}-n-(2-ethoxyethyl)-2,6-dimethylbenzenesulfonamide	Human	Show
	AKT1	Akt	AGC	3o96	A		-	Human	Show
	AKT1	Akt	AGC	3ow4	A		(2r)-3-(1h-indol-3-yl)-1-{4-[(5s)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}-1-oxopropan-2-amine	Human	Show
	AKT1	Akt	AGC	7nh4	A	B	~{n}-[3-[1-[[4-[5-(hydroxymethyl)-3-phenyl-pyridin-2-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{h}-benzimidazol-5-yl]propanamide	Human	Show
	AKT1	Akt	AGC	6ccy	A	B	(5r)-4-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-(pyrrolidin-1-yl)ethyl]-1h-imidazol-2-yl}piperidin-1-yl)-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6h)-one	Human	Show
	AKT1	Akt	AGC	6npz	A	A	-	Human	Show
	AKT1	Akt	AGC	3qkm	A		n-(2-ethoxyethyl)-n-{(2s)-2-hydroxy-3-[(5r)-2-(quinazolin-4-yl)-2,7-diazaspiro[4.5]dec-7-yl]propyl}-2,6-dimethylbenzenesulfonamide	Human	Show
	AKT1	Akt	AGC	3cqw	A	A	5-(5-chloro-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine	Human	Show
	AKT1	Akt	AGC	6buu	A	C	-	Human	Show
	AKT1	Akt	AGC	3cqu	A	A	n-[2-(5-methyl-4h-1,2,4-triazol-3-yl)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	AKT1	Akt	AGC	6hhh	A		~{n}-[4-[4-[[4-(5-oxidanylidene-3-phenyl-6~{h}-1,6-naphthyridin-2-yl)phenyl]methyl]piperazin-1-yl]phenyl]propanamide	Human	Show
	AKT1	Akt	AGC	6s9x	A		~{n}-[3-[1-[[4-[5-[(4-hydroxyphenyl)methyl]-6-oxidanylidene-2-phenyl-1~{h}-pyrazin-3-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{h}-benzimidazol-5-yl]propanamide	Human	Show
	AKT1	Akt	AGC	5kcv	A		3-[3-[4-(1-azanylcyclobutyl)phenyl]-5-phenyl-imidazo[4,5-b]pyridin-2-yl]pyridin-2-amine	Human	Show
	AKT1	Akt	AGC	4gv1	A	B	4-amino-n-[(1s)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	Human	Show
	AKT1	Akt	AGC	6npz	A	B	-	Human	Show
	AKT1	Akt	AGC	3ocb	B		(2s)-2-(4-chlorobenzyl)-3-oxo-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]propan-1-amine	Human	Show
	AKT1	Akt	AGC	3ocb	A		(2s)-2-(4-chlorobenzyl)-3-oxo-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]propan-1-amine	Human	Show
	AKT1	Akt	AGC	6buu	A	B	-	Human	Show
	AKT1	Akt	AGC	6hhf	A		borussertib	Human	Show
	AKT1	Akt	AGC	7nh5	A	A	~{n}-methyl-6-[4-[[4-[2-oxidanylidene-6-(propanoylamino)-3~{h}-benzimidazol-1-yl]piperidin-1-yl]methyl]phenyl]-5-phenyl-pyridine-3-carboxamide	Human	Show
	AKT1	Akt	AGC	6buu	B	A	-	Human	Show
	AKT1	Akt	AGC	6buu	A	A	-	Human	Show
	AKT1	Akt	AGC	6s9w	A	A	~{n}-[3-[1-[[4-(5-methyl-6-oxidanylidene-3-phenyl-1~{h}-pyrazin-2-yl)phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{h}-benzimidazol-5-yl]propanamide	Human	Show
	AKT1	Akt	AGC	3cqw	A	B	5-(5-chloro-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine	Human	Show
	AKT1	Akt	AGC	6ccy	A	A	(5r)-4-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-(pyrrolidin-1-yl)ethyl]-1h-imidazol-2-yl}piperidin-1-yl)-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6h)-one	Human	Show
	AKT1	Akt	AGC	4ekk	B		phosphoaminophosphonic acid-adenylate ester	Human	Show
	AKT1	Akt	AGC	6hhg	A		~{n}-[2-chloranyl-5-[[1-[[4-(5-oxidanylidene-3-phenyl-6~{h}-1,6-naphthyridin-2-yl)phenyl]methyl]piperidin-4-yl]carbamoylamino]phenyl]propanamide	Human	Show
	AKT1	Akt	AGC	6s9w	A	B	~{n}-[3-[1-[[4-(5-methyl-6-oxidanylidene-3-phenyl-1~{h}-pyrazin-2-yl)phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{h}-benzimidazol-5-yl]propanamide	Human	Show
	AKT1	Akt	AGC	4ekl	A		(2s)-2-(4-chlorophenyl)-1-{4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl}-3-(propan-2-ylamino)propan-1-one	Human	Show
	AKT1	Akt	AGC	7nh5	A	B	~{n}-methyl-6-[4-[[4-[2-oxidanylidene-6-(propanoylamino)-3~{h}-benzimidazol-1-yl]piperidin-1-yl]methyl]phenyl]-5-phenyl-pyridine-3-carboxamide	Human	Show
	AKT1	Akt	AGC	3mv5	A	B	(3r)-1-(5-methyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine	Human	Show
	AKT1	Akt	AGC	3mvh	A	B	n-{[(3s)-3-amino-1-(5-ethyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl]methyl}-2,4-difluorobenzamide	Human	Show
	AKT1	Akt	AGC	4ekk	A		phosphoaminophosphonic acid-adenylate ester	Human	Show
	AKT1	Akt	AGC	3cqu	A	B	n-[2-(5-methyl-4h-1,2,4-triazol-3-yl)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	Show
	AKT1	Akt	AGC	6hhj	A		~{n}-[1-methyl-2-oxidanylidene-3-[1-[[4-(5-oxidanylidene-3-phenyl-6~{h}-1,6-naphthyridin-2-yl)phenyl]methyl]piperidin-4-yl]benzimidazol-5-yl]propanamide	Human	Show
	AKT1	Akt	AGC	3ow4	B		(2r)-3-(1h-indol-3-yl)-1-{4-[(5s)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}-1-oxopropan-2-amine	Human	Show
	AKT1	Akt	AGC	6npz	B	A	-	Human	Show
	AKT1	Akt	AGC	3mvh	A	A	n-{[(3s)-3-amino-1-(5-ethyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl]methyl}-2,4-difluorobenzamide	Human	Show

Division of Medicinal Chemistry - Vrije Universiteit Amsterdam